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The protein encoded by TIAL1 is a member of a family of RNA-binding proteins, has three RNA recognition motifs (RRMs), and binds adenine and uridine-rich elements in mRNA and pre-mRNAs of a wide range of genes. Additionally we are shipping TIA1 Cytotoxic Granule-Associated RNA Binding Protein-Like 1 Antibodies (26) and many more products for this protein.
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Data suggest that TPD52 (tumor protein D52) and a TPD52 fragment (residues 78-280) along with TIA-1 (show TIA1 Proteins) (T-cell intracellular antigen-1) and TIAR (TIA-1-related protein) contribute to mRNA stability as cis (show CISH Proteins)-acting and trans-acting factors; 3prime-untranslated regions of TPD52, TPD53, and TPD54 regulate expression of their respective genes in a post-transcriptional manner by altering mRNA stability.
results suggest that TIA-1 and TIAR are two new host factors that interact with 5-UTR of EV71 genome and positively regulate viral replication
TIAL1 inhibition of the exon 8 exclusion led to a decrease in SIRT1 (show SIRT1 Proteins)-Exon8 mRNA levels.
TIA proteins can function as long-term regulators of the ACTB (show ACTB Proteins) mRNA metabolism in mouse and human cells.
A role for TIAR is identified in T-cells for control of translational specificity.
findings demonstrate that TIAR recognition motif 2 (RRM2 (show RRM2 Proteins)), together with its C-terminal extension, is the major contributor for the high-affinity (nM) interactions of TIAR with target RNA sequences
TIA1 (show TIA1 Proteins) and TIAR proteins are intron-associated positive regulators of SMN2 (show SMN1 Proteins) exon 7 splicing.
Severe hypoxia caused co-aggregation of TIAR/TIA-1 and these proteins suppressed HIF-1alpha (show HIF1A Proteins) expression.
Data show that TIA1 (show TIA1 Proteins) and TIAL1 bind at the same positions on human RNAs, and are consistent with a model where TIA proteins shorten the time available for definition of an alternative exon by enhancing recognition of the preceding 5' splice site.
Data show that apoptotic (TIAR and TIA-1 (show TIA1 Proteins)) marker expression in thyroid tissues from adolescents with immune thyroid diseases is higher than in non-immune thyroid diseases.
Silencing of TIAR in chronic myeloid leukemia cells strongly elevated BRCA1.
Either TIA1 (show TIA1 Proteins) or TIAR inactivation broadly alter normal development-associated signalling pathways in murine embryonic fibroblasts.
study reports the importance of the tightly balanced expression of the RNA-binding protein TIAR for normal embryonic development, thereby emphasizing the role of post-transcriptional regulations in early embryonic programming
prion (show PRNP Proteins)-like aggregation of TIA-1 (show TIA1 Proteins) regulates stress granules formation downstream of eIF2alpha (show EIF2A Proteins) phosphorylation in response to stress
in addition to transcriptional regulation, another mechanism by which apigenin prevents COX-2 expression is through mediating TIAR suppression of translatino
TIAR regulates the relative expression of TIA-1 (show TIA1 Proteins) isoforms.
TIA1 (show TIA1 Proteins) and TIAL1 regulate the alternate splicing of lysyl hydroxylase 2 (show PLOD2 Proteins)
The intronic splicing enhancer of minute virus of mice binds the cellular RNA-processing proteins TIA-1 (show TIA1 Proteins) and TIAR, which enhance usage of the nonconsensus donor.
SOD1 (show SOD1 Proteins) sequesters Hu antigen R (HuR (show ELAVL1 Proteins)) and TIA-1-related protein (TIAR) and has a role in impaired post-transcriptional regulation of vascular endothelial growth factor
The protein encoded by this gene is a member of a family of RNA-binding proteins, has three RNA recognition motifs (RRMs), and binds adenine and uridine-rich elements in mRNA and pre-mRNAs of a wide range of genes. It regulates various activities including translational control, splicing and apoptosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The different isoforms have been show to function differently with respect to post-transcriptional silencing.
TIA1 cytotoxic granule-associated RNA binding protein-like 1
, nucleolysin TIAR
, T-cluster binding protein
, TIA-1-related nucleolysin
, aging-associated gene 7 protein
, TIA-1-related protein
, Tial1 cytotoxic granule-associated RNA binding protein-like 1
, Tial1 cytotoxic granule-associated RNA-binding protein-like 1
, RNA binding protein TIAR (TIA-1 related)
, Tial 1 cytotoxic granule-associated RNA- binding protein-like 1