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STC2 encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. Additionally we are shipping Stanniocalcin 2 Antibodies (106) and Stanniocalcin 2 Kits (9) and many more products for this protein.
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Recombinant human and fish STC2 proteins were generated and found to be N-glycosylated homodimers. STC2 is a functional homodimeric glycoprotein, and thecal cell-derived STC2 could play a paracrine role during follicular development. (Stanniocalcin-2)
Up-regulation of CDK2 and CDK4 and down-regulation of cell cycle inhibitors p16 and p21 were observed after the delivery of STC2. Furthermore, STC2 transduction activated pAKT and pERK 1/2 signal pathways.
The results showed that the expression of HMGA2 and STC2 was positively correlated. Furthermore, STC2 expression was significantly associated with tumor grade and histotype.
This study utilized ER+ IBC to identify a metagene including ABAT (show ABAT Proteins) and STC2 as predictive biomarkers for endocrine therapy resistance.
STC2 may inhibit epithelial-mesenchymal transition at least partially through the PKC (show PRRT2 Proteins)/Claudin-1 (show CLDN7 Proteins)-mediated signaling in human breast cancer cells.
STC2 has a role in promoting cell proliferation and cisplatin resistance in cervical cancer
The aim of this study was to evaluate the clinical value of measuring expression levels of STC2 in colorectal cancer (CRC (show CALR Proteins)) patients.
Stanniocalcin 2 may contribute to tumor development and radioresistance in cervical cancer.
These findings suggest that STC2 can be a potential lung cancer biomarker and plays a positive role in lung cancer metastasis and progression.
Circulating STC1 (show STC1 Proteins) and STC2 mRNA are potentially useful blood markers for LSCC
High STC2 expression is associated with glioma.
Stanniocalcin-2 inhibits proteolytic release of IGF and its ability to cause growth retardation upon transgenic overexpression in mice depends on its proteinase inhibitory function.
The Stc2 promoter contains multiple putative xenobiotic response elements.
These results suggest that the up-regulation of STC2 gene expression resulting from abnormal alpha-klotho (show KL Proteins)-Fgf23 (show FGF23 Proteins) signaling may contribute to limitation of ectopic calcification.
These results define a novel molecular function for STC2 as a negative modulator of Store-Operated Calcium Entry and provide the first direct evidence for the regulation of Ca2 (show CA2 Proteins)+ homeostasis by mammalian STC2.
STC2 is linked to PERK signalling in acinar cells and has a role in limiting damage during pancreatic injury.
induced STC2 expression is an essential feature of survival component of the unfolded-protein response
The murine stanniocalcin 2 gene is a negative regulator of postnatal growth.
This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The encoded protein has 10 of its 15 cysteine residues conserved among stanniocalcin family members and is phosphorylated by casein kinase 2 exclusively on its serine residues. Its C-terminus contains a cluster of histidine residues which may interact with metal ions. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Constitutive overexpression of human stanniocalcin 2 in mice resulted in pre- and postnatal growth restriction, reduced bone and skeletal muscle growth, and organomegaly. Expression of this gene is induced by estrogen and altered in some breast cancers.
, STC-related protein
, stanniocalcin-related protein