anti-Src Kinase Associated phosphoprotein 1 (SKAP1) Antibodies

SKAP1 encodes a T cell adaptor protein, a class of intracellular molecules with modular domains capable of recruiting additional proteins but that exhibit no intrinsic enzymatic activity. Additionally we are shipping SKAP1 Proteins (12) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SKAP1 78473 Q3UUV5
SKAP1 8631 Q86WV1
SKAP1 286975 Q4V7G1
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Top anti-SKAP1 Antibodies at antibodies-online.com

Showing 10 out of 81 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated IF, WB Western blot analysis of SKAP55 on rat thymus lysate. Lane 1: 1:1000, lane 2: 1:2000, lane 3: 1:4000 dilution of SKAP55. HeLa 50 μg Log in to see 6 to 8 Days
$154.07
Details
Human Mouse Un-conjugated WB SCAP1 monoclonal antibody (M02), clone 1C11 Western Blot analysis of SCAP1 expression in Jurkat. Detection limit for recombinant GST tagged SCAP1 is approximately 0.3 ng/mL as a capture antibody. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Mouse Un-conjugated IHC (p), ELISA, WB Immunoperoxidase of monoclonal antibody to SCAP1 on formalin-fixed paraffin-embedded human tonsil (antibody concentration 3 µg/mL). 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of SKAP55 expression in PANC whole cell lysates (lane 1) and JURKAT whole cell lysates (lane 2). SKAP55 at 60KD was detected using rabbit anti- SKAP55 Antigen Affinity purified polyclonal antibody at0.5 μg/mL. The blot was developed using chemiluminescence (ECL) method SKAP55 was detected in paraffin-embedded sections of rat spleen tissues using rabbit anti- SKAP55 Antigen Affinity purified polyclonal antibody at 1 μg/mL. The immunohistochemical section was developed using SABC method 100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p) Immunocytochemistry/Immunofluorescence: SKAP55 Antibody [NBP1-87836] - Staining of human cell line U-2 OS shows positivity in nucleus & cytoplasm. Immunohistochemistry-Paraffin: SKAP55 Antibody [NBP1-87836] Staining of human lymph node shows moderate cytoplasmic positivity. 0.1 mL Log in to see 10 to 13 Days
$439.69
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 7 to 9 Days
$551.83
Details
Human Rabbit Un-conjugated WB SKAP1 Antibody (C-term) western blot analysis in MDA-MB453 cell line lysates (35ug/lane).This demonstrates the SKAP1 antibody detected the SKAP1 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC (p), WB IHC-P Image SKAP55 antibody detects SKAP1 protein at cytoplasm on human colon carcinoma by immunohistochemical analysis. Sample: Paraffin-embedded colon carcinoma. SKAP55 antibody , dilution: 1:500. WB Image Sample (30 ug of whole cell lysate) A: NT2D1 10% SDS PAGE SKAP55 antibody antibody diluted at 1:1000 100 μL Log in to see 1 to 2 Days
$358.60
Details
Human Rabbit Un-conjugated IHC, IHC (p), WB Western Blot: SKAP55 Antibody [NBP1-32479] - Sample (30 ug of whole cell lysate) A: NT2D1 10% SDS PAGE SKAP55 antibody, antibody diluted at 1:1000. 100 μL Log in to see 7 to 9 Days
$447.56
Details

SKAP1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Mouse (Murine)


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Top referenced anti-SKAP1 Antibodies

  1. Human Monoclonal SKAP1 Primary Antibody for IF, WB - ABIN968435 : Liu, Kang, Raab, da Silva, Kraeft, Rudd: FYB (FYN binding protein) serves as a binding partner for lymphoid protein and FYN kinase substrate SKAP55 and a SKAP55-related protein in T cells. in Proceedings of the National Academy of Sciences of the United States of America 1998 (PubMed)
    Show all 5 Pubmed References

  2. Human Polyclonal SKAP1 Primary Antibody for ICC, IF - ABIN4353952 : van Doorn, van Kester, Dijkman, Vermeer, Mulder, Szuhai, Knijnenburg, Boer, Willemze, Tensen: Oncogenomic analysis of mycosis fungoides reveals major differences with Sezary syndrome. in Blood 2009 (PubMed)

More Antibodies against SKAP1 Interaction Partners

Mouse (Murine) Src Kinase Associated phosphoprotein 1 (SKAP1) interaction partners

  1. SKAP1 can affect the function of talin in T-cells needed for optimal T-cell/dendritic cell conjugation

  2. this study shows that Skap1-deficient (skap1-/-) mice are highly resistant to the induction of collagen-induced arthritis

  3. In this study, the authors identified that the ADAP (show APP Antibodies)-SKAP55 signaling module reduced CD8 (show CD8A Antibodies)(+) cytotoxic T lymphocyte cytotoxicity and enhanced PD-1 (show PDCD1 Antibodies) expression in a Fyn (show FYN Antibodies)-, Ca(2 (show CA2 Antibodies)+)-, and NFATc1 (show NFATC1 Antibodies)-dependent manner.

