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T-Box 5 Proteins (TBX5)

TBX5 is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. Additionally we are shipping T-Box 5 Antibodies (67) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TBX5 6910 Q99593
TBX5 21388 P70326
TBX5 304514 Q5I2P1
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Top T-Box 5 Proteins at

Showing 5 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days

TBX5 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
Mouse (Murine)

Rat (Rattus)

More Proteins for T-Box 5 (TBX5) Interaction Partners

Xenopus laevis T-Box 5 (TBX5) interaction partners

  1. we show TBX5 and TBX20 (show TBX20 Proteins) can physically interact and map the interaction domains, and we show a cellular interaction for the two proteins in cardiac development

Human T-Box 5 (TBX5) interaction partners

  1. The crystal structure of cardiac TBX5 protein includes the N-terminal and DNA binding domains, which mediate intermolecular interactions.

  2. Exome analysis revealed the splice mutation (c.148-1G>C) in TBX5 gene showing that haploinsufficiency of TBX5 protein caused the symptoms of the patients with Holt-Oram syndrome.

  3. defines a TBX5-nucleosome remodeling and deacetylase interaction essential to cardiac development and the evolution of the mammalian heart

  4. Data show that the combination of GATA binding protein 4 (Gata4 (show GATA4 Proteins)), T-box transcription factor 5 (Tbx5) and BRG1-associated factor 60C (show SMARCD3 Proteins) protein (Baf60c (show SMARCD3 Proteins)) is sufficient for inducing adipose tissue-derived mesenchymal stem cells (ADMSCs) to form cardiomyocytes.

  5. All Holt-Oram syndrome patients in this study showed cardiac septal anomalies. Half of them showed TBX5 gene mutations.

  6. a novel heterozygous TBX5 mutation, p.A143T, was identified in a patient with sporadic dilated cardiomyopathy.

  7. TBX5 mutation is involved in the development of cardiac conduction disorders.

  8. Two heterozygous mutations in TBX5 were discovered in screening a series of 94 patients with Tetralogy of Fallot.

  9. A novel TBX5 mutation, p.S154A, was identified in a family with familial dilated cardiomyopathy.The mutation was associated with significantly decreased TBX5 transcriptional activity.

  10. a novel mutation of TBX5 gene in Holt-Oram Syndrome

Mouse (Murine) T-Box 5 (TBX5) interaction partners

  1. Data show that three transcriptional factors Gata4 (show GATA4 Proteins), Mef2c (show MEF2C Proteins), and Tbx5 (abbreviated as GMT (show GAMT Proteins)) significantly improved murine embryonic stem cells (ESCs (show NR2E3 Proteins)) differentiated into cardiomyocytes.

  2. defines a TBX5-nucleosome remodeling and deacetylase interaction essential to cardiac development and the evolution of the mammalian heart

  3. Study reports extensive and complex interdependent genomic occupancy of TBX5, NKX2-5 (show NKX2-5 Proteins), and the zinc finger TF GATA4 (show GATA4 Proteins) coordinately controlling cardiac gene expression, differentiation, and morphogenesis.

  4. Tbx5 and Osr1 (show OSR1 Proteins) interact to regulate posterior second heart field cell cycle progression for cardiac septation.

  5. Haploinsufficiency of Tbx5 and trisomy affects alignment of the aorta and this effect may stem from deviations from normal left-right patterning in the heart; study unveiled a previously unknown interaction between the Tbx5 gene and trisomy, suggesting a connection between Tbx5 and trisomic genes important during heart development.

  6. These findings elucidate mechanisms regulating the commitment of mesodermal cells in the early embryo and identify the Tbx5 cardiac transcriptome.

  7. these data suggest that the molecular pathogenesis of ventricular septal defectss in Moz germline mutant mice is due to loss of MOZ-dependant activation of mesodermal Tbx1 (show TBX1 Proteins) and Tbx5 expression.

  8. our findings reveal a novel mechanism for regulation of SCFFbox25-dependent Nkx2-5 (show NKX2-5 Proteins) and Tbx5 ubiquitination in cardiac development and provide a new insight into the regulatory mechanism of Nkx2-5 (show NKX2-5 Proteins) and Tbx5 transcriptional activity.

