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Succinate Dehydrogenase Complex, Subunit A, Flavoprotein (Fp) Proteins (SDHA)

SDHA encodes a major catalytic subunit of succinate-ubiquinone oxidoreductase, a complex of the mitochondrial respiratory chain. Additionally we are shipping Succinate Dehydrogenase Complex, Subunit A, Flavoprotein (Fp) Antibodies (93) and Succinate Dehydrogenase Complex, Subunit A, Flavoprotein (Fp) Kits (7) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SDHA 6389 P31040
SDHA 66945 Q8K2B3
SDHA 157074 Q920L2
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Top Succinate Dehydrogenase Complex, Subunit A, Flavoprotein (Fp) Proteins at antibodies-online.com

Showing 5 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His-SUMO Tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
HOST_Escherichia coli (E. coli) Human GST tag Succinate Dehydrogenase Complex, Subunit A, Flavoprotein (Fp) (SDHA) (AA 44-293), (partial) protein (GST tag) 1 mg Log in to see 56 to 66 Days
$1,842.50
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,793.17
Details

SDHA Proteins by Origin and Source

Origin Expressed in Conjugate
Human
, ,
Mouse (Murine)

Rat (Rattus)

More Proteins for Succinate Dehydrogenase Complex, Subunit A, Flavoprotein (Fp) (SDHA) Interaction Partners

Human Succinate Dehydrogenase Complex, Subunit A, Flavoprotein (Fp) (SDHA) interaction partners

  1. our findings provide further evidence that patients with KIT/PDGFRA (show PDGFRA Proteins) wild-type SDH-deficient GIST harboring SDHA mutations experience good survival outcomes

  2. This study strengthens the etiological association of SDH genes with pituitary neoplasia, renal tumorigenesis, and gastric gastrointestinal stromal tumors. Also, pancreatic neuroendocrine tumor falls within the SDH-related tumor spectrum.

  3. Three novel mutations in SDHA were found in patients presenting Leigh syndrome (LS) and/or leukodystrophy.

  4. Overall, 9 of the 34 patients with KIT/PDGFRA (show PDGFRA Proteins) wild-type GIST carried mutations in one of the four subunits of the SDH complex (six patients in SDHA, two in SDHB (show SDHB Proteins), one in SDHC (show SDHC Proteins)

  5. SDH deficiency may promote tumorigenesis through accumulation of succinate and inhibition of dioxygenase enzymes. Inhibition of TET activity may, in turn, alter global DNA methylation (show HELLS Proteins) and gene expression in SDH-deficient tumors.

  6. Data indicate that SDH5 (show Sdhaf2 Proteins) is protected from mitochondrial LON (show LONP1 Proteins) protease (LONM)-mediated degradation in mitochondria by its stable interaction with SDHA, a state that is dysregulated in hereditary paraganglioma 2 (PGL2 (show Sdhaf2 Proteins)).

  7. Electron transport complex-II and manganese superoxide dismutase (MnSOD (show SOD2 Proteins)) enzyme activities were decreased in obese compared with non-obese pregnant women.

  8. A significant subset of bladder paragangliomas is SDH deficient

  9. SDHA immunohistochemistry on gastrointestinal stromal tumors can identify the presence of an SDHA germline mutation.

  10. Studies indicate that mutations in the mitochondrial complex II structural subunit genes SDHB (show SDHB Proteins), SDHC (show SDHC Proteins) and SDHD (show SDHD Proteins) and the regulatory subunit gene SDHAF2 (show Sdhaf2 Proteins) in many paraganglioma families.

Mouse (Murine) Succinate Dehydrogenase Complex, Subunit A, Flavoprotein (Fp) (SDHA) interaction partners

  1. Tumor-derived FH and SDH (show SDS Proteins) mutations accumulate fumarate and succinate, leading to enzymatic inhibition of multiple alpha-KG-dependent dioxygenases and consequent alterations of genome-wide histone and DNA methylation (show HELLS Proteins).

  2. Data show that SdhA is required for preventing AIM2 (show AIM2 Proteins) inflammasome activation.

  3. Data show that two subunits of complex II (succinate dehydrogenase (show SDHD Proteins), or SDH (show SDS Proteins)), SDHA and SDHB (show SDHB Proteins), interacted specifically with SIRT3 (show SIRT3 Proteins).

  4. Cocaine could inhibit the activities of ATPase, LDH and SDH (show SDS Proteins) in cultured splenocytes.

Succinate Dehydrogenase Complex, Subunit A, Flavoprotein (Fp) (SDHA) Protein Profile

Protein Summary

This gene encodes a major catalytic subunit of succinate-ubiquinone oxidoreductase, a complex of the mitochondrial respiratory chain. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. Mutations in this gene have been associated with a form of mitochondrial respiratory chain deficiency known as Leigh Syndrome. A pseudogene has been identified on chromosome 3q29.

Gene names and symbols associated with SDHA

  • Succinate dehydrogenase A (SdhA)
  • succinate dehydrogenase complex, subunit A, flavoprotein (Fp) (SDHA)
  • succinate dehydrogenase complex, subunit A, flavoprotein (Fp) (Sdha)
  • succinate dehydrogenase complex, subunit A, flavoprotein (Fp) (sdha)
  • 1500032O14Rik protein
  • 2310034D06Rik protein
  • 4921513A11 protein
  • C81073 protein
  • CG17246 protein
  • CMD1GG protein
  • Dmel\\CG17246 protein
  • Fp protein
  • im:7141001 protein
  • PGL5 protein
  • scs-fp protein
  • sdh protein
  • SDH1 protein
  • SDH2 protein
  • Sdha protein
  • sdha-b protein
  • SDHF protein
  • zgc:56051 protein

Protein level used designations for SDHA

CG17246-PA , CG17246-PB , CG17246-PC , COMPLEX II: flavoprotein subunit , SUCCINYL COENZIME A SYNTHETASE FLAVOPROTEIN SUBUNIT , SdhA-PA , SdhA-PB , SdhA-PC , succinate dehydrogenase , succinate dehydrogenase A , succinate dehydrogenase flavoprotein , succinate dehydrogenase flavoprotein subunit , succinyl coenzyme A synthetase flavoprotein subunit , flavoprotein subunit of complex II , succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial , succinate dehydrogenase complex flavoprotein subunit , fp , succinate dehydrogenase complex subunit A , succinate dehydrogenase flavoprotein subunit A , succinate dehydrogenase Fp subunit , Flavoprotein subunit of complex II , Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial , mitochondrial succinate dehydrogenase complex subunit A , succinate dehydrogenase complex subunit A flavoprotein , flavoprotein subunit of complex II B , succinate dehydrogenase [ubiquinone] flavoprotein subunit B, mitochondrial

GENE ID SPECIES
37228 Drosophila melanogaster
6389 Homo sapiens
66945 Mus musculus
157074 Rattus norvegicus
393884 Danio rerio
281480 Bos taurus
395758 Gallus gallus
780433 Sus scrofa
380463 Xenopus laevis
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