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THYN1 encodes a protein that is highly conserved among vertebrates and plant species and may be involved in the induction of apoptosis. Additionally we are shipping Thymocyte Nuclear Protein 1 Antibodies (41) and many more products for this protein.
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HSPC144 was expressed and purified, and a stable fragment (residues 44-225) was identified by limited proteolysis method.
The 2.3A-resolution structure revealed only one 2-fold axis of rotational pseudosymmetry. A potential RNA-binding domain from human YTH-domain-containing protein 2 has the most similar 3-D fold to that of the DUF55 domain; it may be an RNA-related domain.
Modulation of Thy28 expression plays a crucial role in the determination of thymic cell fate.
Thy28 regulates mIg (show CXCL9 Proteins)-mediated apoptotic events through the JNK (show MAPK8 Proteins)-H(2)O(2) activation pathway, concomitant with an accumulation of cells in G1 phase associated with upregulation of p27(Kip1 (show CDKN1B Proteins))
down-regulation of the nuclear Thy28 expression appears to correlate with the induction of apoptosis in Ramos B lymphoma cells
This gene encodes a protein that is highly conserved among vertebrates and plant species and may be involved in the induction of apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described.
thymocyte nuclear protein 1
, Putative ortholog of thymocyte nuclear protein 1 (thymocyte nuclear protein 1, Thy28)
, Thymocyte nuclear protein 1
, thymocyte protein thy28
, thymocyte protein Thy28