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Steroid-5-alpha-Reductase, alpha Polypeptide 1 (3-Oxo-5 alpha-Steroid delta 4-Dehydrogenase alpha 1) Proteins (SRD5A1)

Steroid 5-alpha-reductase (EC 1.3.99.5) catalyzes the conversion of testosterone into the more potent androgen, dihydrotestosterone (DHT). Additionally we are shipping SRD5A1 Antibodies (50) and SRD5A1 Kits (18) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SRD5A1 78925 Q68FF9
SRD5A1 6715 P18405
Rat SRD5A1 SRD5A1 24950 P24008
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Top SRD5A1 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details

SRD5A1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,
,

More Proteins for Steroid-5-alpha-Reductase, alpha Polypeptide 1 (3-Oxo-5 alpha-Steroid delta 4-Dehydrogenase alpha 1) (SRD5A1) Interaction Partners

Mouse (Murine) Steroid-5-alpha-Reductase, alpha Polypeptide 1 (3-Oxo-5 alpha-Steroid delta 4-Dehydrogenase alpha 1) (SRD5A1) interaction partners

  1. the Srd5a1 gene modulates ethanol consumption in a sex-dependent manner that is also contingent upon ethanol access condition and concentration

  2. deletion of the Srd5a1 gene significantly decreased ethanol's anxiolytic effect in female mice, and chronic ethanol withdrawal severity was lower in female versus male mice

  3. transcription of srd5a1 in brain is regulated by environmental factor-induced cytosine methylation in the promoter region.

  4. The effects of deficiency or inhibition of S5AR1 on the risk of liver disease and insulin (show INS Proteins) resistance in male rats and mice are reported.

  5. Thus, 5alpha-reductase may be required for the estrous cycle variations in affective behavior and 3alpha,5alpha-THP (show UMOD Proteins) levels of female mice.

  6. results suggest that local steroid 5 alpha-reductase 1 messenger RNA expression in Withdrawal Seizure-Prone mouse brain may not change in parallel with local allopregnanolone content or withdrawal severity

  7. The aim of the present study was to investigate the role of 5alpha-reductase type 1 for bone mass using Srd5a1-/- mice.

  8. This study evaluates 5alpha-R type I and 3alpha-HSD (show DHRS9 Proteins) mRNA expression level in mouse brain by using in situ hybridization.

  9. Data suggests that in male mice after social isolation, expression of Srd5a1 mRNA is specifically down-regulated in glutamatergic pyramidal neurons. In socially isolated mice, this down-regulation may account for the appearance of behavioral disorders.

Human Steroid-5-alpha-Reductase, alpha Polypeptide 1 (3-Oxo-5 alpha-Steroid delta 4-Dehydrogenase alpha 1) (SRD5A1) interaction partners

  1. the genotypic distribution of 22 single nucleotide polymorphisms in SRD5A1 and SRD5A2 (show SRD5A2 Proteins) in a set of Spanish prostate cancer patients, were evaluated.

  2. A total of 2 SNPs in SRD5A1-rs3822430 and rs1691053-were associated with prostate-specific antigen (show KLK3 Proteins) level at diagnosis.

  3. In model cell lines of endometrial cancer, AKR1C2 (show AKR1C2 Proteins) and SRD5A1 have crucial roles in progesterone metabolism.

  4. SRD5A1 rs166050C risk variant was associated with greater prostatic exposure to androsterone

  5. Significantly higher levels of SRD5A1, AKR1C2 (show AKR1C2 Proteins), AKR1C3 (show AKR1C3 Proteins), and HSD17B10 (show HSD17B10 Proteins) mRNA were however found in bone metastases than in non-malignant and/or malignant prostate tissue

  6. SRD5A1 and SRD5A2 (show SRD5A2 Proteins) single nucleotide polymorphisms are significantly associated with the clinical characteristics of benign prostatic hyperplasia and the efficacy of benign prostatic hyperplasia treatment.

  7. Different effects were seen for progesterone, which significantly decreased SRD5A1 protein levels.

  8. Postmenopausal breast cancer risk associated with combined therapy may be modified by genetic variation in SRD5A1

  9. Based on a limited selection of gene variants, no involvement of SRD5A1, SRD5A2 (show SRD5A2 Proteins), ESR1 (show ESR1 Proteins), ESR2 (show ESR2 Proteins) or PGR (show PGR Proteins) in female pattern hair loss is evident.

  10. Ten percent of cases and 44% of controls had the cytosine/cytosine (C/C) genotype for the SRD5A1 SNP, rs501999 indicating that this genotype may protect women against severe premenstrual symptoms.

SRD5A1 Protein Profile

Protein Summary

Steroid 5-alpha-reductase (EC 1.3.99.5) catalyzes the conversion of testosterone into the more potent androgen, dihydrotestosterone (DHT). Also see SRD5A2 (MIM 607306).

Gene names and symbols associated with SRD5A1

  • steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) (SRD5A1)
  • steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) (srd5a1)
  • 3-oxo-5-alpha-steroid 4-dehydrogenase 1 (Bm1_06570)
  • 3-oxo-5-alpha-steroid 4-dehydrogenase 1 (CC1G_14953)
  • steroid 5 alpha-reductase 1 (Srd5a1)
  • steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) (Srd5a1)
  • 0610031P22Rik protein
  • 4930435F02Rik protein
  • S5AR 1 protein
  • Srd5a-1 protein
  • zgc:153768 protein

Protein level used designations for SRD5A1

steroid-5-alpha-reductase 1 , 3-oxo-5-alpha-steroid 4-dehydrogenase 1 , SR type 1 , steroid 5-alpha-reductase 1 , type 1 5alpha-reductase , 3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1 , 5-alpha reductase , steroid 5-alpha-reductase type I , steroid 5 alpha-reductase 1 , prostatic steroid 5-alpha-reductase type I , 3-oxo-5-alpha-steroid 4-dehydrogenase 1-like

GENE ID SPECIES
743740 Pan troglodytes
767715 Danio rerio
6096243 Brugia malayi
9378132 Coprinopsis cinerea okayama7130
78925 Mus musculus
6715 Homo sapiens
24950 Rattus norvegicus
403716 Canis lupus familiaris
614612 Bos taurus
770453 Gallus gallus
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