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anti-TIMELESS Interacting Protein (TIPIN) Antibodies

Required for normal progression of S-phase. Additionally we are shipping TIPIN Kits (12) and TIPIN Proteins (10) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
TIPIN 100359731  
TIPIN 54962 Q9BVW5
TIPIN 66131 Q91WA1
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Top anti-TIPIN Antibodies at antibodies-online.com

Showing 10 out of 68 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-TIPIN Antibody Titration: 0.2-1 ug/mlPositive Control: Human heart 100 μL Log in to see 2 to 3 Days
$289.00
Details
Chicken Rabbit Un-conjugated WB WB Suggested Anti-TIPIN Antibody Titration: 5.0ug/mlPositive Control: Jurkat cell lysate 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Rabbit Un-conjugated WB TIPIN Antibody (N-term) (ABIN1881887) western blot analysis in Hela cell line lysates (35 µg/lane). This demonstrates the TIPIN antibody detected the TIPIN protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, WB   0.1 mg Log in to see 6 to 8 Days
$456.50
Details
Human Rabbit Un-conjugated WB 100 μg Log in to see 8 to 10 Days
$493.17
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated ELISA, WB 100 μg Log in to see 2 to 3 Days
$343.75
Details
Human Rabbit Un-conjugated ELISA, WB 50 μg Log in to see 2 to 3 Days
$433.13
Details
Human Mouse Un-conjugated WB Western Blot analysis of TIPIN expression in transfected 293T cell line by TIPIN monoclonal antibody (M01), clone 1G11. Lane 1: TIPIN transfected lysate(34.496 KDa). Lane 2: Non-transfected lysate. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Rabbit Alkaline Phosphatase (AP) ELISA, WB   200 μL Log in to see 8 to 10 Days
$969.83
Details

TIPIN Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Rat (Rattus)


Human , , ,
,
,
, , , , ,
Mouse (Murine)



Top referenced anti-TIPIN Antibodies

  1. Human Polyclonal TIPIN Primary Antibody for WB - ABIN1881887 : Kemp, Akan, Yilmaz, Grillo, Smith-Roe, Kang, Cordeiro-Stone, Kaufmann, Abraham, Sancar, Unsal-Kaçmaz: Tipin-replication protein A interaction mediates Chk1 phosphorylation by ATR in response to genotoxic stress. in The Journal of biological chemistry 2010 (PubMed)
    Show all 3 references for ABIN1881887

  2. Human Polyclonal TIPIN Primary Antibody for EIA, WB - ABIN493490 : Chou, Elledge: Tipin and Timeless form a mutually protective complex required for genotoxic stress resistance and checkpoint function. in Proceedings of the National Academy of Sciences of the United States of America 2006 (PubMed)
    Show all 2 references for ABIN493490

  3. Chicken Polyclonal TIPIN Primary Antibody for WB - ABIN2784256 : Unsal-Kaçmaz, Chastain, Qu, Minoo, Cordeiro-Stone, Sancar, Kaufmann: The human Tim/Tipin complex coordinates an Intra-S checkpoint response to UV that slows replication fork displacement. in Molecular and cellular biology 2007 (PubMed)

More Antibodies against TIPIN Interaction Partners

Xenopus laevis TIMELESS Interacting Protein (TIPIN) interaction partners

  1. Mta2 (show MTA2 Antibodies) and Tipin cooperate to maintain replication fork integrity, especially on regions that are intrinsically difficult to duplicate.

  2. data indicate that Tipin/Tim1 (show TIMELESS Antibodies)/And1 (show WDHD1 Antibodies) form a complex that links stabilization of replication fork and establishment of sister chromatid cohesion

Human TIMELESS Interacting Protein (TIPIN) interaction partners

  1. TIPIN is important for the maintenance of DNA replication and represents a potential treatment target for the worst prognosis associated breast cancers, such as Triple-negative breast cancer.

