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Steroidogenic Acute Regulatory Protein Proteins (STAR)

The protein encoded by STAR plays a key role in the acute regulation of steroid hormone synthesis by enhancing the conversion of cholesterol into pregnenolone. Additionally we are shipping STAR Antibodies (50) and STAR Kits (21) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
STAR 20845 P51557
STAR 25557 P97826
STAR 6770 P49675
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Top STAR Proteins at antibodies-online.com

Showing 10 out of 20 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
Yeast Salvelinus alpinus His tag   1 mg Log in to see 56 to 66 Days
$2,091.83
Details
Yeast Chicken His tag   1 mg Log in to see 56 to 66 Days
$2,541.00
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,553.83
Details
Yeast Wild boar His tag   1 mg Log in to see 56 to 66 Days
$2,553.83
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,553.83
Details
Yeast Sheep His tag   1 mg Log in to see 56 to 66 Days
$2,553.83
Details

STAR Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Rat (Rattus)

Human , ,
,

Top referenced STAR Proteins

  1. Human STAR Protein expressed in Escherichia coli (E. coli) - ABIN667607 : Borthwick, Taylor, Bartholomew, Graham: Differential regulation of the STARD1 subfamily of START lipid trafficking proteins in human macrophages. in FEBS letters 2009 (PubMed)
    Show all 2 references for ABIN667607

More Proteins for Steroidogenic Acute Regulatory Protein (STAR) Interaction Partners

Mouse (Murine) Steroidogenic Acute Regulatory Protein (STAR) interaction partners

  1. cAMP, SIK and CRTC mediate StAR expression through activation of individual StAR gene loci.

  2. Bisphenol A induces oxidative stress by altering the expression of iNOS (show NOS2 Proteins), which consequently leads to the down regulation of StAR expression in the testis of male mouse

  3. Results show that HIF1alpha (show HIF1A Proteins) appears to be a positive regulator of basal and stimulated STAR-expression, which under partial hypoxia is capable of increasing the steroidogenic capacity of granulosa cells.

  4. The result showed significant correlation between changes in GLUT 8 (show SLC2A8 Proteins) and glucose levels with changes in StAR level in the testis and circulating testosterone level in the mice from birth to senescence

  5. Deletion of the START domain from Arabidopsis Glabra2, a representative HD-Zip transcription factor, results in a complete loss-of-function phenotype. The mammalian START domain from StAR can functionally replace the HD-Zip-derived START domain.

  6. These discoveries highlight the importance of mitochondrial fusion and ERK (show EPHB2 Proteins) phosphorylation in cholesterol transport by means of directing StAR to the outer mitochondrial membrane.

  7. Data indicate that macrophages exhibited a strong time-dependent induction of mitochondrial StarD1 and plasma membrane ABCA1 (show ABCA1 Proteins), which exports cholesterol.

  8. Data suggest that the regulation of StAR by transcription factors including SF-1 (show SF1 Proteins), GATA-4 (show GATA4 Proteins) and C/EBP-beta (show CEBPB Proteins) maybe critical mechanism involved in low-dose MBP (show MBP Proteins)-stimulated steroidogenesis.

  9. Sodium fluoride inhibited expression of StAR and P450scc (show CYP11A1 Proteins) in mouse Leydig tumor cells, which inhibited progesterone secretion.

  10. HSL (show LIPE Proteins) acts to drive cAMP/PKA-mediated regulation of StAR expression and steroidogenesis in mouse Leydig cells.

Human Steroidogenic Acute Regulatory Protein (STAR) interaction partners

  1. activins A, B and AB down-regulate StAR expression and decrease progesterone production in human granulosa cells, likely via an ALK4 (show ACVR1B Proteins)-mediated SMAD2 (show SMAD2 Proteins)/SMAD4 (show SMAD4 Proteins)-dependent pathway.

  2. Mutagenesis confirmed that Arg(312) and Arg(313) are crucial for this mode of regulation, and novel interactions with the START domain

  3. StAR proteolysis is executed by at least 2 mitochondrial proteases, the matrix LON (show LONP1 Proteins) protease and the inner membrane complexes of the metalloproteases AFG3L2 (show AFG3L2 Proteins) and AFG3L2 (show AFG3L2 Proteins):SPG7/paraplegin (show SPG7 Proteins).

  4. BMP15 (show BMP15 Proteins) down-regulates StAR expression and decreases progesterone production in human granulosa cells, likely via ALK3 (show BMPR1A Proteins)-mediated SMAD1 (show GARS Proteins)/5/8 signaling.

  5. The novel mutation p.Trp147Arg of the steroidogenic acute regulatory protein causes classic lipoid congenital adrenal hyperplasia with adrenal insufficiency and 46,XY disorder of sex development.

  6. Expression of StAR and P45011beta (cytochrome P450 family 11 subfamily B polypeptide 1 (show CYP11B1 Proteins)) is down-regulated in adrenocortical cells and neurons under oxidative stress by ALADIN (show AAAS Proteins) (triple A syndrome protein, human) knockdown.

  7. deficiencies in the steroidogenic acute regulatory protein and the cholesterol side chain cleavage (show CYP11A1 Proteins) enzyme cause neonatal adrenal failure

  8. Mutant FOXL2 (show FOXL2 Proteins) in granulosa cell tumors is able to differentially regulate the expression of many genes, including two well known FOXL2 (show FOXL2 Proteins) targets, StAR and CYP19A (show CYP19A1 Proteins).

  9. Mutations in the CYP11A1 (show CYP11A1 Proteins) gene encoding cholesterol side-chain cleavage (show CYP11A1 Proteins) enzyme cause disordered pregnenolone synthesis, and STAR mutations do not necessarily results in typical congenital lipoid adrenal hyperplasia.

