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Structural Maintenance of Chromosomes 5 Proteins (SMC5)

Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. Additionally we are shipping SMC5 Antibodies (36) and SMC5 Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SMC5 23137 Q8IY18
SMC5 226026 Q8CG46
Rat SMC5 SMC5 293967  
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Top SMC5 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

SMC5 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Structural Maintenance of Chromosomes 5 (SMC5) Interaction Partners

Arabidopsis thaliana Structural Maintenance of Chromosomes 5 (SMC5) interaction partners

  1. The SMC5/6 complex promotes sister chromatid cohesion after DNA breakage and facilitates homologous recombination between sister chromatids.

Human Structural Maintenance of Chromosomes 5 (SMC5) interaction partners

  1. results uncover a novel role for the Smc5/6 complex as a restriction factor selectively blocking extrachromosomal DNA transcription; by destroying this complex, HBx relieves the inhibition to allow productive hepatitis B virus gene expression

  2. Structural maintenance of chromosomes (SMC (show DYM Proteins)) complexes, which in eukaryotic cells include cohesin, condensin and the Smc5/6 complex, are central regulators of chromosome dynamics

  3. Depletion of Smc5 and Smc6 (show SMC6 Proteins) resulted in aberrant mitotic chromosome phenotypes that were accompanied by the abnormal distribution of topoisomerase IIalpha (topo IIalpha) and condensins and by chromosome segregation errors

  4. Studies indicate that Nse1 (show FAM84A Proteins) may function as a ubiquitin ligase, and is targeted to chromatin through its interaction with the Smc5/6 complex.

  5. the human SMC5/6 complex and the SUMO ligase activity of hMMS21 (show NSMCE2 Proteins) are required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair in human cells

  6. SMC5/6 complex is recruited to nuclease-induced double-strand breaks (DSBs) and is required for the recruitment of cohesin to DSBs.

  7. SMC5/6 complex facilitates telomere homologous recombination and elongation in alternative lengthening of telomeres cells through SUMOylation of telomere-binding proteins.

  8. The four non-SMC components of the human complex were identified and characterized and it was demonstrated that the MAGEG1 protein is part of this complex.

  9. Nse1 (show FAM84A Proteins) RING-like motif is a protein-protein interaction domain required for Smc5-Smc6 (show SMC6 Proteins) holocomplex integrity and recruitment to, or retention at, DNA lesions

  10. SMC5 is crucial for mitotic progression and maintenance of sister chromatid cohesion during mitosis.

Xenopus laevis Structural Maintenance of Chromosomes 5 (SMC5) interaction partners

  1. The Smc5/6 complex is regulated during the cell cycle, presumably in anticipation of DNA damage that may arise during replication.

SMC5 Protein Profile

Protein Summary

Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components. Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression\; the function seems to be independent of SMC6 (By similarity).

Gene names and symbols associated with SMC5

  • structural maintenance of chromosomes 5 (SMC5)
  • SMC5 protein (smc5)
  • structural maintenance of chromosomes 5 (Smc5)
  • structural maintenance of chromosomes 5 (smc5)
  • F1N13.60 protein
  • F1N13_60 protein
  • mKIAA0594 protein
  • MLZ-453 protein
  • mSMC5 protein
  • SMC-5 protein
  • Smc5l1 protein
  • structural maintenance of chromosomes 5 protein

Protein level used designations for SMC5

SMC protein 5 , structural maintenance of chromosomes protein 5 , SMC-5 , SMC5 structural maintenance of chromosomes 5-like 1 , hSMC5 , protein expressed in male leptotene and zygotene spermatocytes 453

GENE ID SPECIES
831449 Arabidopsis thaliana
445963 Takifugu rubripes
23137 Homo sapiens
476327 Canis lupus familiaris
508938 Bos taurus
226026 Mus musculus
293967 Rattus norvegicus
431608 Gallus gallus
398492 Xenopus laevis
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