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TBX15 belongs to the T-box family of genes, which encode a phylogenetically conserved family of transcription factors that regulate a variety of developmental processes. Additionally we are shipping T-Box 15 Antibodies (36) and many more products for this protein.
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first genome-wide scan for selection in Inuit from Greenland. A region, with a deeply divergent haplotype that is closely related to the sequence in the Denisovan genome contains two genes, WARS2 (show WARS2 Proteins) and TBX15. our study suggests a complex multi-factorial regulation of TBX15 and WARS2 (show WARS2 Proteins). We show that the introgressed region is associated with regional changes in methylation and expression levels
TBX15 and NF-kappaB (show NFKB1 Proteins) found in this study may be important to understand cancer and development processes.
The results indicate the antiapoptotic role of TBX15 in cancer cells, suggesting a contribution of TBX15 in carcinogenesis.
Two traits of ear pinna anatomic variation are associated with SNPs in a region overlapping the TBX15 gene.
Genes within recently identified loci associated with waist-hip ratio (WHR) exhibit fat depot-specific mRNA expression, which correlates with obesity-related traits. Adipose tissue (AT) mRNA expression of 6 genes (TBX15/WARS2 (show WARS2 Proteins), STAB1, PIGC (show PIGC Proteins), ZNRF3 (show ZNRF3 Proteins), GRB14 (show GRB14 Proteins)
We identified homozygosity for a novel nonsense mutation (c.841C>T) in TBX15 predicted to cause a premature stop (p.Arg281*) with truncation of the protein.
TBX15 might be involved in the pathophysiology of placental diseases.
TBX15 mutations cause craniofacial dysmorphism, hypoplasia of scapula and pelvis, and short stature in Cousin syndrome.
Tbx15 is one of a limited number of transcription factors to be identified with a critical role in regulating glycolytic fibre identity and muscle metabolism.
Tbx15 may be essential for the development of the adipogenic and thermogenic programs in adipocytes/adipomyocytes capable of developing brown adipocyte features
Study establish that expression of Tbx15, Prrx1 (show PRRX1 Proteins), and Pax1 (show PAX1 Proteins), among other genes involved in the specification and development of select pelvic structures, is altered in our compound mutants.
Mesodermal developmental gene Tbx15 impairs adipocyte differentiation and mitochondrial respiration.
phenotypes result from competition between the ectopically expressed Tbx6 (show TBX6 Proteins) and the endogenously expressed Tbx18 (show TBX18 Proteins) and Tbx15 at the binding sites of target genes
Tbx15 has a role in mouse coat dorsoventral patterning
Tbx15 plays an important role in the development of the skeleton of the limb, vertebral column and head by controlling the number of mesenchymal precursor cells and chondrocytes
Tbx15 and Gli3 (show GLI3 Proteins) appear to have synergistic functions in formation of the scapular blade
areas of tbx15 expression are in the anterior somitic mesoderm, in periocular mesenchyme and in the pectoral fin mesenchyme throughout larval development
This gene belongs to the T-box family of genes, which encode a phylogenetically conserved family of transcription factors that regulate a variety of developmental processes. All these genes contain a common T-box DNA-binding domain. Mutations in this gene are associated with Cousin syndrome.
, T-box transcription factor TBX15
, T-box transcription factor TBX15-like
, t-box transcription factor TBX15-like
, T-box 14
, T-box protein 14
, T-box protein 15
, T-box transcription factor TBX14
, droopy ear