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The protein encoded by SDCBP was initially identified as a molecule linking syndecan-mediated signaling to the cytoskeleton. Additionally we are shipping SDCBP Antibodies (89) and SDCBP Kits (5) and many more products for this protein.
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Human SDCBP Protein expressed in Escherichia coli (E. coli) - ABIN667285
Sarkar, Boukerche, Su, Fisher: mda-9/Syntenin: more than just a simple adapter protein when it comes to cancer metastasis. in Cancer research 2008
Show all 2 references for ABIN667285
Syntenin-1 negatively regulates the intestinal immunoglobulin production and has a function to maintain the intestinal homeostasis in vivo.
ALCAM (show ALCAM Proteins) stably interacts with actin by binding to syntenin-1 and ezrin (show EZR Proteins).
Angiopoietin-2 (show ANGPT2 Proteins) secretion by endothelial cell exosomes: regulation by the phosphatidylinositol 3-kinase (PI3K)/Akt (show AKT1 Proteins)/endothelial nitric oxide synthase (eNOS (show NOS3 Proteins)) and syndecan-4 (show SDC4 Proteins)/syntenin pathways.
MDA-9/syntenin may play a prominent role during normal mouse development in the context of cell proliferation as well as differentiation through modulating multiple signaling pathways as a crucial adaptor protein.
Complex of Unc51.1 (show ULK1 Proteins)/SynGAP1 (show SYNGAP1 Proteins)/Syntenin governs axon formation via Ras-like GTPase signaling and through regulation of the Rab5 (show RAB5A Proteins)-mediated endocytic pathways within developing axons
Syntenin-1 may function as a scaffolding protein coupling CD6 (show CD6 Proteins) and other lymphocyte receptors to cytoskeleton and/or signaling effectors during immunologic synapse maturation
syntenin plays a role in the migration of oligodendroglial precursors, and we suggest that NG2 (show Vcan Proteins)-syntenin-1 interactions contribute to this
In summary, the study identifies miR (show MLXIP Proteins)-216b as a regulator of SDCBP expression in breast cancer which can potentially be targeted for developing newer therapies for the effective treatment of this killer disease.
Data show that patients with high MDA-9/Syntenin and high Slug (show SNAI2 Proteins) expressions were associated with poor overall survival compared to those with low expression in lung adenocarcinomas.
Data suggest that syntenin/SDCBP PDZ domains 1 and 2 recognize a broad range of peptide ligands with preferences for nectin-1 (show PVRL1 Proteins), hydrophobic amino acid motifs, and cryptic internal ligands/peptide fragments.
these findings demonstrate that syntenin may act as an important positive regulator of TGF-b signaling by regulating caveolin-1 (show CAV1 Proteins)-mediated internalization of TbRI; thus, providing a novel function for syntenin that is linked to cancer progression.
To predict mda-9's association with extracellular matrix organization.
MDA-9, co-expressed with GRP78 (show HSPA5 Proteins), as a melanoma protein associated with lymph node metastasis. Investigating how MDA-9 and GRP78 (show HSPA5 Proteins) interact to contribute to melanoma metastasis and disease progression could reveal new potential avenues of targeted therapy
Syntenin-ALIX (show PDCD6IP Proteins) exosome biogenesis and budding into multivesicular bodies are controlled by ARF6 (show ARF6 Proteins) and PLD2 (show PLD2 Proteins).
High MDA-9 expresison is associated with glioma.
Our findings indicate that MDA-9/Syntenin might provide an attractive target for developing detection, monitoring, and therapeutic strategies for managing Urothelial cell carcinoma .
findings show that epiboly relies on the molecular networking of syntenin with syndecan (show SDC1 Proteins) heparan sulphate proteoglycans, which act as co-receptors for adhesion molecules and growth factors
The protein encoded by this gene was initially identified as a molecule linking syndecan-mediated signaling to the cytoskeleton. The syntenin protein contains tandemly repeated PDZ domains that bind the cytoplasmic, C-terminal domains of a variety of transmembrane proteins. This protein may also affect cytoskeletal-membrane organization, cell adhesion, protein trafficking, and the activation of transcription factors. The protein is primarily localized to membrane-associated adherens junctions and focal adhesions but is also found at the endoplasmic reticulum and nucleus. Alternative splicing results in multiple transcript variants encoding different isoforms.
, scaffold protein Pbp1
, syndecan interacting protein
, syndecan-binding protein 1
, melanoma differentiation associated protein-9
, melanoma differentiation-associated protein 9
, pro-TGF-alpha cytoplasmic domain-interacting protein 18