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Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. Additionally we are shipping SMC1A Kits (7) and SMC1A Proteins (4) and many more products for this protein.
Showing 10 out of 218 products:
Human Polyclonal SMC1A Primary Antibody for ELISA, ICC - ABIN151508
Udayakumar, Bladen, Hudson, Dynan: Distinct pathways of nonhomologous end joining that are differentially regulated by DNA-dependent protein kinase-mediated phosphorylation. in The Journal of biological chemistry 2003
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Human Polyclonal SMC1A Primary Antibody for ELISA, ICC - ABIN151528
Leung-Pineda, Ryan, Piwnica-Worms: Phosphorylation of Chk1 by ATR is antagonized by a Chk1-regulated protein phosphatase 2A circuit. in Molecular and cellular biology 2006
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Human Polyclonal SMC1A Primary Antibody for IHC (p) - ABIN196936
Yang, Mehta, Uzri, Jayaram, Velmurugan: Mutations in a partitioning protein and altered chromatin structure at the partitioning locus prevent cohesin recruitment by the Saccharomyces cerevisiae plasmid and cause plasmid missegregation. in Molecular and cellular biology 2004
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Human Polyclonal SMC1A Primary Antibody for IHC (p) - ABIN197408
Kim, Xu, Kastan: Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage. in Genes & development 2002
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Human Polyclonal SMC1A Primary Antibody for IP, WB - ABIN318942
Jones, Sgouros: The cohesin complex: sequence homologies, interaction networks and shared motifs. in Genome biology 2001
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Human Monoclonal SMC1A Primary Antibody for FACS, IHC - ABIN488213
Paech, Webb, Kuiper, Nilsson, Gustafsson, Kushner, Scanlan: Differential ligand activation of estrogen receptors ERalpha and ERbeta at AP1 sites. in Science (New York, N.Y.) 1997
Human Monoclonal SMC1A Primary Antibody for ICC, FACS - ABIN969406
Kim, Choi, Kim, Woo, Chung: Reoxygenation following hypoxia activates DNA-damage checkpoint signaling pathways that suppress cell-cycle progression in cultured human lymphocytes. in FEBS letters 2007
Chicken Polyclonal SMC1A Primary Antibody for WB - ABIN2780766
Barber, McManus, Yuen, Reis, Parmigiani, Shen, Barrett, Nouhi, Spencer, Markowitz, Velculescu, Kinzler, Vogelstein, Lengauer, Hieter: Chromatid cohesion defects may underlie chromosome instability in human colorectal cancers. in Proceedings of the National Academy of Sciences of the United States of America 2008
zebrafish embryos and SMC1A-mutated pa (show NIPBL Antibodies)tient-derived fibroblasts were used to analyze abnormalities induced by SMC1A loss of function
Results showed that the high expression of SMC1 often promoted epithelial-mesenchymal transition, accompanied by the enhanced expression of Brachyury (show TBX1 Antibodies) in triple-negative breast cancer cells.
SMC1A plays an oncogenic role in colorectal cancer.
Loss-of-function mutations of SMC1A may be associated with early-onset encephalopathy with epilepsy.
numerous dysregulated genes occupied by cohesin by combining the transcriptome of CdLS (show NIPBL Antibodies) cell lines carrying mutations in SMC1A gene, were identified.
two novel de novo heterozygous frameshift mutations in the SMC1A gene were identified in two patients with developmental delay and epilepsy.
Our findings identify both SMC1 and CTCF (show CTCF Antibodies) as critical regulators of the differentiation-dependent life cycle of high-risk human papillomaviruses
same down-regulation of cohesin target (show NIPBL Antibodies)s is observed in SMC1A-mutated patient fibroblasts
Results show that SMC1A is overexpressed in colorectal cancer tissues and correlated with poor prognosis for late stage disease.
The SMC1a mutation leads to chromosomal instability and tumorigenesis in early colorectal adenomas.
A dominant negative effect is considered the pathogenic mechanism in SMC1A-defective female patients, the level of allelic preferential expression might be one of the factors contributing to the wide phenotypic variability observed in these patients.
expression analysis of Smc1a and Nipbl (show NIPBL Antibodies) in developing mouse embryos reveals a specific pattern in the hindbrain
SMC1A participates in tissue-specific enhancer-promoter interactions and interactions that demarcate regions of correlated regulatory output.
Point mutation at the Nbs1 (show NBN Antibodies) Threonine 278 site does not affect mouse development, but compromises the Chk2 (show CHEK2 Antibodies) and Smc1 phosphorylation after DNA damage.
A positively charged channel within the Smc1/Smc3 (show SMC3 Antibodies) hinge required for sister chromatid cohesion.
SMC1alpha is mainly associated with homologous or non-homologous synapsed regions. The protein also localizes along meiotic chromosome cores of Spo11 (show SPO11 Antibodies) null spermatocytes.
observations suggest that many of the abnormal stress responses seen in cells lacking ATM (show ATM Antibodies), NBS1 (show NBN Antibodies), or BRCA1 (show BRCA1 Antibodies) result from a failure of ATM (show ATM Antibodies) migration to sites of DNA breaks and a resultant lack of SMC1 phosphorylation.
SMC1beta (show SMC1B Antibodies) was found along the axial elements of synaptonemal complexes in prophase I of testis sections and chromosome spreads . Thus, SMC1beta (show SMC1B Antibodies) and not SMC1alpha is likely involved in maintaining cohesion between sister centromeres until anaphase II.
Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1L2 or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation.
SMC1 structural maintenance of chromosomes 1-like 1
, SMC1 structural maintenance of chromosomes 1-like 2
, structural maintenance of chromosomes 1A
, structural maintenance of chromosomes protein 1A-like
, SMC protein 1A
, SMC1 (structural maintenance of chromosomes 1, yeast)-like 1
, segregation of mitotic chromosomes 1
, structural maintenance of chromosomes protein 1A
, SMC (segregation of mitotic chromosomes 1)-like 1
, chromosome segregation protein SmcB
, segregation of mitotic chromosomes b
, SMC-like 1
, structural maintenance of chromosomes 1A a
, SMC1 protein cohesin subunit
, structural maintenance of chromosomes 1
, segregation of mitotic chromosomes-like 1
, structural maintenance of chromosomes 1 like 1
, 14S cohesin SMC1 subunit