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anti-Structural Maintenance of Chromosomes 1A (SMC1A) Antibodies

Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. Additionally we are shipping SMC1A Kits (7) and SMC1A Proteins (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SMC1A 8243 Q14683
SMC1A 24061 Q9CU62
SMC1A 63996 Q9Z1M9
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Top anti-SMC1A Antibodies at antibodies-online.com

Showing 10 out of 209 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Chicken Rabbit Un-conjugated WB WB Suggested Anti-SMC1A Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:1562500Positive Control: 293T cell lysate Host: Rabbit  Target Name: SMC1A  Sample Tissue: Human HepG2  Antibody Dilution: 1.0 µg/mL SMC1A is supported by BioGPS gene expression data to be expressed in HepG2 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated FACS, IHC, WB SMC1A antibody at 1/200 dilution, Neuclear extracts of HeLa cell 40ug/Lane, Predicted band size: 150kDa, Observed band size: 150kDa IHC of paraffin-embedded human colon using anti-SMC1A (N-terminus) diluted 1/500-1/1000. 100 μL Log in to see 8 to 9 Days
$392.86
Details
Human Rabbit Un-conjugated IHC (p), IP, WB 0.1 mg Log in to see 6 to 8 Days
$940.50
Details
Human Rabbit Un-conjugated IP, WB 0.1 mg Log in to see 6 to 8 Days
$984.50
Details
Human Mouse Un-conjugated ICC, FACS, IHC, ELISA, WB Figure 1: Flow cytometric analysis of Hela cells using SMC1 mouse mAb (green) and negative control (purple) . Figure 2: Immunofluorescence analysis of NIH/3T3 cells using SMC1 mouse mAb (green) . Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin. 100 μL Log in to see 3 to 4 Days
$393.80
Details
Human Rabbit Un-conjugated IHC (p) 0.1 mL Log in to see 6 to 8 Days
$308.00
Details
Human Rabbit Un-conjugated IHC (p) 0.1 mL Log in to see 6 to 8 Days
$357.50
Details
Human Rabbit Un-conjugated WB SMC1A Antibody (N-term) (ABIN657467) western blot analysis in CEM cell line lysates (35 µg/lane). This demonstrates the SMC1A antibody detected the SMC1A protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Mouse Un-conjugated IF, WB 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Human Rabbit Un-conjugated IHC (p) 0.1 mg Log in to see 6 to 8 Days
$390.50
Details

SMC1A Antibodies by Reactivity, Application, Clonality and Conjugate

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Top referenced anti-SMC1A Antibodies

  1. Human Polyclonal SMC1A Primary Antibody for IHC (p) - ABIN196936 : Yang, Mehta, Uzri, Jayaram, Velmurugan: Mutations in a partitioning protein and altered chromatin structure at the partitioning locus prevent cohesin recruitment by the Saccharomyces cerevisiae plasmid and cause plasmid missegregation. in Molecular and cellular biology 2004 (PubMed)
    Show all 3 references for ABIN196936

  2. Human Monoclonal SMC1A Primary Antibody for IF, WB - ABIN264420 : Eijpe, Heyting, Gross, Jessberger: Association of mammalian SMC1 and SMC3 proteins with meiotic chromosomes and synaptonemal complexes. in Journal of cell science 2000 (PubMed)
    Show all 3 references for ABIN264420

  3. Human Polyclonal SMC1A Primary Antibody for IHC (p) - ABIN197408 : Kim, Xu, Kastan: Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage. in Genes & development 2002 (PubMed)
    Show all 3 references for ABIN197408

  4. Human Polyclonal SMC1A Primary Antibody for IP, WB - ABIN318942 : Jones, Sgouros: The cohesin complex: sequence homologies, interaction networks and shared motifs. in Genome biology 2001 (PubMed)
    Show all 2 references for ABIN318942

  5. Human Monoclonal SMC1A Primary Antibody for ICC, FACS - ABIN969406 : Kim, Choi, Kim, Woo, Chung: Reoxygenation following hypoxia activates DNA-damage checkpoint signaling pathways that suppress cell-cycle progression in cultured human lymphocytes. in FEBS letters 2007 (PubMed)

  6. Human Monoclonal SMC1A Primary Antibody for FACS, IHC - ABIN488213 : Paech, Webb, Kuiper, Nilsson, Gustafsson, Kushner, Scanlan: Differential ligand activation of estrogen receptors ERalpha and ERbeta at AP1 sites. in Science (New York, N.Y.) 1997 (PubMed)

  7. Chicken Polyclonal SMC1A Primary Antibody for WB - ABIN2780766 : Barber, McManus, Yuen, Reis, Parmigiani, Shen, Barrett, Nouhi, Spencer, Markowitz, Velculescu, Kinzler, Vogelstein, Lengauer, Hieter: Chromatid cohesion defects may underlie chromosome instability in human colorectal cancers. in Proceedings of the National Academy of Sciences of the United States of America 2008 (PubMed)

More Antibodies against SMC1A Interaction Partners

Zebrafish Structural Maintenance of Chromosomes 1A (SMC1A) interaction partners

  1. zebrafish embryos and SMC1A-mutated pa (show NIPBL Antibodies)tient-derived fibroblasts were used to analyze abnormalities induced by SMC1A loss of function

Human Structural Maintenance of Chromosomes 1A (SMC1A) interaction partners

  1. Loss-of-function mutations of SMC1A may be associated with early-onset encephalopathy with epilepsy.

  2. numerous dysregulated genes occupied by cohesin by combining the transcriptome of CdLS (show NIPBL Antibodies) cell lines carrying mutations in SMC1A gene, were identified.

