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TRAF2 and NCK Interacting Kinase Proteins (TNIK)

Germinal center kinases (GCKs), such as TNIK, are characterized by an N-terminal kinase domain and a C-terminal GCK domain that serves a regulatory function (Fu et al., 1999 [PubMed 10521462]).[supplied by OMIM, Mar 2008].. Additionally we are shipping TNIK Antibodies (151) and TNIK Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TNIK 23043 Q9UKE5
TNIK 665113 P83510
Rat TNIK TNIK 294917  
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Top TNIK Proteins at antibodies-online.com

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Baculovirus infected Insect Cells Human GST tag   5 μg Log in to see 10 to 12 Days
$322.08
Details

TNIK Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for TRAF2 and NCK Interacting Kinase (TNIK) Interaction Partners

Human TRAF2 and NCK Interacting Kinase (TNIK) interaction partners

  1. High expression of TNIK in colorectal cancer was associated with recurrence in stage II and III colorectal cancer patients.

  2. Endogenous substrates of TNIK were identified in neurons, along with consensus sequences for TNIK.

  3. nuclear p-TNIK expression was studied in hepatocellular carcinoma, and p-TNIK nuclear expression was associated with poor prognosis and is a candidate prognostic marker for hepatocellular carcinoma

  4. Dynamic change of TNIK offers a way to protect cells from outside stimulus.

  5. TNIK mediates proliferation and survival of EBV-transformed B-cells.

  6. TNIK is essential for the activation of both the canonical Wnt (show WNT2 Proteins) pathway and the JNK (show MAPK8 Proteins) pathway, and serves as a pro-survival factor.

  7. TNIK is a specific effector of Rap2 to regulate actin cytoskeleton

Mouse (Murine) TRAF2 and NCK Interacting Kinase (TNIK) interaction partners

  1. This study demonstrate here that TNIK is expressed in neurons throughout the adult mouse brain.

  2. TNiK is required for dentate gyrus neurogenesis & for pattern separation in a 2-choice spatial discrimination task & for glutamate (show GRIN1 Proteins)-dependent object-location paired associate learning.

  3. TNIK maintains levels of glutamate receptors and other key postsynaptic density (PSD) proteins at the synapse, with loss of TNIK protein or inhibition of TNIK activity causing rapid degradation of PSD constituents.

  4. siRNA depletion of TNIK followed by expression array analysis showed that TNIK is an essential, specific activator of Wnt (show WNT2 Proteins) transcriptional programme.

TNIK Protein Profile

Protein Summary

Germinal center kinases (GCKs), such as TNIK, are characterized by an N-terminal kinase domain and a C-terminal GCK domain that serves a regulatory function (Fu et al., 1999

Gene names and symbols associated with TNIK

  • TRAF2 and NCK interacting kinase (TNIK)
  • TRAF2 and NCK interacting kinase (Tnik)
  • 1500031A17Rik protein
  • 4831440I19Rik protein
  • AI451411 protein
  • C530008O15Rik protein
  • C630040K21Rik protein
  • RGD1561817 protein
  • TNIK protein

Protein level used designations for TNIK

TRAF2 and NCK interacting kinase , TRAF2 and NCK-interacting protein kinase-like , TRAF2 and NCK-interacting protein kinase , traf2 and NCK-interacting protein kinase , Traf2 and NCK interacting kinase

GENE ID SPECIES
100057722 Equus caballus
460849 Pan troglodytes
695414 Macaca mulatta
100437732 Pongo abelii
100603481 Nomascus leucogenys
23043 Homo sapiens
665113 Mus musculus
488166 Canis lupus familiaris
100233204 Sus scrofa
539627 Bos taurus
294917 Rattus norvegicus
424987 Gallus gallus
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