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SIKE interacts with IKK-epsilon (IKBKE\\\\; MIM 605048) and TBK1 (MIM 604834) and acts as a suppressor of TLR3 (MIM 603029) and virus-triggered interferon activation pathways (Huang et al., 2005 [PubMed 16281057]).[supplied by OMIM, Mar 2008].. Additionally we are shipping Suppressor of IKBKE 1 Antibodies (39) and Suppressor of IKBKE 1 Proteins (8) and many more products for this protein.
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Data indicate that suppressor of IKKepsilon (show IKBKE ELISA Kits) (SIKE) inhibits TANK-binding kinase 1 (TBK1 (show TBK1 ELISA Kits))-mediated phosphorylation of interferon regulatory factor 3 (IRF3 (show IRF3 ELISA Kits)), which is essential to type I interferon (show IFNA ELISA Kits) production.
Overexpression of SIKE inhibits virus- and Toll-like receptor 3 (show TLR3 ELISA Kits)-triggered interferon (show IFNA ELISA Kits)-stimulated response elements (ISRE) but not NF-kappa B (show NFKB1 ELISA Kits) activation.
SIKE interacts with IKK-epsilon (IKBKE\; MIM 605048) and TBK1 (MIM 604834) and acts as a suppressor of TLR3 (MIM 603029) and virus-triggered interferon activation pathways (Huang et al., 2005
suppressor of IKK epsilon
, suppressor of IKK-epsilon
, Suppressor of IKK-epsilon