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Involved in modulation of cell growth and cellular response to gamma radiation probably via regulation of the Akt signaling pathway. Additionally we are shipping TSPYL5 Proteins (3) and many more products for this protein.
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TSPYL5 overexpression is associated with Down syndrome.
Suggest that hypermethylation of ACP1 (show ACP1 Antibodies), BMP4 (show BMP4 Antibodies), and TSPYL5 are common events in HCC (show FAM126A Antibodies) and could be used as potentially detectable biomarkers in HCC (show FAM126A Antibodies) tissues.
TSPYL5 knockdown decreased, and overexpression increased aromatase (CYP19A1 (show CYP19A1 Antibodies)) expression through the skin/adipose (I.4) promoter.
Data identify TSPYL5 as a suppressor of p53 (show TP53 Antibodies) function through its interaction with USP7 (show USP7 Antibodies).
This study provides the first demonstration that TSPYL5 modulates cell growth and sensitization of cells to the detrimental effects of damaging agents via regulation of p21(WAF1/Cip1 (show CDKN1A Antibodies)) and PTEN (show PTEN Antibodies)/AKT (show AKT1 Antibodies) pathway.
aberrant methylation at a CpG island of TSPYL5 may play an important role in development of gastric cancers
Involved in modulation of cell growth and cellular response to gamma radiation probably via regulation of the Akt signaling pathway. Involved in regulation of p53/TP53. Suppresses p53/TP53 protein levels and promotes its ubiquitination\; the function is dependent on USP7 and independent on MDM2. Proposed to displace p53/TP53 from interaction with USP7 (By similarity).
TSPY-like protein 5
, testis-specific Y-encoded-like protein 5