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Stim2 is a member of the stromal interaction molecule (STIM) family and likely arose, along with related family member STIM1, from a common ancestral gene. Additionally we are shipping Stim2 Antibodies (72) and many more products for this protein.
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The STIM2 protein play important roles in TGF-beta (show TGFB1 Proteins)-induced EMT (show ITK Proteins) and these effects are related to both store-operated calcium entry and non-store-operated calcium entry.
What is less clear is how the spatial and temporal spread of intracellular Ca(2 (show CA2 Proteins)+) is shaped and regulated by differential expression of the individual SOCE genes and their splice variants, their heteromeric combinations and pre- and posttranslational modifications. This review focuses on principle mechanisms regulating expression, splicing, and targeting of Ca(2 (show CA2 Proteins)+) release-activated Ca(2 (show CA2 Proteins)+) (CRAC) channels.
While STIM1 is a full Orai1-agonist, leucine-replacement of this crucial residue in STIM2 endows it with partial agonist properties, which may be critical for limiting Orai1 activation stemming from its enhanced sensitivity to store-depletion
STIM2.1 cannot activate Orai1 due to splicing in residues within the channel-activating domain (CAD). STIM2.1 confers a calcium dependent dominant-negative function on both STIM1 and STIM2 (STIM2.2). Affinity of the STIM2.1 calmodulin binding site within the CAD domain is increased compared to STIM2.2.
STIM2 enhances receptor-stimulated Ca(2 (show CA2 Proteins)) signaling by promoting recruitment of STIM1 (show STIM1 Proteins) to the endoplasmic reticulum-plasma membrane junctions.
STIM2beta does not by itself strongly bind Orai1, it is recruited to Orai1 channels by forming heterodimers with other STIM isoforms.
Imin channels are regulated by STIM2, TRPC3 (show TRPC3 Proteins)-containing INS (show INS Proteins) channels are induced by STIM1 (show STIM1 Proteins), and TRPC1 (show TRPC1 Proteins)-composed Imax channels are activated by both STIM1 (show STIM1 Proteins) and STIM2.
The higher amplitude of store-operated Ca2 (show CA2 Proteins)+ entry was associated to the over-expression for Stim2, Orai2 (show ORAI2 Proteins)-3, and TRPC1 (show TRPC1 Proteins) while Stim2 levels remained constant and Stim1 (show STIM1 Proteins), Orai1, Orai3, TRPC1 (show TRPC1 Proteins) and TRPC4 (show TRPC4 Proteins) proteins were over-expressed in primary myelofibrosis.
the reciprocal shift in transient receptor potential channel 1 (TRPC1 (show TRPC1 Proteins)) and stromal interaction molecule 2 (STIM2) contributes to Ca2 (show CA2 Proteins)+ remodeling and cancer hallmarks in colorectal carcinoma cells
STIM2 is highly expressed and controls store-operated Ca(2 (show CA2 Proteins)+) entry in human melanoma. The invasive and migratory potential of melanoma cells was reduced upon silencing of STIM2.
Expression of STIM2 protein rescued CaMKII (show CAMK2G Proteins) activity and protected mushroom spines from Abeta42 oligomer toxicity in vitro and in vivo.
SOCE blockers or ablation of STIM1, STIM2, or Orai1 severely impaired nucleotide-induced migration and phagocytosis in microglia.
The data from this study indicate that upregulation of STIM2 and Orai2 (show ORAI2 Proteins) is involved in the phenotypic transition of pulmonary arterial smooth muscle cells from a contractile state to a proliferative state.
STIM1 (show STIM1 Proteins), STIM2, and CRAC channel function play distinct but synergistic roles in CD4 (show CD4 Proteins)+ and CD8 (show CD8A Proteins)+ T cells during antiviral immunity
STIM2 deficiency significantly delays onset and attenuates the clinical course of experimental allergic encephalitis.
Using mice lacking STIM1 (show STIM1 Proteins) and its homologue STIM2, authors find that store-operated calcium entry in CD8 (show CD8A Proteins)(+) T cells is required to prevent the engraftment of melanoma and colon carcinoma cells and to control tumour growth.
STIM1 (show STIM1 Proteins) and STIM2-mediated store-operated Ca2 (show CA2 Proteins)+ influx, leading to efficient activation of NFAT (show NFATC1 Proteins) (nuclear factor of activated T cells), is critical for the postselection maturation of agonist-selected T cells.
STIM1 (show STIM1 Proteins) and STIM2 protein deficiency in T lymphocytes underlies development of the exocrine gland autoimmune disease, Sjogren's syndrome.
show that endoplasmic reticulum calcium sensors STIM1 (show STIM1 Proteins)- and STIM2-induced store-operated Ca(2 (show CA2 Proteins)+) influx is critical for B cell regulatory function
Absence of STIM2 in mouse embryonic fibroblasts results in a decreased store-operated calcium ion entry, although this inhibition is less pronounced than for STIM1 (show STIM1 Proteins).
This gene is a member of the stromal interaction molecule (STIM) family and likely arose, along with related family member STIM1, from a common ancestral gene. The encoded protein functions to regulate calcium concentrations in the cytosol and endoplasmic reticulum, and is involved in the activation of plasma membrane Orai Ca(2+) entry channels. This gene initiates translation from a non-AUG (UUG) start site. A signal peptide is cleaved from the resulting protein. Multiple transcript variants result from alternative splicing.
stromal interaction molecule 2