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anti-Streptococcal Pyrogenic Exotoxin B (SPEB) Antibodies

Important streptococcal virulence factor which cleaves human fibronectin and degrades vitronectin.

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Streptococcal Pyrogenic Exotoxin B (SPEB) Antigen Profile

Protein Summary

Important streptococcal virulence factor which cleaves human fibronectin and degrades vitronectin. Also cleaves human IL1B precursor to form biologically active IL1B. Can induce apoptosis in human monocytes and epithelial cells in vitro, and reduces phagocytic activity in monocytic cells. Thus, may play a role in bacterial colonization, invasion, and inhibition of wound healing.

Gene names and symbols associated with SPEB

  • streptococcal pyrogenic exotoxin B (speB) antibody

Protein level used designations for SPEB

streptococcal pyrogenic exotoxin B

GENE ID SPECIES
3571136 Streptococcus pyogenes MGAS5005
3574450 Streptococcus pyogenes MGAS6180
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