Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase (TNKS) ELISA Kits

Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Additionally we are shipping Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase Antibodies (76) and Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase Proteins (3) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
TNKS 8658 O95271
TNKS 21951 Q6PFX9
Anti-Rat TNKS TNKS 290794  
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Top Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase ELISA Kits at antibodies-online.com

Showing 6 out of 14 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human 0.106 ng/mL 0.312-20 ng/mL 96 Tests Log in to see 15 to 17 Days
$908.41
Details
Pig 0.188 ng/mL 0.313-20 ng/mL   96 Tests Log in to see 12 to 14 Days
$715.00
Details
Rabbit 75 pg/mL 125-8000 pg/mL   96 Tests Log in to see 12 to 14 Days
$715.00
Details
Chicken 0.188 ng/mL 0.313-20 ng/mL   96 Tests Log in to see 12 to 14 Days
$715.00
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Monkey 0.188 ng/mL 0.313-20 ng/mL   96 Tests Log in to see 12 to 14 Days
$715.00
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Mouse
  96 Tests Log in to see 15 to 18 Days
$875.60
Details

More ELISA Kits for Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase Interaction Partners

Human Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase (TNKS) interaction partners

  1. The data indicate that the sterile alpha motif domain polymerization is critical for TNKS1 catalytic activity and allows TNKS1 to efficiently access cytoplasmic signaling complexes.

  2. Polymerization is required for Tankyrase to drive beta-catenin (show CTNNB1 ELISA Kits)-dependent transcription. The polymeric state supports PARP (show COL11A2 ELISA Kits) activity and allows Tankyrase to effectively access destruction complexes through enabling avidity-dependent AXIN (show AXIN1 ELISA Kits) binding.

  3. In late S/G2 (show STRN3 ELISA Kits) phase, the DNA damage-responsive E3 ligase RNF8 (show RNF8 ELISA Kits) conjugates K63-linked ubiquitin chains to tankyrase 1, while in G1 phase such ubiquitin chains are removed by BRISC, an ABRO1 (show FAM175B ELISA Kits)/BRCC36 (show BRCC3 ELISA Kits)-containing deubiquitinase complex.

  4. These structural insights will be invaluable for the functional and biophysical characterization of TNKS1/2, including the role of TNKS oligomerization in protein poly(ADP-ribosyl)ation (PARylation) and PARylation-dependent ubiquitylation.

  5. Results describe the structure of three consecutive TNKS- ankyrin repeat clusters (ARCs). Binding analysis indicates specific ARC (show NOL3 ELISA Kits) pairs engage bivalent binding partner Axin1 (show AXIN1 ELISA Kits), and that both rigid and flexible ARC (show NOL3 ELISA Kits) connections form an adaptable TNKS binding platform.

  6. we show for the first time that Tankyrase 1 inhibitior XAV939 was able to significantly increase the apoptosis induced by 5-FU/DDP, accompanied by the protein expression level alternation of b-catenin, Axin and CSC markers in colon cancer cells.

  7. Data show that poly(ADP-ribose) polymerase (PARP (show PARP1 ELISA Kits)) enzyme Tankyrase (TNKS) inhibition in colon cancer cells decreases beta-catenin (show CTNNB1 ELISA Kits) signaling at the level of both Axin (show AXIN1 ELISA Kits) and APC2.

  8. HCMV modulates the activity of TNKS to induce Axin1 (show AXIN1 ELISA Kits), resulting in inhibition of the beta-catenin (show CTNNB1 ELISA Kits) pathway.

  9. Data show that E7449 represents a dual Poly(ADP-ribose) Polymerase 1 (show PARP1 ELISA Kits)/2 and tankyrase 1/2 inhibitor which has the advantage of targeting Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) signaling addicted tumors.

  10. TNKS1 SNPs (rs11991621 rs10503380, and rs7015700) were associated with non-small cell lung cance risk, whereas rs6601328 and rs12541709 inversely associated with risk

Mouse (Murine) Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase (TNKS) interaction partners

  1. These structural insights will be invaluable for the functional and biophysical characterization of TNKS1/2, including the role of TNKS oligomerization in protein poly(ADP-ribosyl)ation (PARylation) and PARylation-dependent ubiquitylation.

  2. analyses also reveal the structural basis for TNKS substrate recruitment, and shed light on the overall structure of TNKS that should help in developing specific inhibitors of Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) signaling

  3. Data show that Tnks1 and 2 are broadly expressed during mouse development and are essential during kidney and lung development. In the kidney, blockage of tankyrase activity phenocopies the effect of blocking production of all Wnt (show WNT2 ELISA Kits) ligands.

  4. Collectively, our data suggest that GSK3 contributes to mitotic tankyrase phosphorylation.

  5. insulin (show INS ELISA Kits)-stimulated insulin-responsive aminopeptidase (show LNPEP ELISA Kits) translocation remained intact despite substantial GLUT4 (show SLC2A4 ELISA Kits) knockdown

  6. tankyrase1 is a poly(ADP-ribose) polymerase (show PARP1 ELISA Kits) with roles in telomere length control by the TRF1 (show TERF1 ELISA Kits) component of the shelterin complex

  7. Tankyrase 1 is essential but redundant for mouse embryonic development

  8. Tankyrase-deficient mice exhibit increases in energy expenditure, fatty acid oxidation, and insulin (show INS ELISA Kits)-stimulated glucose utilization.

Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase (TNKS) Antigen Profile

Antigen Summary

Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles.

Gene names and symbols associated with TNKS

  • si:ch211-155m12.3 (si:ch211-155m12.3) antibody
  • tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase (TNKS) antibody
  • tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase (Tnks) antibody
  • tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase (tnks) antibody
  • 4930554K12Rik antibody
  • AI662855 antibody
  • ARTD5 antibody
  • C86528 antibody
  • D130072O21Rik antibody
  • mTNKS1 antibody
  • PARP-5a antibody
  • PARP5A antibody
  • PARPL antibody
  • pART5 antibody
  • TANK1 antibody
  • tankyrase-1 antibody
  • TIN1 antibody
  • TINF1 antibody
  • TNKS1 antibody
  • wu:fe02c12 antibody

Protein level used designations for TNKS

fe02c12 , tankyrase 1 , ADP-ribosyltransferase diphtheria toxin-like 5 , TANK1 , TNKS-1 , TRF1-interacting ankyrin-related ADP-ribose polymerase , poly [ADP-ribose] polymerase 5A , tankyrase I , tankyrase-1 , TRF1-interacting ankyrin-related ADP-ribose polymerase 1

GENE ID SPECIES
567533 Danio rerio
8658 Homo sapiens
21951 Mus musculus
100036993 Xenopus laevis
374252 Gallus gallus
475603 Canis lupus familiaris
535030 Bos taurus
290794 Rattus norvegicus
100153228 Sus scrofa
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