  3. two novel de novo heterozygous frameshift mutations in the SMC1A gene were identified in two patients with developmental delay and epilepsy.

  4. Our findings identify both SMC1 and CTCF (show CTCF Antibodies) as critical regulators of the differentiation-dependent life cycle of high-risk human papillomaviruses

  5. same down-regulation of cohesin target (show NIPBL Antibodies)s is observed in SMC1A-mutated patient fibroblasts

  6. Results show that SMC1A is overexpressed in colorectal cancer tissues and correlated with poor prognosis for late stage disease.

  7. The SMC1a mutation leads to chromosomal instability and tumorigenesis in early colorectal adenomas.

  8. A dominant negative effect is considered the pathogenic mechanism in SMC1A-defective female patients, the level of allelic preferential expression might be one of the factors contributing to the wide phenotypic variability observed in these patients.

  9. Clinical comparison between our patient with a previously reported individual with a SMC1A duplication and four male carriers of similar sSMC reported in databases, suggest that they all share clinical features related to cohesinopathies

  10. The mutation c.1731G>A/p.E577E in our patient expands the mutational spectrum of SMC1A to splice site mutations and also represents the first exonic synonymous splice site mutation observed in any human cohesinopathy

Mouse (Murine) Structural Maintenance of Chromosomes 1A (SMC1A) interaction partners

  1. expression analysis of Smc1a and Nipbl (show NIPBL Antibodies) in developing mouse embryos reveals a specific pattern in the hindbrain

  2. SMC1A participates in tissue-specific enhancer-promoter interactions and interactions that demarcate regions of correlated regulatory output.

  3. Point mutation at the Nbs1 (show NBN Antibodies) Threonine 278 site does not affect mouse development, but compromises the Chk2 (show CHEK2 Antibodies) and Smc1 phosphorylation after DNA damage.

  4. A positively charged channel within the Smc1/Smc3 (show SMC3 Antibodies) hinge required for sister chromatid cohesion.

  5. SMC1alpha is mainly associated with homologous or non-homologous synapsed regions. The protein also localizes along meiotic chromosome cores of Spo11 (show SPO11 Antibodies) null spermatocytes.

  6. observations suggest that many of the abnormal stress responses seen in cells lacking ATM (show ATM Antibodies), NBS1 (show NBN Antibodies), or BRCA1 (show BRCA1 Antibodies) result from a failure of ATM (show ATM Antibodies) migration to sites of DNA breaks and a resultant lack of SMC1 phosphorylation.

  7. SMC1beta (show SMC1B Antibodies) was found along the axial elements of synaptonemal complexes in prophase I of testis sections and chromosome spreads . Thus, SMC1beta (show SMC1B Antibodies) and not SMC1alpha is likely involved in maintaining cohesion between sister centromeres until anaphase II.

Cow (Bovine) Structural Maintenance of Chromosomes 1A (SMC1A) interaction partners

SMC1A Antigen Profile

Protein Summary

Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1L2 or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation.

Gene names and symbols associated with SMC1A

  • structural maintenance of chromosomes 1A, like (smc1al) antibody
  • structural maintenance of chromosomes 1A (SMC1A) antibody
  • structural maintenance of chromosomes 1B (SMC1B) antibody
  • SMC1 structural maintenance of chromosomes 1-like 2 (LOC100337867) antibody
  • structural maintenance of chromosomes 1A (Smc1a) antibody
  • structural maintenance of chromosomes 1A (smc1a) antibody
  • structural maintenance of chromosomes 1A b (smc1ab) antibody
  • 5830426I24Rik antibody
  • CDLS2 antibody
  • DXS423E antibody
  • im:7158706 antibody
  • mKIAA0178 antibody
  • NV15570 antibody
  • Sb1.8 antibody
  • SMC-1A antibody
  • smc1 antibody
  • smc1a antibody
  • smc1aa antibody
  • Smc1alpha antibody
  • Smc1l1 antibody
  • SMC1L2 antibody
  • Smcb antibody
  • xSMC1 antibody
  • zgc:76902 antibody

Protein level used designations for SMC1A

SMC1 structural maintenance of chromosomes 1-like 1 , SMC1 structural maintenance of chromosomes 1-like 2 , structural maintenance of chromosomes 1A , structural maintenance of chromosomes protein 1A-like , SMC protein 1A , SMC-1-alpha , SMC1 (structural maintenance of chromosomes 1, yeast)-like 1 , segregation of mitotic chromosomes 1 , structural maintenance of chromosomes protein 1A , SMC (segregation of mitotic chromosomes 1)-like 1 , chromosome segregation protein SmcB , segregation of mitotic chromosomes b , SMC-like 1 , structural maintenance of chromosomes 1A a , SMC1 protein cohesin subunit , structural maintenance of chromosomes 1 , SMC-protein , DXhXs423e , segregation of mitotic chromosomes-like 1 , structural maintenance of chromosomes 1 like 1 , 14S cohesin SMC1 subunit

GENE ID SPECIES
403060 Danio rerio
677711 Macaca mulatta
418243 Gallus gallus
458907 Pan troglodytes
100337867 Oryctolagus cuniculus
473619 Pan troglodytes
100120122 Nasonia vitripennis
100402111 Callithrix jacchus
100458659 Pongo abelii
8243 Homo sapiens
24061 Mus musculus
559665 Danio rerio
380182 Xenopus laevis
395187 Gallus gallus
480928 Canis lupus familiaris
282370 Bos taurus
63996 Rattus norvegicus
100379087 Xenopus laevis
Selected quality suppliers for anti-SMC1A (SMC1A) Antibodies
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