  9. Our findings implicate Foxf (show FOXF1 Proteins) genes in atrioventricular septation, describe the molecular underpinnings of the genetic interaction between Hedgehog (show SHH Proteins) signaling and Tbx5, and establish a molecular model for the selection of the SHF (show SHF Proteins) gene regulatory network

  10. Disruption of myocardial Gata4 (show GATA4 Proteins) and Tbx5 results in defects in cardiomyocyte proliferation and atrioventricular septation.

Zebrafish T-Box 5 (TBX5) interaction partners

  1. a mesodermal Fgf24 convergence cue controlled by Tbx5a underlies this asymmetric convergent motility.

  2. Results show that cul4a (show CUL4A Proteins) but not cul4b (show CUL4B Proteins) is required for the expression of tbx5a, an essential transcription factor in heart and limb development.

  3. The tbx5 genes have essential roles in the establishment of cardiac laterality, dorsoventral retina axis organization and pectoral fin development.

  4. tbx5 knockdown causes a pseudo GH deficiency in zebrafish during early embryonic stages, and supplementation of exogenous GH can partially restore dysmorphogenesis, apoptosis, cell growth inhibition, and abnormal cardiomyogenesis

  5. tbx5 deficiency evoked apoptosis, distributed on multiple organs corresponding to dysmorphogenesis with the shortage of promising maturation, in tbx5 knockdown zebrafish embryos

  6. data demonstrate that elevated glucose alone induces cardiac defects in zebrafish embryos by altering the expression pattern of tbx5, tbx20 (show TBX20 Proteins), and has2 (show HAS2 Proteins) in the heart

  7. Tbx5a confers anterior lateral plate mesodermal cells the competence to respond to Bmp signals and initiate proepicardial organ development.

  8. Pdlim7 (show PDLIM7 Proteins)/Tbx5 interactions affect the expression of Tbx5 target genes nppa (show NPPA Proteins) and tbx2b at the atrio-ventricular boundary, and their domains of misexpression directly correlate with the identified valve defects.

  9. The heartstrings mutation in zebrafish causes heart/fin Tbx5 deficiency syndrome.

  10. overexpression of hrT (show TBX20 Proteins) causes a significant downregulation of tbx5, indicating that one key role of hrT (show TBX20 Proteins) is to regulate the levels of tbx5

T-Box 5 (TBX5) Protein Profile

Protein Summary

This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is closely linked to related family member T-box 3 (ulnar mammary syndrome) on human chromosome 12. The encoded protein may play a role in heart development and specification of limb identity. Mutations in this gene have been associated with Holt-Oram syndrome, a developmental disorder affecting the heart and upper limbs. Several transcript variants encoding different isoforms have been described for this gene.

Gene names and symbols associated with T-Box 5 Proteins (TBX5)

  • T-box 5 (TBX5)
  • T-box 5 (tbx5)
  • T-box 5 (LOC100356836)
  • T-box 5 (tbx5-b)
  • T-box 5 (Tbx5)
  • T-box 5a (tbx5a)
  • HOS protein
  • tbx-5 protein
  • tbx5 protein
  • tbx5.1 protein
  • xtbx-5 protein
  • xtbx5 protein
  • zf-tbx5 protein
  • zTbx5 protein

Protein level used designations for T-Box 5 Proteins (TBX5)

T-box 5 , T-box protein 5 , T-box transcription factor 5 , T-box transcription factor TBX5 , T-box transcription factor TBX5-like , t-box transcription factor TBX5-like , T-box gene 5 , T-box gene 5.1 , T-box transcription factor TBX5-A , etID310031.5 , heartstrings , hst , zftbx5a

452276 Pan troglodytes
619589 Xenopus (Silurana) tropicalis
713550 Macaca mulatta
100018880 Monodelphis domestica
100356836 Oryctolagus cuniculus
100397050 Callithrix jacchus
100451005 Pongo abelii
100478001 Ailuropoda melanoleuca
100529166 Oryzias latipes
373738 Xenopus laevis
373988 Gallus gallus
6910 Homo sapiens
491447 Canis lupus familiaris
21388 Mus musculus
304514 Rattus norvegicus
532970 Bos taurus
30071 Danio rerio
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