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Synaptotagmin II Proteins (SYT2)

Synaptotagmins, like SYT2, are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis (Hilbush and Morgan, 1994 [PubMed 8058779]).[supplied by OMIM, Mar 2008].. Additionally we are shipping Synaptotagmin II Antibodies (74) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SYT2 127833 Q8N9I0
SYT2 20980 P46097
SYT2 24805 P29101
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Top Synaptotagmin II Proteins at

Showing 5 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 Days
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days

SYT2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, , ,
Mouse (Murine)
Rat (Rattus)

More Proteins for Synaptotagmin II (SYT2) Interaction Partners

Zebrafish Synaptotagmin II (SYT2) interaction partners

  1. knockdown of synaptotagmin 2 (syt2) reduces synchronous release, whereas knockdown of synaptotagmin 7 (syt7 (show SYT7 Proteins)) reduces the asynchronous component of release.

Human Synaptotagmin II (SYT2) interaction partners

  1. SYT2 mutations cause a novel complex presynaptic congenital myasthenic syndrome characterized by motor neuropathy causing lower limb wasting and foot deformities, reflex potentiation following exercise and a prolonged period of posttetanic potentiation

  2. Synaptotagmin 2 mutations cause an autosomal-dominant form of lambert-eaton myasthenic syndrome and nonprogressive motor neuropathy.

  3. Human SytII is not an effective receptor for Botulinum neurotoxin D-C.

  4. synaptotagmin-II is not a high affinity receptor for BoNT/B and G due to a phenylalanine to leucine mutation in its luminal domain present only in humans and chimpanzees

  5. role for synaptotagmin II as calcium-sensor during phagocytosis and secretion in neutrophils

  6. both synaptotagmins I and II can interact with the syntaxin/synaptosomal-associated protein of 25 kDa (SNAP-25 (show SNAP25 Proteins)) dimer

  7. WNK1 (show WNK1 Proteins) selectively binds to and phosphorylates synaptotagmin 2 (Syt2) within its calcium binding C2 domains. Endogenous WNK1 (show WNK1 Proteins) and Syt2 coimmunoprecipitate and colocalize on a subset of secretory granules in INS-1 (show FOXM1 Proteins) cells.

  8. A recombinant fragment from the luminal domain of the human receptor protein syt (show SS18 Proteins) II can bind specifically to botulinum neurotoxin B and its Hc domain.

  9. Mutation of overexpressed Syt2 transgene leaves intrinsic calcium sensitivity of vesicles intact while it destabilizes the readily releasable pool of vesicles and loosens the tight coupling between calcium influx and release.

Mouse (Murine) Synaptotagmin II (SYT2) interaction partners

  1. The 2.3-A structure of a ternary complex of botulinum neurotoxin type B bound to both its protein receptor synaptotagmin II and its ganglioside receptor GD1a, is reported.

  2. Synaptotagmins 1 and 2 as mediators of rapid exocytosis at nerve terminals: the dyad hypothesis

  3. Syt2 make it an excellent marker for analyzing the development and plasticity of perisomatic inhibitory innervations onto both excitatory and inhibitory neurons in the visual cortex.

  4. Syt2 increases the dynamic range of synapses by driving release with a high Ca(2 (show CA2 Proteins))+ cooperativity, as well as by suppressing a remaining, near-linear Ca(2 (show CA2 Proteins))+ sensor.

  5. Transient expression of Syt2 is no longer detected in cochlear inner hair cells (IHCs) after the onset of hearing, indicating that the most common calcium-sensors in central nervous system synapses are not involved in mature IHC ribbon synapse.

  6. SYT2 was a negative regulator of chemotaxis

  7. The readily releasable pool was rescued by Syt2 overexpression. The kinetics of fusion was slightly slower than in cells expressing Syt1. Syt2 has a lower Ca2+ affinity for phospholipid binding than Syt1 because of a difference in the C2A domain.

  8. Data suggest that synaptotagmins 1 and 2 perform equivalent functions in the Ca2 (show CA2 Proteins)+ triggering of action potential-induced neurotransmitter release and in the restriction of spontaneous release.

  9. Synaptotagmin-2 is an essential synaptotagmin isoform that functions in concert with other synaptotagmins in the calcium-ion triggering of neurotransmitter release.

  10. The cell-, temporal-, and species-specific expression of synaptotagmin isoforms suggests that each may have distinct functions in neurotransmitter release

Synaptotagmin II (SYT2) Protein Profile

Protein Summary

Synaptotagmins, like SYT2, are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis (Hilbush and Morgan, 1994

Gene names and symbols associated with Synaptotagmin II Proteins (SYT2)

  • synaptotagmin-2-like (LOC100146749)
  • synaptotagmin IIa (syt2a)
  • synaptotagmin II (syt2)
  • synaptotagmin II (SYT2)
  • synaptotagmin II (Syt2)
  • synaptotagmin-like 2 (SYTL2)
  • mKIAA4194 protein
  • R74640 protein
  • RATSYNII protein
  • si:ch211-236j4.1 protein
  • SYNII protein
  • SytII protein

Protein level used designations for Synaptotagmin II Proteins (SYT2)

synaptotagmin II , synaptotagmin 2 , synaptotagmin-2 , sytII

100146749 Equus caballus
567877 Danio rerio
100158469 Xenopus (Silurana) tropicalis
100511582 Sus scrofa
100594116 Nomascus leucogenys
127833 Homo sapiens
20980 Mus musculus
24805 Rattus norvegicus
100300626 Bos taurus
396327 Gallus gallus
485154 Canis lupus familiaris
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