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Mediates cell survival by inhibiting activation of caspase-9 which prevents induction of apoptosis.. Additionally we are shipping TRIAP1 Antibodies (3) and many more products for this protein.
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crystal structures of free TRIAP1 and TRIAP1-SLMO1 complex reveal how the PRELI domain is chaperoned during import into the intermembrane mitochondrial space; structural resemblance of PRELI-like domain of SLMO1 with that of mammalian phoshatidylinositol transfer proteins suggest they share similar lipid transfer mechanisms
Results describe the upregulation of TRIAP1 in drugresistant breast cancer cells. Its experimental modulation changed breast tumor cells sensitivity to doxorubicin, thus confirming its role in drug resistance.
Loss of TRIAP1 or PRELI (show PRELID1 Proteins) impairs the accumulation of Cardiolipin, facilitates the release of cytochrome c (show CYCS Proteins), and renders cells vulnerable to apoptosis upon intrinsic and extrinsic stimulation.
TRIAP1 is Conserved Specific Coregulators of the p21 (show CDKN1A Proteins):PUMA (show BBC3 Proteins) Expression Ratio.
HSPC132 is p53CSV, a novel p53 (show TP53 Proteins)-inducible gene involved in the p53 (show TP53 Proteins)-dependent cell-survival pathway
Mediates cell survival by inhibiting activation of caspase-9 which prevents induction of apoptosis.
TP53-regulated inhibitor of apoptosis 1
, mitochondrial distribution and morphology 35 homolog
, p53-inducible cell-survival factor
, protein 15E1.1