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Suppressor of Variegation 3-9 Homolog 1 (Drosophila) Proteins (SUV39H1)

SUV39H1 is a member of the suppressor of variegation 3-9 homolog family and encodes a protein with a chromodomain and a C-terminal SET domain. Additionally we are shipping Suppressor of Variegation 3-9 Homolog 1 (Drosophila) Antibodies (90) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SUV39H1 6839 O43463
SUV39H1 20937 O54864
Rat SUV39H1 SUV39H1 302553  
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Top Suppressor of Variegation 3-9 Homolog 1 (Drosophila) Proteins at antibodies-online.com

Showing 7 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
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HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
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HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
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Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$3,144.17
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Yeast Pongo abelii His tag   1 mg Log in to see 56 to 66 Days
$3,144.17
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Yeast Xenopus laevis His tag   1 mg Log in to see 56 to 66 Days
$3,173.50
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HOST_Escherichia coli (E. coli) Human GST tag SUV39H1 activity assay. Recombinant SUV39H1 activity measured using a fluorescent histone H3 lysine 9 methyltransferase assay. SUV39H1 protein gel. SUV39H1 (4.2 μg) run on a 10% SDS-PAGE gel and stained with Coomassie blue. Arrow indicates recombinant SUV39H1. 25 μg Log in to see 1 to 2 Days
$455.00
Details

SUV39H1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Suppressor of Variegation 3-9 Homolog 1 (Drosophila) (SUV39H1) Interaction Partners

Human Suppressor of Variegation 3-9 Homolog 1 (Drosophila) (SUV39H1) interaction partners

  1. we describe the synthesis of multidomain 'designer chromatin' templates and their application to dissecting the regulation of human Suv39h1

  2. These results suggest a model in which SUV39H1 downregulation promotes the establishment of cellular senescence.

  3. CRL4B promotes tumorigenesis by coordinating with SUV39H1/HP1 (show DEFA1 Proteins)/DNMT3A (show DNMT3A Proteins) in DNA methylation (show HELLS Proteins)-based epigenetic silencing

  4. PHF2 (show PHF1 Proteins) is likely to repress rDNA transcription by competing with PHF8 (show PHF8 Proteins) for binding of ribosomal DNA promoter and by recruiting H3K9me2/3 methyltransferase SUV39H1.

  5. High SUV39H1 expression is associated with hepatocellular carcinoma.

  6. Suv39H1 induced apoptosis and inhibited cell proliferation in the gastric cancer MGC803 cell line, while decreasing BCL-2 (show BCL2 Proteins), pro-caspase-9 (show CASP9 Proteins), pro-caspase-3 (show CASP3 Proteins) and C-myc (show MYC Proteins). Suv39H1 may be a potential gene target for anti-gastric carcinoma therapy.

  7. SUV39H1 expression was upregulated in glioma cell lines and in glioma tissues compared to normal brain, being positively correlated with grade and histological malignancy.

  8. Short-chain fatty acids from periodontal pathogens suppress EZH2 (show EZH2 Proteins), and SUV39H1 to promote Kaposi's sarcoma-associated herpesvirus replication.

  9. Results suggest that by regulating JMJD2b and SUV39H1 expression, p53 (show TP53 Proteins) not only controls transcription but also promotes HC relaxation to accelerate a rate-limiting step in the repair of complex genomes.

  10. The SUV39H1 chromodomain was shown to recognize histone H3K9me2/3 specifically.

Mouse (Murine) Suppressor of Variegation 3-9 Homolog 1 (Drosophila) (SUV39H1) interaction partners

  1. Oct4P4 lncRNA forms a complex with the SUV39H1 HMTase to direct the imposition of H3K9me3 and HP1alpha (show CBX5 Proteins) to the promoter of the ancestral Oct4 (show POU5F1 Proteins) gene, located on chromosome 17, leading to gene silencing and reduced mESC self-renewal.

  2. Provide genetic evidence that Suv39h1 controls telomere homeostasis and mediates resistance to oncogenic stress in vivo, conferring resistance to skin carcinogenesis.

  3. Repeat-associated, Suv39h-dependent H3K9me3 displays a dynamic distribution that differs in the epigenome of pluripotent versus more committed cells.

