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Stress-Induced-phosphoprotein 1 Proteins (STIP1)

STIP1 is an adaptor protein that coordinates the functions of HSP70 (see HSPA1A\; MIM 140550) and HSP90 (see HSP90AA1\; MIM 140571) in protein folding. Additionally we are shipping Stress-Induced-phosphoprotein 1 Antibodies (63) and Stress-Induced-phosphoprotein 1 Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Mouse STIP1 STIP1 20867 Q60864
STIP1 192277 O35814
STIP1 10963 P31948
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Top Stress-Induced-phosphoprotein 1 Proteins at

Showing 4 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
HOST_Escherichia coli (E. coli) Human GST tag,His tag   100 μg Log in to see 11 to 13 Days
Human Un-conjugated   2 μg Log in to see 6 Days

STIP1 Proteins by Origin and Source

Origin Expressed in Conjugate
Rat (Rattus)


Top referenced Stress-Induced-phosphoprotein 1 Proteins

  1. Human STIP1 Protein expressed in Escherichia coli (E. coli) - ABIN668048 : van der Spuy, Cheetham, Dirr, Blatch: The cochaperone murine stress-inducible protein 1: overexpression, purification, and characterization. in Protein expression and purification 2001 (PubMed)
    Show all 2 references for ABIN668048

More Proteins for Stress-Induced-phosphoprotein 1 (STIP1) Interaction Partners

Mouse (Murine) Stress-Induced-phosphoprotein 1 (STIP1) interaction partners

  1. Reduced STIP1 levels can contribute to phenotypes related to hyperactivity and attention deficits.

  2. We correlate the expression of STI1 and glioma progression, and suggest that STI1 expression in microglia/macrophages and infiltrating lymphocytes is modulated by the brain tumor microenvironment.

  3. Knockdown of PIAS1 (show PIAS1 Proteins) in astrocytes impairs the accumulation of nuclear STI1 in response to irradiation. Moreover, a PIAS1 (show PIAS1 Proteins) mutant lacking the STI1 binding site is unable to increase STI1 nuclear retention.

  4. stress-inducible protein-1 has a role in recruitment of bone marrow derived cells into the ischemic brains

  5. Our findings reveal a previously unrecognized role of the PrP(C (show PRNP Proteins)) ligand STI1 in protecting neurons in Alzheimer disease and suggest a novel pathway that may help to offset AbetaO-induced toxicity.

  6. Stress-inducible phosphoprotein 1 has unique cochaperone activity during development and regulates cellular response to ischemia via the prion protein (show PRNP Proteins).

  7. STI1 and laminin-gamma1 promote robust axonogenesis in wild-type dorsal root ganglia neurons; STI1 promotes extracellular calcium influx.

  8. Neuroprotection and neuritogenesis mediated by PrP(C (show PRNP Proteins))-STI1 engagement are dependent upon the increased protein synthesis mediated by PI3K-mTOR (show FRAP1 Proteins) signaling.

  9. evaluated the temporal expression pattern of STI1 and Vn and their colocalization with their ligand PrPC (show PRNP Proteins), demonstrated that PrPC (show PRNP Proteins), STI1, and Vn are coexpressed in most of the embryonic tissues evaluated.

  10. Stress-inducible protein 1 is a cell surface ligand for cellular prion (show PRNP Proteins) that triggers neuroprotection. The interaction sites were mapped to amino acids 113-128 from PrP(c (show PRNP Proteins)) and 230-245 from STI1. Both proteins are associated in vivo.

Human Stress-Induced-phosphoprotein 1 (STIP1) interaction partners

  1. Data confirmed the significant up-regulation of STIP1 in tumorous cholangiocytes relative to normal hepatocytes and non-tumorous cells and show prooved it as a reliable diagnostic biomarker when using immunohistochemistry.

  2. STIP1 and moesin (show MSN Proteins) may be novel and differential sero-diagnostic markers for psoriasis vulgaris and psoriatic arthritis

  3. Stip1 has a role in the male reproductive system and is expressed during the stress response

  4. Increased STIP1 expression is associated with poor survival outcome in epithelial ovarian cancer (EOC), and STIP1 may represent a useful therapeutic target in EOC patients.

  5. our findings provide evidences that positive expression of STIP1 in papillary thyroid carcinoma may be important in the acquisition of an aggressive phenotype

  6. These results indicate that HOP is a unique co-chaperone that undergoes an ATP-dependent conformational change.

  7. STIP1 histoscores may be useful in detecting invasive human ovarian cancer in patients with low serum CA125 (show MUC16 Proteins) levels.

  8. stress-inducible protein-1 has a role in recruitment of bone marrow derived cells into the ischemic brains

  9. results show phosphorylation of the C-terminal region of Hsp70 (show HSP70 Proteins) and Hsp90 (show HSP90 Proteins) is critical for the decision between folding or degradation of client proteins by altering the binding of CHIP and HOP; also show increased phosphorylation in cancer cells with increased levels of the co-chaperone HOP

  10. Luminal iron levels govern intestinal tumorigenesis after Apc (show APC Proteins) loss in vivo.

Stress-Induced-phosphoprotein 1 (STIP1) Protein Profile

Protein Summary

STIP1 is an adaptor protein that coordinates the functions of HSP70 (see HSPA1A\; MIM 140550) and HSP90 (see HSP90AA1\; MIM 140571) in protein folding. It is thought to assist in the transfer of proteins from HSP70 to HSP90 by binding both HSP90 and substrate-bound HSP70. STIP1 also stimulates the ATPase activity of HSP70 and inhibits the ATPase activity of HSP90, suggesting that it regulates both the conformations and ATPase cycles of these chaperones (Song and Masison, 2005

Gene names and symbols associated with STIP1

  • stress-induced-phosphoprotein 1 (stip1)
  • stress-induced-phosphoprotein 1 (STIP1)
  • Stress-induced-phosphoprotein 1 (GL50803_27310)
  • stress-induced-phosphoprotein 1 (PGTG_06468)
  • stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing protein) (stip1)
  • stress-induced phosphoprotein 1 (Stip1)
  • tuftelin interacting protein 11 (tfip11)
  • HOP protein
  • IEF-SSP-3521 protein
  • MGC53256 protein
  • MGC76181 protein
  • MGC82554 protein
  • P60 protein
  • STI1 protein
  • STI1L protein
  • stip protein
  • stip1 protein
  • zgc:92133 protein

Protein level used designations for STIP1

stress-induced-phosphoprotein 1 , stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing protein) , Stress-induced-phosphoprotein 1 , Hsp70/Hsp90 organizing protein , IEF SSP 3521 , hsc70/Hsp90-organizing protein , mSTI1 , stress-inducible protein , STI1 , hop , Hsc70/Hsp90-organizing protein , Hsp70/Hsp90-organizing protein , NY-REN-11 antigen , renal carcinoma antigen NY-REN-11 , transformation-sensitive protein IEF SSP 3521 , STIP-1 , septin and tuftelin-interacting protein 1 , tuftelin-interacting protein 11

379955 Xenopus laevis
451286 Pan troglodytes
717926 Macaca mulatta
5697231 Giardia lamblia ATCC 50803
10539523 Puccinia graminis f. sp. tritici CRL 75-36-700-3
100356266 Oryctolagus cuniculus
394990 Xenopus (Silurana) tropicalis
447010 Xenopus laevis
493606 Danio rerio
20867 Mus musculus
192277 Rattus norvegicus
100689413 Cricetulus griseus
10963 Homo sapiens
474837 Canis lupus familiaris
617109 Bos taurus
447466 Xenopus laevis
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