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anti-Syntaxin Binding Protein 5 (Tomosyn) (STXBP5) Antibodies

Syntaxin 1 is a component of the 7S and 20S SNARE complexes which are involved in docking and fusion of synaptic vesicles with the presynaptic plasma membrane. Additionally we are shipping STXBP5 Proteins (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
STXBP5 134957 Q5T5C0
STXBP5 78808  
STXBP5 81022 Q9WU70
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Top anti-STXBP5 Antibodies at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Mouse Un-conjugated BI, IF, WB Western blot analysis of tomosyn on a rat cerebrum lysate. Lane 1: 1:250, Lane 2: 1:500, Lane 3: 1:1000 dilution of the anti-tomosyn antibody. 50 μg Log in to see 5 to 6 Days
$205.42
Details
Human Rabbit Un-conjugated ICC, WB dilution: 1 : 1000, sample: crude synaptosomal fraction of rat brain (P2) Immunofluorescence labeling of PFA fixed rat hippocampus neurons with anti-tomosyn (dilution 1 : 500; red) and mouse anti-MAP 2, (cat. no. 188 011, dilution 1 : 500; green). Nuclei have been visualized by DAPI staining (blue). 50 μg Log in to see 5 to 6 Days
$398.48
Details
Human Mouse Un-conjugated ELISA, WB Western Blot detection against Immunogen (37 KDa) . 50 μL Log in to see 9 Days
$298.57
Details
Human Rabbit Un-conjugated WB   0.1 mL Log in to see 6 to 9 Days
$452.81
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB   100 μL Log in to see 3 to 7 Days
$269.50
Details

STXBP5 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Human
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Mouse (Murine)
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Rat (Rattus)
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Top referenced anti-STXBP5 Antibodies

  1. Human Monoclonal STXBP5 Primary Antibody for BI, IF - ABIN968460 : Fujita, Shirataki, Sakisaka, Asakura, Ohya, Kotani, Yokoyama, Nishioka, Matsuura, Mizoguchi, Scheller, Takai: Tomosyn: a syntaxin-1-binding protein that forms a novel complex in the neurotransmitter release process. in Neuron 1998 (PubMed)
    Show all 2 references for ABIN968460

  2. Human Polyclonal STXBP5 Primary Antibody for ICC, WB - ABIN1742382 : Burgalossi, Jung, Meyer, Jockusch, Jahn, Taschenberger, OConnor, Nishiki, Takahashi, Brose, Rhee: SNARE protein recycling by αSNAP and βSNAP supports synaptic vesicle priming. in Neuron 2010 (PubMed)

More Antibodies against STXBP5 Interaction Partners

Human Syntaxin Binding Protein 5 (Tomosyn) (STXBP5) interaction partners

  1. Genetic variations in STXBP5 and CLEC4M (show CLEC4M Antibodies) are associated with VWF (show VWF Antibodies) level variation in type 1, but not in type 2 von Willebrand disease.

  2. STXBP5 is required for normal arterial hemostasis, due to its contributions to platelet granule cargo packaging and secretion

  3. STXBP5 inhibits endothelial exocytosis and promotes platelet secretion

  4. Identify 3 loci associated with circulating tPA (show PLAT Antibodies) levels, the PLAT (show PLAT Antibodies) region, STXBP5, and STX2 (show STX2 Antibodies). Functional studies implicate a novel role for STXBP5 and STX2 (show STX2 Antibodies) in regulating tPA (show PLAT Antibodies) release.

  5. Genetic variation in STXBP5 is associated with bleeding phenotype in female type 1 von Willebrand Disease patients.

  6. Genetic variation in STXBP5 gene is associated with venous thrombosis.

  7. multiple domains outside the R-SNARE (show YKT6 Antibodies) of tomosyn are critical to the efficacy of inhibition by tomosyn on exocytotic secretion

  8. Genetic variability in STXBP5 and STX2 (show STX2 Antibodies) affects both VWF (show VWF Antibodies) concentration and activity in young individuals with premature arterial thrombosis.

Mouse (Murine) Syntaxin Binding Protein 5 (Tomosyn) (STXBP5) interaction partners

  1. PIASgamma-dependent modification of tomosyn-1 with SUMO-2 (show SUMO2 Antibodies)/3 presents a novel mechanism to adapt secretory strength to the dynamic synaptic environment.

  2. STXBP5 is required for normal arterial hemostasis, due to its contributions to platelet granule cargo packaging and secretion

  3. STXBP5 inhibits endothelial exocytosis and promotes platelet secretion

  4. regulates SNARE (show VTI1B Antibodies) complex formation and synaptic vesicle fusion. (review)

  5. Interacts with SNAP23 (show SNAP23 Antibodies) and Syntaxin4 (show STX4 Antibodies) and plays a role in Insulin (show INS Antibodies)-stimulated GLUT4 (show SLC2A4 Antibodies) translocacion.

  6. The interaction between syntaxin4 (show STX4 Antibodies) and Munc18c (show STXBP3 Antibodies) in adipocytes results in enhancement of insulin (show INS Antibodies)-stimulated GLUT4 (show SLC2A4 Antibodies) externalization.

  7. In the pancreatic beta-cell, tomosyn negatively regulates insulin (show INS Antibodies) exocytosis.

  8. Tomosyn-1 is involved in a post-docking event that prepares secretory granules for fusion and is necessary to sustain exocytosis of pancreatic beta-cells in response to insulin (show INS Antibodies) secretagogues.

  9. Tomosyn inhibits neurotransmitter release by catalyzing oligomerization of the SNARE (show VTI1B Antibodies) complex through the N-terminal WD-40 repeat domain in addition to the inhibitory activity of the C-terminal (VAMP (show VAMP Antibodies))-like domain.

STXBP5 Antigen Profile

Protein Summary

Syntaxin 1 is a component of the 7S and 20S SNARE complexes which are involved in docking and fusion of synaptic vesicles with the presynaptic plasma membrane. This gene encodes a syntaxin 1 binding protein. In rat, a similar protein dissociates syntaxin 1 from the Munc18/n-Sec1/rbSec1 complex to form a 10S complex, an intermediate which can be converted to the 7S SNARE complex. Thus this protein is thought to be involved in neurotransmitter release by stimulating SNARE complex formation. Alternatively spliced transcript variants encoding different isoforms have been identified.

Gene names and symbols associated with STXBP5

  • syntaxin binding protein 5 (tomosyn) (STXBP5) antibody
  • syntaxin binding protein 5 (tomosyn) (Stxbp5) antibody
  • 0710001E20Rik antibody
  • 4930565N16Rik antibody
  • AW742610 antibody
  • LGL3 antibody
  • LLGL3 antibody
  • mKIAA1006 antibody
  • Nbla04300 antibody

Protein level used designations for STXBP5

lethal(2) giant larvae protein homolog 3 , putative protein product of Nbla04300 , syntaxin-binding protein 5 , tomosyn , tomosyn-1 , tomosyn 1

GENE ID SPECIES
134957 Homo sapiens
78808 Mus musculus
81022 Rattus norvegicus
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