  4. These findings indicate that Suv39h1 enhances AP-2alpha (show TFAP2A Proteins)-mediated transcriptional repression of C/EBPalpha (show CEBPA Proteins) in an epigenetic manner and further inhibits adipocyte differentiation.

  5. A-type lamins interact with SUV39H1, and prelamin A/progerin exhibits enhanced binding capacity to SUV39H1, protecting it from proteasomal degradation and, consequently, increasing H3K9me3 levels.

  6. Data indicate that loss of suv39h1 prevents Myc (show MYC Proteins)-induced chromosomal instability.

  7. Smads recruit H3K9 methyltransferases Suv39h1 to the IL-2 (show IL2 Proteins) promoter, thereby inducing suppressive histone methylation and inhibiting T cell receptor-mediated IL-2 (show IL2 Proteins) transcription.

  8. SirT1 (show SIRT1 Proteins) preserves heterochromatin structure: it modulates Suv39h1 protein levels in stress conditions by preventing MDM2 (show MDM2 Proteins)-mediated polyubiquitination at K87.

  9. novel role for microRNA in the epigenetic regulation of inflammatory genes in vascular smooth muscle cells of diabetic mice through downregulation of SUV39h1.

  10. Ring1B (show RNF2 Proteins) and Suv39h1 have mutually exclusive roles in regulating distinct chromatin states at key developmental genes, and play a part in how lineage specification can be reinforced during early development

Zebrafish Suppressor of Variegation 3-9 Homolog 1 (Drosophila) (SUV39H1) interaction partners

  1. The identification of a histone H3 (show HIST3H3 Proteins) lysine 9 histone methyltransferase, SUV39H1, as a suppressor of embryonal rhabdomyosarcoma formation in zebrafish, is described.

  2. These results suggest that Dnmt1 (show DNMT1 Proteins) activity helps direct histone methylation by Suv39h1 and that, together, Dnmt1 (show DNMT1 Proteins) and Suv39h1 help guide the terminal differentiation of particular tissues.

Suppressor of Variegation 3-9 Homolog 1 (Drosophila) (SUV39H1) Protein Profile

Protein Summary

This gene is a member of the suppressor of variegation 3-9 homolog family and encodes a protein with a chromodomain and a C-terminal SET domain. This nuclear protein moves to the centromeres during mitosis and functions as a histone methyltransferase, methylating Lys-9 of histone H3. Overall, it plays a vital role in heterochromatin organization, chromosome segregation, and mitotic progression.

Gene names and symbols associated with SUV39H1

  • suppressor of variegation 3-9 homolog 1 (suv39h1)
  • suppressor of variegation 3-9 homolog 1 (Drosophila) (SUV39H1)
  • suppressor of variegation 3-9 homolog 1 (Drosophila) (Suv39h1)
  • suppressor of variegation 3-9 homolog 1a (suv39h1a)
  • AI852103 protein
  • AL022883 protein
  • DXHXS7466e protein
  • fe02c04 protein
  • H3-K9-HMTase 1 protein
  • KMT1A protein
  • MG44 protein
  • mIS6 protein
  • RGD1565028 protein
  • SUV39H protein
  • suv39h1 protein
  • wu:fe02c04 protein
  • zgc:101027 protein

Protein level used designations for SUV39H1

histone-lysine N-methyltransferase SUV39H1 , su(var)3-9 homolog 1 , Su(var)3-9 homolog 1 , histone H3-K9 methyltransferase 1 , histone-lysine N-methyltransferase, H3 lysine-9 specific 1 , lysine N-methyltransferase 1A , position-effect variegation 3-9 homolog , H3-K9-HMTase 1 , Suv39h histone methyltransferase , histone-lysine N-methyltransferase SUV39H1-A , su(var)3-9 homolog 1-A , suppressor of variegation 3-9 homolog 1 , suppressor of variegation 3-9 homolog 1-A , suppressor of variegation 3-9-like 1a

GENE ID SPECIES
431943 Xenopus laevis
6839 Homo sapiens
491868 Canis lupus familiaris
523047 Bos taurus
20937 Mus musculus
302553 Rattus norvegicus
100172621 Pongo abelii
445198 Danio rerio
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