  10. The status of ARO (show CYP19A1 Proteins) and StAR contribute to estrogen synthesis in situ, especially for the regulation of elastic fiber formation, and to testosterone synthesis, which may be associated with hair growth, respectively.

Cow (Bovine) Steroidogenic Acute Regulatory Protein (STAR) interaction partners

  1. Data indicate that Ser738/742-to-glutamate (show GRIN2A Proteins) protein kinase D (show PRKD1 Proteins) mutant increased AngII-induced CREB (show CREB1 Proteins) protein and activating transcription factor 2 (show ATF2 Proteins) phosphorylation, and phospho-CREB (show CREB1 Proteins) binding to the steroidogenic acute regulatory protein promoter.

  2. Data suggest that Escherichia coli infections (here, administration of LPS (show IRF6 Proteins)) provokes luteolysis in diestrus, non-lactating cows and down-regulation of expression of StAR in corpus luteum but has no effect on luteinization in the following cycle.

  3. The binding of SF-1 (show NR5A1 Proteins) to the CYP17 (show CYP17A1 Proteins) and StAR promoter regions increased in theca cells incubated with low levels of luteinizing hormone.

  4. Inhibition of the acetylation of histone H3 (show HIST3H3 Proteins) associated with the StAR promoter region by BMP-4 (show BMP4 Proteins) may be one of the inhibitory molecular mechanisms of progesterone synthesis in granulosa cells.

  5. c-Fos/c-Jun (show JUN Proteins) complex binds to the proximal StAR promoter in glomerulosa cells, thus activating StAR gene expression and acute aldosterone biosynthesis.

Guinea Pig Steroidogenic Acute Regulatory Protein (STAR) interaction partners

  1. The results showed that MMP-2 (show MMP2 Proteins), MMP-9 (show MMP9 Proteins), and StAR were significantly expressed in the granulosa and thecal cells of the ovarian atretic follicles during proestrus, and were strongly expressed in the corpus luteum during metestrus.

Pig (Porcine) Steroidogenic Acute Regulatory Protein (STAR) interaction partners

  1. GATA-4 (show GATA4 Proteins) and C/EBPbeta (show CEBPB Proteins) are both required for FSH (show BRD2 Proteins) +/- IGF-I (show IGF1 Proteins) stimulation of the porcine steroidogenic acute regulatory protein gene promoter in homologous granulosa cell cultures.

  2. EGF (show EGF Proteins) repression of FSH (show BRD2 Proteins)-stimulated StAR transcription in porcine granulosa cells is accompanied by reductions in histone H3 (show HIST3H3 Proteins) acetylation associated with the StAR gene promoter

  3. The altered ratio of GATA4 (show GATA4 Proteins) to GATA6 (show GATA6 Proteins) after ovulation may allow GATA6 (show GATA6 Proteins) to enhance STAR mRNA accumulation.

  4. Under hypoxia reoxygenation or ischemia and reperfusion, StAR and CYP11A1 protein and gene expression was reduced without apparent relation to TSPO changes.

Rainbow Trout (Oncorhynchus mykiss) Steroidogenic Acute Regulatory Protein (STAR) interaction partners

  1. Data suggest enzymes in steroidogenic pathway are induced in interrenal cells during acute/chronic stress: mc2r (melanocortin 2 receptor); StAR (steroidogenic acute regulatory protein); 3beta-hydroxysteroid dehydrogenase; steroid 11beta hydroxylase.

Zebrafish Steroidogenic Acute Regulatory Protein (STAR) interaction partners

  1. Results suggest that gonadotropins play a key role in the regulation of StAR, 17beta-HSD3, and P450aromA in zebrafish.

STAR Protein Profile

Protein Summary

The protein encoded by this gene plays a key role in the acute regulation of steroid hormone synthesis by enhancing the conversion of cholesterol into pregnenolone. This protein permits the cleavage of cholesterol into pregnenolone by mediating the transport of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane. Mutations in this gene are a cause of congenital lipoid adrenal hyperplasia (CLAH), also called lipoid CAH. A pseudogene of this gene is located on chromosome 13.

Gene names and symbols associated with STAR

  • steroidogenic acute regulatory protein (STAR)
  • steroidogenic acute regulatory protein (star)
  • steroidogenic acute regulator (LOC100219165)
  • steroidogenic acute regulatory protein (Star)
  • steroidogenic acute regulatory protein-like (LOC100353723)
  • AV363654 protein
  • D8Ertd419e protein
  • LOC100219165 protein
  • star protein
  • StARD1 protein

Protein level used designations for STAR

steroidogenic acute regulator , steroidogenic acute regulatory protein , mitochondrial steroidogenic acute regulatory protein , steroidogenic acute regulatory protein, mitochondrial , START domain-containing protein 1 , luteinizing hormone-induced protein , stARD1 , START domain containing 1 , StAR-related lipid transfer (START) domain containing 1 , cholesterol trafficker , mitochondrial steroid acute regulatory protein , steroid acute regulatory protein , lipid transporter

GENE ID SPECIES
746738 Pan troglodytes
751772 Taeniopygia guttata
100125473 Oryzias latipes
100219165 Taeniopygia guttata
100528320 Ictalurus punctatus
100616071 Felis catus
20845 Mus musculus
25557 Rattus norvegicus
6770 Homo sapiens
475588 Canis lupus familiaris
281507 Bos taurus
395421 Gallus gallus
100009707 Equus caballus
443122 Ovis aries
100732626 Cavia porcellus
396597 Sus scrofa
100381120 Xenopus laevis
100135806 Oncorhynchus mykiss
63999 Danio rerio
101844174 Mesocricetus auratus
100353723 Oryctolagus cuniculus
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