  4. Data suggest that the presence or absence of associated SKAP55 defines functionally distinct pools of ADAP (show APP Antibodies).

  5. HPK1 (show MAP4K1 Antibodies) associates with SKAP1 to negatively regulate Rap1 (show TERF2IP Antibodies)-mediated B-lymphocyte (show AKAP17A Antibodies) adhesion.

  6. SKAP1 is dispensable for both CXCL12 (show CXCL12 Antibodies) and CCL21 (show CCL21 Antibodies) induced T-cell migration.

  7. findings define a T cell receptor "inside-out" pathway via N-SKAP1-C-RapL (show RASSF5 Antibodies) that regulates T cell adhesion, motility, and arrest times with dendritic cells in lymph nodes.

  8. Results identify a clear effector role for SKAP-55 in LFA-1 adhesion in peripheral T cells and demonstrate that dependency on SKAP-55 and ADAP differs among T cells and differs with the strength of the TCR signal.

Human Src Kinase Associated phosphoprotein 1 (SKAP1) interaction partners

  1. K152 and D120 within the PH domain of SKAP55 regulate plasma membrane targeting and T cell receptor-mediated activation of LFA-1 (show ITGAL Antibodies).

  2. SKAP55 dimers stabilize SLP-76 (show LCP2 Antibodies) microclusters, couple SLP-76 (show LCP2 Antibodies) to the force-generating systems responsible for microcluster movement, and enable adhesion via the TCR by mechanisms independent of RIAM (show APBB1IP Antibodies), talin, and beta1 integrins.

  3. single-nucleotide polymorphisms in ARRDC3, FLT1 (show FLT1 Antibodies), and SKAP1 were significant predictors for survival androgen-deprivation therapy in prostate cancer patients.

  4. N-terminal myr-tagged SKAP1 for membrane binding facilitated constitutive RapL (show RASSF5 Antibodies) membrane and Rap1 (show RABGEF1 Antibodies) binding and effectively substituted for PI3K (show PIK3CA Antibodies) and TCR ligation in the activation of LFA-1 (show ITGAL Antibodies) in T cells.

  5. Single nucleotide polymorphism in SKAP1 is associated with ovarian cancer.

  6. findings define a T cell receptor "inside-out" pathway via N-SKAP1-C-RapL (show RASSF5 Antibodies) that regulates T cell adhesion, motility, and arrest times with dendritic cells in lymph nodes.

  7. SKAP55 coupled with CD45 (show PTPRC Antibodies) positively regulates T-cell receptor-mediated gene transcription.

  8. observation that adapter protein (show TOLLIP Antibodies) SKAP55 formed homodimers through its SH3 domain (show ITSN1 Antibodies) and SK region

  9. SKAP-55 regulates integrin-mediated adhesion and conjugate formation between T cells and antigen-presenting cells

  10. stimuli that signal for the stabilization of SKAP55 may play an important role in T cell adhesion and conjugate formation

SKAP1 Antigen Profile

Protein Summary

This gene encodes a T cell adaptor protein, a class of intracellular molecules with modular domains capable of recruiting additional proteins but that exhibit no intrinsic enzymatic activity. The encoded protein contains a unique N-terminal region followed by a PH domain and C-terminal SH3 domain. Along with the adhesion and degranulation-promoting adaptor protein, the encoded protein plays a critical role in inside-out signaling by coupling T-cell antigen receptor stimulation to the activation of integrins.

Gene names and symbols associated with SKAP1

  • src family associated phosphoprotein 1 (Skap1) antibody
  • src kinase associated phosphoprotein 1 (SKAP1) antibody
  • src kinase associated phosphoprotein 1 (Skap1) antibody
  • 1700091G21Rik antibody
  • SCAP1 antibody
  • Skap-55 antibody
  • Skap55 antibody

Protein level used designations for SKAP1

ortholog of human src family associated phosphoprotein 1 SCAP1 , src family-associated phosphoprotein 1 , src kinase-associated phosphoprotein 1 , SKAP-55 , pp55 , src family associated phosphoprotein 1 , src kinase-associated phosphoprotein of 55 kDa , SKAP55 adapter protein , SKAP55 adaptor protein

GENE ID SPECIES
78473 Mus musculus
8631 Homo sapiens
286975 Rattus norvegicus
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