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Synaptojanin 1 Proteins (SYNJ1)

SYNJ1 encodes a phosphoinositide phosphatase that regulates levels of membrane phosphatidylinositol-4,5-bisphosphate. Additionally we are shipping Synaptojanin 1 Antibodies (37) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat SYNJ1 SYNJ1 85238 Q62910
SYNJ1 8867 O43426
SYNJ1 104015  
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Top Synaptojanin 1 Proteins at antibodies-online.com

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

SYNJ1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for Synaptojanin 1 (SYNJ1) Interaction Partners

Fruit Fly (Drosophila melanogaster) Synaptojanin 1 (SYNJ1) interaction partners

  1. Mnb (show DYRK1A Proteins) is a synaptic kinase that promotes efficient synaptic vesicle recycling by Synj function at the neuromuscular junction.

  2. Findings imply that restoring the level of any one of these genes dap160/itsn1, synj/synj1, and nla/dscr1 (show RCAN1 Proteins) may reduce endocytic defects seen in DS.

  3. In the absence of synaptojanin or endophilin, vesicles undergo full fusion and re-formation.

Zebrafish Synaptojanin 1 (SYNJ1) interaction partners

  1. Synaptojanin 1 is required for endolysosomal trafficking of synaptic proteins in cone photoreceptor inner segments.

  2. This protein localized predominantly to cone photoreceptors. Using blastula stage transplantation experiments, study demonstrates that rods from mutants lacking SynJ1 develop normally and do not have the pronounced morphological defects detected in cones

  3. Synj1 is required for anchoring of ribbons, for vesicle maintenance, and for synaptic transmission at cone photoreceptor ribbon synapses.

  4. Synj1 is critical for retrieval of membrane in order to maintain the quantity, timing of fusion, and spontaneous release properties of synaptic vesicles at hair-cell ribbon synapses.

Human Synaptojanin 1 (SYNJ1) interaction partners

  1. Mutations in SYNJ1 gene do not play a major role in early-onset or familial PD in our population.

  2. This study demonstrated that SYNJ1 was significantly higher in Down syndrome and correlated with several measures of Abeta (show APP Proteins). SYNJ1 was higher in down syndrome with Alzheimer disease and significantly higher than SYNJ1 in sporadic Alzheimer disease.

  3. This is the third reported family with autosomal recessive, early-onset parkinsonism associated with the SYNJ1 p.Arg258Gln mutation. This work contributes to the definition of the genetic and clinical aspects of PARK20.

  4. the clinical progression of the Italian siblings with SYNJ1-related early-onset atypical parkinsonism seems to present a more severe progression in the early stages

  5. Our data suggest that the previously reported Arg258Gln mutation in SYNJ1 is not a frequent cause of Parkinson disease

  6. This review presented that SYNJ1 in recessive forms of juvenile parkinsonism.

  7. Findings suggest that SYNJ1 mutation is responsible for the early-onset Parkinsonism phenotype probably due to deficiencies in its phosphatase activity and consequent impairment of its synaptic functions.

  8. Results indicate that SYNJ1 gene is a compelling candidate for Parkinsonism; mutations in the functionally linked protein auxilin (show DNAJC6 Proteins) cause a similar early-onset phenotype, and other findings implicate endosomal dysfunctions in the pathogenesis.

  9. a novel mechanism by which reduction of a PI(4,5)P2-degrading enzyme, synj1, improves amyloid-induced neuropathology and behavior deficits through accelerating cellular Abeta (show APP Proteins) clearance.

  10. Trisomy for SYNJ1 in Down syndrome is functionally linked to the enlargement of early endosomes.

Cow (Bovine) Synaptojanin 1 (SYNJ1) interaction partners

Mouse (Murine) Synaptojanin 1 (SYNJ1) interaction partners

  1. a novel mechanism by which reduction of a PI(4,5)P2-degrading enzyme, synj1, improves amyloid-induced neuropathology and behavior deficits through accelerating cellular Abeta (show APP Proteins) clearance.

  2. These results implicate Pak5 (show PAK7 Proteins) in Pacsin1 (show PACSIN1 Proteins)- and Synaptojanin1-mediated synaptic vesicle trafficking.

  3. PI(4,5)P-to-PI4P conversion achieved by Synj1 at sites of high curvature may cooperate with dynamin (show DNM1 Proteins) to achieve membrane fission.

  4. synaptojanin 1 function is needed for the progression of recycling vesicles to the functional synaptic vesicle pool.

  5. PtdIns(4,5)P(2) dyshomeostasis caused by gene dosage imbalance for Synj1 may contribute to brain dysfunction and cognitive disabilities in down syndrome.

  6. Synaptojanin 1 functions in constitutive and triggered internalization of AMPA (show GRIA3 Proteins) receptors.

  7. Synaptojanin-1 is involved phosphatidylinositol metabolism in astrogliogenesis, but not in neurogenesis.

Synaptojanin 1 (SYNJ1) Protein Profile

Protein Summary

This gene encodes a phosphoinositide phosphatase that regulates levels of membrane phosphatidylinositol-4,5-bisphosphate. As such, expression of this enzyme may affect synaptic transmission and membrane trafficking. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with Synaptojanin 1 Proteins (SYNJ1)

  • synaptojanin (synj)
  • synaptojanin 1 (synj1)
  • synaptojanin 1 (SYNJ1)
  • synaptojanin 1 (LOC100228100)
  • synaptojanin 1 (Synj1)
  • A930006D20Rik protein
  • AA675315 protein
  • CG6562 protein
  • Dmel\\CG6562 protein
  • fb02f11 protein
  • fi15a11 protein
  • INPP5G protein
  • IPP protein
  • mKIAA0910 protein
  • nrc protein
  • Synj protein
  • SYNJ1 protein
  • wu:fb02f11 protein
  • wu:fi15a11 protein

Protein level used designations for Synaptojanin 1 Proteins (SYNJ1)

CG6562-PA , CG6562-PB , CG6562-PC , synj-PA , synj-PB , synj-PC , no optokinetic response c , synaptojanin-1 , synaptojanin 1 , synaptojanin 1, isoform 1 , synaptojanin-1-like , synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1 , synaptic inositol-1,4,5-trisphosphate 5-phosphatase 1 , inositol 5'-phosphatase (synaptojanin 1) , synaptojanin-1, polyphosphoinositide phosphatase , p150

GENE ID SPECIES
37517 Drosophila melanogaster
337236 Danio rerio
473959 Pan troglodytes
100052605 Equus caballus
100137543 Papio anubis
100228100 Taeniopygia guttata
100395303 Callithrix jacchus
100487517 Xenopus (Silurana) tropicalis
100567389 Anolis carolinensis
85238 Rattus norvegicus
418498 Gallus gallus
8867 Homo sapiens
478403 Canis lupus familiaris
282087 Bos taurus
100328807 Oryctolagus cuniculus
104015 Mus musculus
100525664 Sus scrofa
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