  2. Tim-Tipin complex (or Tim alone) is able to associate with DNA polymerase epsilon bound to a 40-/80-mer (show MERTK Antibodies) DNA ligand.

  3. Tim-Tipin complex might play a role in coupling DNA unwinding and DNA synthesis by directly affecting the catalytic activities of replication fork proteins.

  4. We now show that cellular DNA replication fork pausing and protection factors Timeless (show TIMELESS Antibodies) (Tim) and Tipin (Timeless-interacting protein) accumulate at OriP during S phase of the cell cycle.

  5. RPA (show RPA1 Antibodies)-covered ssDNA not only supports recruitment and activation of ATR (show ANTXR1 Antibodies) but also, through Tipin and Claspin (show CLSPN Antibodies), it plays an important role in the action of ATR (show ANTXR1 Antibodies) on its critical downstream target Chk1 (show CHEK1 Antibodies)

  6. The results suggest that Timeless (show TIMELESS Antibodies)-Tipin functions as a replication fork stabilizer that couples DNA replication with sister chromatid cohesion established at replication forks.

  7. Tipin is a checkpoint mediator that cooperates with Tim and may regulate the nuclear relocation of Claspin (show CLSPN Antibodies) in response to replication checkpoint

  8. observation explains the similar checkpoint phenotypes observed in both Tipin- and Timeless (show TIMELESS Antibodies)-depleted cells

  9. TIM and Tipin are functional orthologs of their replisome-associated yeast counterparts capable of coordinating replication with genotoxic stress responses, and distinguishes mammalian TIM from the circadian-specific paralogs.

  10. These findings indicate that the Tim-Tipin complex mediates the UV-induced intra-S checkpoint, Tim is needed to maintain DNA replication fork movement, Tipin interacts with RPA on DNA.

Mouse (Murine) TIMELESS Interacting Protein (TIPIN) interaction partners

  1. mTIM (show TIMELESS Antibodies) promotes the nuclear localization of TIPIN, and TIPIN is capable of regulating mTIM (show TIMELESS Antibodies) activity by disrupting the ability of mTIM (show TIMELESS Antibodies) to form homo-multimeric complexes

  2. TIM and Tipin are functional orthologs of their replisome-associated yeast counterparts capable of coordinating replication with genotoxic stress responses, and distinguishes mammalian TIM from the circadian-specific paralogs.

  3. The tim-Tipin dysfunction creates an indispensible reliance on the ATR (show ATR Antibodies)-Chk1 (show CHEK1 Antibodies) pathway for continued DNA synthesis.

TIPIN Antigen Profile

Protein Summary

Required for normal progression of S-phase. Important for cell survival after DNA damage or replication stress. May be required in the replication checkpoint induced by hydroxyurea or ultraviolet light (By similarity).

Gene names and symbols associated with TIPIN

  • timeless interacting protein (tipin) antibody
  • TIMELESS interacting protein (TIPIN) antibody
  • timeless interacting protein (LOC100359731) antibody
  • timeless interacting protein (Tipin) antibody
  • XTimeless interacting protein (xtipin) antibody
  • 1110005A05Rik antibody
  • 1110018P21Rik antibody
  • MGC82649 antibody
  • RGD1564084 antibody
  • tipin antibody
  • zgc:91928 antibody

Protein level used designations for TIPIN

timeless interacting protein , TIMELESS interacting protein , timeless-interacting protein , TIMELESS-interacting protein , CSM3 homolog , mitotic phosphoprotein 67

GENE ID SPECIES
444047 Xenopus laevis
453525 Pan troglodytes
100126681 Xenopus (Silurana) tropicalis
100359731 Rattus norvegicus
445058 Danio rerio
415548 Gallus gallus
54962 Homo sapiens
100683743 Canis lupus familiaris
506176 Bos taurus
66131 Mus musculus
363076 Rattus norvegicus
394376 Xenopus laevis
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