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The protein encoded by THSD7A is found almost exclusively in endothelial cells from placenta and umbilical cord. Additionally we are shipping THSD7A Kits (5) and THSD7A Proteins (5) and many more products for this protein.
Showing 4 out of 5 products:
Human Polyclonal THSD7A Primary Antibody for IHC, IHC (p) - ABIN4359315
Ek, Andréasson, Hober, Kampf, Pontén, Uhlén, Merz, Borrebaeck: From gene expression analysis to tissue microarrays: a rational approach to identify therapeutic and diagnostic targets in lymphoid malignancies. in Molecular & cellular proteomics : MCP 2006
Show all 2 Pubmed References
High THSD7A expression is associated with membranous nephropathy and cancer.
This study provides novel data on the function of THSD7A in human placental cells, and extends knowledge of how miR (show MLXIP Antibodies)-210 is involved in the development of the preeclampsia.
THSD7A is neural N-glycoprotein, which promotes angiogenesis and it is well known that angiogenesis modulates obesity, adipose metabolism and insulin (show INS Antibodies) sensitivity, hence our result find a correlation.
Data indicate that enhanced granular expression of phospholipase A2 (show YWHAZ Antibodies) receptor (PLA2R (show PLA2R1 Antibodies)) and thrombospondin type-1 domain-containing 7A (THSD7A) was detected in 9.1% and 52.7%, respectively, of the patients with idiopathic membranous nephropathy (MN).
15 of 154 patients with idiopathic membranous nephropathy had circulating autoantibodies to THSD7A but not to PLA2R1 (show PLA2R1 Antibodies), a finding that suggests a distinct subgroup of patients with this condition.
results suggest that Japanese subjects homozygous for the risk alleles of rs7605378 in FONG and rs12673629 in THSD7A have a significantly higher risk of vertebral fracture
THSD7A is a membrane-associated N-glycoprotein with a soluble form.
Thrombospondin type I domain containing 7A (THSD7A) mediates endothelial cell migration and tube formation.
The protein encoded by this gene is found almost exclusively in endothelial cells from placenta and umbilical cord. The encoded protein appears to interact with alpha(V)beta(3) integrin and paxillin to inhibit endothelial cell migration and tube formation. This protein may be involved in cytoskeletal organization. Variations in this gene may be associated with low bone mineral density in osteoporosis.
thrombospondin type-1 domain-containing protein 7A