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Contributes to the lung's defense against inhaled microorganisms. Additionally we are shipping Surfactant Associated Protein D Kits (22) and Surfactant Associated Protein D Proteins (11) and many more products for this protein.
Showing 10 out of 15 products:
Trimeric SP-D wildtype recognized larger LPS (show IRF6 Antibodies) inner core oligosaccharides with slightly enhanced affinity than smaller compounds suggesting the involvement of stabilizing secondary interactions.
rs2819096 in the surfactant protein D (SFTPD) gene was associated with a higher risk of COPD (show ARCN1 Antibodies) GOLD III + IV.
SP-D increases the formation of nuclear and membrane blebs. Inhibition of caspase-8 (show CASP8 Antibodies) confirms the effect of SP-D is unique to the caspase-8 (show CASP8 Antibodies) pathway.
Findings indicate serum pulmonary surfactant protein D (SP-D, SFTPD) level as a potential marker to estimate the efficacy of epidermal growth factor receptor (EGFR (show EGFR Antibodies))-tyrosine kinase (show TXK Antibodies) inhibitor (TKIs).
Patients with SP-D 11Thr/Thr (show TRH Antibodies) genotype were more susceptible to acute kidney injury (AKI). Compared with healthy controls, serum SP-D levels at day 1, 3 and 7 were significantly elevated in AKI patients.
This review intends to provide a current overview of the genetics, structure and extra-pulmonary functions of the surfactant collectin (show MBL2 Antibodies) proteins.
Meta-analysis found that serum SP-A/D detection might be useful for differential diagnosis and prediction of survival in patients with idiopathic pulmonary fibrosis.
The findings suggest that SP-D inhibits LPS (show IRF6 Antibodies)-stimulated production of interleukin-12p40 via the SIRPalpha/ROCK/ERK (show EPHB2 Antibodies) signaling pathway.
Efficient lipopolysaccharide recognition by SP-D requires multiple binding interactions utilizing the three major ligand-binding determinants in the SP-D binding pocket, with Ca-dependent binding of inner-core heptose accompanied by interaction of anhydro-Kdo (4,7-anhydro-3-deoxy-d-manno (show MAN2A1 Antibodies)-oct-2-ulosonic acid) with Arg343 and Asp325.
SP-D levels in bronchoalveolar lavage samples were significantly lower in severe asthma compared with healthy controls and mild asthma. Serum SP-D was significantly increased in severe asthma compared with healthy controls and mild asthma.
Elevation of SP-D is found in bronchoalveolar lavage fluid from inoculated lobes of calves infected with bovine adenovirus type 3.
The bSP (show KLK6 Antibodies)-D gene has 9 exons spanning about 10.5 kb on chromosome 28 at position q1.8. The 5'-upstream sequence has cis (show CISH Antibodies)-regulatory elements. It has 2 (show HAS2 Antibodies) polymorphisms in the carbohydrate recognition domain (242 Glu (show DCTN1 Antibodies)/Val & 268 Ala/Gly).
The authors demonstrated that the number and position of glycosylation sites determine viral susceptibility to the neutralizing activity of porcine SP-D.
Data show that interactions of surfactant protein D (pSP-D) with influenza A virus mediated by the N-linked carbohydrate moiety in pSP-D depend on the terminal sialic acids present on this moiety.
The presence of SP-D in endothelial cells which is NO-, PI(3 (show PI3 Antibodies))K/Akt (show AKT1 Antibodies)- and Erk (show MAPK1 Antibodies)-dependent is demonstrated. It suggests a protective role of SP-D in these cells.
The importance of SP-D in innate immunity is underlined by its expression at the potential ports of entry of pathogens: lung, tongue, intestinal tract, thymus, skin, gall bladder, lacrimal gland, esophagus, stomach, kidney, liver, prostate and spleen.
In triple KO mice, the HO-induced lung injury was associated with decreased surfactant protein (SP) A (show SFTPA1 Antibodies) and SPC (show SFTPC Antibodies) but not SPB and SPD expression.
Our study provides comprehensive information regarding spatial and temporal expression of collectins (SP-A (show SFTPA1 Antibodies), SP-D and MBL-A) and their cellular sources in murine testis. Positive regulation by testosterone and alteration in their level upon LPS (show TLR4 Antibodies) challenge are clues relevant to suggest their involvement in testicular immune privilege.
Our data may promote further studies on the morphological development of the aging lung and the role of SP-D in this process.
The experimentally induced alterations were more severe in the SP-D(-/-) than in the WT mice, particularly with respect to the surfactant-storing lamellar bodies which were sometimes extremely enlarged in SP-D(-/-) mice.
these results demonstrate SP-D plays protective roles by inhibiting apoptosis and modulating NF-kappaB-mediated inflammation in CLP-induced acute pancreatic injury .
SP-A (show SFTPA1 Antibodies)/D double knock-out mice showed increased susceptibility to urinary tract infection
Human and murine data together indicate that SP-A, SP-D and MBL are synthesized in early gestational tissues, and may contribute to regulation of immune response at the feto-maternal interface during pregnancy.
The presence of SP-A (show SFTPA1 Antibodies) and SP-D in the murine decidua is likely to play a protective role against intrauterine infection during pregnancy.
our results demonstrate that SFTPD deficiency affects female fertility, highlighting roles for SFTPD in ovarian and uterine physiology
the collectin (show MBL2 Antibodies) Surfactant Protein D is an essential component of host innate immunity to helminths
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. Mutations in this particular gene cause synpolydactyly.
, lung surfactant protein D
, pulmonary surfactant apoprotein
, pulmonary surfactant-associated protein D
, surfactant, pulmonary-associated protein D
, surfactant-associated protein, pulmonary 4
, homeo box 4I
, homeo box D13
, homeobox protein Hox-4I
, homeobox protein Hox-D13
, pulmonary surfactant protein D
, surfactant associated protein D