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binds carbohydrates\; may play a role in defense response in the lung [RGD, Feb 2006].. Additionally we are shipping Surfactant Associated Protein D Kits (17) and Surfactant Associated Protein D Proteins (11) and many more products for this protein.
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This review intends to provide a current overview of the genetics, structure and extra-pulmonary functions of the surfactant collectin (show MBL2 Antibodies) proteins.
Meta-analysis found that serum SP-A/D detection might be useful for differential diagnosis and prediction of survival in patients with idiopathic pulmonary fibrosis.
The findings suggest that SP-D inhibits LPS (show IRF6 Antibodies)-stimulated production of interleukin-12p40 via the SIRPalpha/ROCK/ERK (show EPHB2 Antibodies) signaling pathway.
Efficient lipopolysaccharide recognition by SP-D requires multiple binding interactions utilizing the three major ligand-binding determinants in the SP-D binding pocket, with Ca-dependent binding of inner-core heptose accompanied by interaction of anhydro-Kdo (4,7-anhydro-3-deoxy-d-manno (show MAN2A1 Antibodies)-oct-2-ulosonic acid) with Arg343 and Asp325.
SP-D levels in bronchoalveolar lavage samples were significantly lower in severe asthma compared with healthy controls and mild asthma. Serum SP-D was significantly increased in severe asthma compared with healthy controls and mild asthma.
SP-A (+186A/G) and SP-B (1580C/T) polymorphisms are strongly associated with the risk of respiratory distress syndrome (RDS (show PRPH2 Antibodies)) in preterm infants. Notably, reduced serum SP-A levels were correlated with a high risk of RDS (show PRPH2 Antibodies) and may serve as novel biomarkers for RDS (show PRPH2 Antibodies) detection and monitoring.
Obstructive sleep apnea-hypopnea syndrome pathogenesis was associated with changes in NF-kappaB (show NFKB1 Antibodies), HIF-1alpha (show HIF1A Antibodies), and SPD (show HOXD13 Antibodies) protein expression level
Surfactant protein D levels differed among idiopathic pulmonary fibrosis, pulmonary sarcoidosis and chronic pulmonary obstructive disease.
Elevated levels of SP-D are Associated with Idiopathic Pulmonary Fibrosis.
Data do not support that pSP-D levels influence or reflect the development of subclinical atherosclerosis. However, the data support that SP-D plays a role in the etiology of atherosclerotic disease development.
Our data may promote further studies on the morphological development of the aging lung and the role of SP-D in this process.
The experimentally induced alterations were more severe in the SP-D(-/-) than in the WT mice, particularly with respect to the surfactant-storing lamellar bodies which were sometimes extremely enlarged in SP-D(-/-) mice.
these results demonstrate SP-D plays protective roles by inhibiting apoptosis and modulating NF-kappaB-mediated inflammation in CLP-induced acute pancreatic injury .
SP-A (show SFTPA1 Antibodies)/D double knock-out mice showed increased susceptibility to urinary tract infection
Human and murine data together indicate that SP-A, SP-D and MBL are synthesized in early gestational tissues, and may contribute to regulation of immune response at the feto-maternal interface during pregnancy.
The presence of SP-A (show SFTPA1 Antibodies) and SP-D in the murine decidua is likely to play a protective role against intrauterine infection during pregnancy.
our results demonstrate that SFTPD deficiency affects female fertility, highlighting roles for SFTPD in ovarian and uterine physiology
the collectin (show MBL2 Antibodies) Surfactant Protein D is an essential component of host innate immunity to helminths
SP-D protects the ocular surface from S. aureus infection.
Estrogen positively regulates expression of SP-D in the mouse uterus. Progesterone, along with estrogen synergizes SP-D expression, however, when administered alone results in negative regulation.
Contributes to the lung's defense against inhaled microorganisms. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties.
, lung surfactant protein D
, pulmonary surfactant apoprotein
, pulmonary surfactant-associated protein D
, surfactant, pulmonary-associated protein D
, surfactant-associated protein, pulmonary 4
, pulmonary surfactant protein D
, surfactant associated protein D