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STIM1 encodes a type 1 transmembrane protein that mediates Ca2+ influx after depletion of intracellular Ca2+ stores by gating of store-operated Ca2+ influx channels (SOCs). Additionally we are shipping STIM1 Antibodies (152) and STIM1 Proteins (19) and many more products for this protein.
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Human STIM1 ELISA Kit for Sandwich ELISA - ABIN824174
Wang, Sun, Huang, Wang, Hou, Sun, He, Krishna, Chiu, Lin, Yang, Chang: STIM1 overexpression promotes colorectal cancer progression, cell motility and COX-2 expression. in Oncogene 2014
Downregulation of STIM1 levels in oocytes by siRNA completely inhibited the repetitive Ca(2 (show CA2 ELISA Kits)+) signal triggered by the fertilizing sperm.
findings suggest that in oocytes, STIM1 serves as a sensor of Ca(2 (show CA2 ELISA Kits)+) store content that after store depletion moves to the plasma membrane to stimulate store-operated Ca(2 (show CA2 ELISA Kits)+) entry
STIM1 plays role in PAR1 (show F2R ELISA Kits)-mediated Ca2 (show CA2 ELISA Kits)+ influx and Ca2 (show CA2 ELISA Kits)+-dependent NO production in endothelial cells; DNA sequence alignment of porcine and human STIM1
STIM1 is localized to the cleavage furrow during cytokinesis of the first and second cell division cycles in zebrafish embryos.
STIM1/TRPC1 (show TRPC1 ELISA Kits)-dependent store-operated Ca2 (show CA2 ELISA Kits)+ entry plays an essential role in generating spatiotemporal Ca2 (show CA2 ELISA Kits)+ signals that mediate guidance responses of nerve growth cones.
STIM1 and Orai1 (show ORAI1 ELISA Kits) are essential components of the signal transduction cascade that regulates sex pheromone production.
Mutations in the STIM1 and ORAI1 (show ORAI1 ELISA Kits) genes cause calcium dyshomeostasis in tubular aggregate myopathy. (Review)
STIM1 knockdown did not alter proliferation or apoptosis, but promoted cell adhesion and inhibited migration and invasion in the gastric cancer cells. STIM1 knockdown did not alter the expression or phosphorylation of mitogen-activated protein kinase (show MAPK1 ELISA Kits) (MEK (show MAP2K1 ELISA Kits)) or extracellular signal-regulated kinase (ERK (show EPHB2 ELISA Kits)), implying that STIM1 affected gastric cancer cell migration through a pathway independent of the MEK (show MAP2K1 ELISA Kits)/ERK (show EPHB2 ELISA Kits) pathway.
SARAF (show TMEM66 ELISA Kits) overexpression attenuated store operated Ca2 (show CA2 ELISA Kits)+ entry and the STIM1-Orai1 (show ORAI1 ELISA Kits) interaction in cells endogenously expressing STIM1 and Orai1 (show ORAI1 ELISA Kits) while RNAi-mediated SARAF (show TMEM66 ELISA Kits) silencing induced opposite effects.
Calsequestrin-1 (show CASQ1 ELISA Kits) monomers suppress Store-Operated Ca2 (show CA2 ELISA Kits)+ Entry by interacting with STIM1 and attenuating STIM1 aggregation via its C-terminal amino acid 362-396.
the STIM1-Orai1 (show ORAI1 ELISA Kits) system has a role in intra-cellular calcium elevation induced by ATP in cultured human keratinocytes
Coupling of the endoplasmic reticulum (ER) Ca(2 (show CA2 ELISA Kits)+)sensor, stromal interaction molecule 1 (STIM1), to the Ca(2 (show CA2 ELISA Kits)+)-selective channel, Orai1 (show ORAI1 ELISA Kits), is regulated by these elements and depends on membrane organization, both at the plasma membrane and at the ER
STIM11-469 and Orai1 (show ORAI1 ELISA Kits) W76A mutants do not reduce channel open probability.
T Cell Receptor-induced Nuclear Factor kappaB (NF-kappaB (show NFKB1 ELISA Kits)) Signaling and Transcriptional Activation Are Regulated by STIM1- and Orai1 (show ORAI1 ELISA Kits)-mediated Calcium Entry.
study reports recessive STIM1 mutations in patients presenting with amelogenesis imperfecta and hypohidrosis without overt clinical immunodeficiency or myopathy
Data suggest that stromal interaction molecule 1 (STIM1) may be developed as a potential therapeutic target of cancer treatment.
STIM1 and STIM2 (show Stim2 ELISA Kits) are expressed in bovine aortic endothelial cells and they both interact with IP3R-1 (show ITPR1 ELISA Kits).
Data show that the STIM1 Ksp (Eg5 (show KIF11 ELISA Kits))-cre knockout mice produced more urine compared to control.
We conclude that STIM1 has an unexpected function in the heart where it alters communication between the sarcolemma and sarcoplasmic reticulum resulting in greater Ca(2 (show CA2 ELISA Kits)+) flux and a leaky SR compartment.
Stim1 silencing prevented mTOR complex 2 phosphorylation of Akt(S473) via a direct interaction between STIM1 and Rictor. This represses GSK-3beta activity and prevents/reverses cardiac hypertrophy.
role of STIM1, Orai1 (show TMEM132A ELISA Kits) and TRPCs, and thus SOCE, in thrombus formation, suggests that therapies directed against SOCE and targeting these molecules during cardiovascular and cerebrovascular events could improve traditional anti-thrombotic treatments
Quantitative Proteomics Reveals the Essential Roles of Stromal Interaction Molecule 1 (STIM1) in the Testicular Cord Formation in Mouse Testis
Results show the cytoplasmic domain of STIM1 as a target for calpains which cleave STIM1 to control its cellular abundance. Furthermore, STIM1's susceptibility to calpain cleavage leads to enhanced STIM1 degradation during the progression of apoptosis.
Orai1 (show TMEM132A ELISA Kits) and STIM1 have roles in inhibiting matrix protein expression
STIM1 plays opposing roles in vascular smooth muscle vs. endothelial cells in the regulation of vascular reactivity.
STIM1 is a multifunctional regulator of Ca(2 (show CA2 ELISA Kits)+) dynamics in SANCs that links SR Ca(2 (show CA2 ELISA Kits)+) store content with electrical events occurring in the plasma membrane, thereby contributing to automaticity of the SAN
STIM1L does not mediate rapid store-operated Ca(2 (show CA2 ELISA Kits)+) entry but can trap and gate Orai1 (show TMEM132A ELISA Kits) channels efficiently without remodeling cortical ER cisternae.
This gene encodes a type 1 transmembrane protein that mediates Ca2+ influx after depletion of intracellular Ca2+ stores by gating of store-operated Ca2+ influx channels (SOCs). It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region, as well as early hematopoiesis, by mediating attachment to stromal cells. This gene is oriented in a head-to-tail configuration with the ribonucleotide reductase 1 gene (RRM1), with the 3' end of this gene situated 1.6 kb from the 5' end of the RRM1 gene.
stromal interaction molecule 1
, stromal interaction molecule 1b