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TPO encodes a membrane-bound glycoprotein. Additionally we are shipping Thyroperoxidase Antibodies (147) and Thyroperoxidase Kits (70) and many more products for this protein.
Showing 10 out of 52 products:
Human Thyroperoxidase Protein expressed in Escherichia coli (E. coli) - ABIN413833
Kinzfogl, Hangoc, Broxmeyer: Neurexophilin 1 suppresses the proliferation of hematopoietic progenitor cells. in Blood 2011
Two novel inactivating mutations (c.1970T> C and c.2665G> T) in the TPO (show THPO Proteins) gene cause congenital hypothyroidism.
function and autoantigenicity of TPO (show THPO Proteins)
This study confirms the pathogenicity of Y55X mutation in two patients with congenital hypothyroidism and demonstrates that a nonsense mutation in the amino-terminal coding region of the TPO (show THPO Proteins) gene could totally abolish the function of the TPO (show THPO Proteins) enzyme leading to total iodide organification defect.
analysis of thyroid peroxidase autoantibody levels in type 1 diabetes in discordant twin pairs
Data show that thyroperoxidase (TPO) single nucleotide polymorphisms (SNPs) rs4927611 TT and rs732609 CC are genotypes associated with potential risk for the congenital hypothyroidism (CH).
A single base deletion in the carboxyl-terminal coding region of the TPO (show THPO Proteins) gene could cause congenital hypothyroidism and helps to establish a genotype/phenotype correlation associated with the mutation.
Molecular cloning and functional studies of wild type and mutant forms harboring missense mutations in TPO (show THPO Proteins) gene showed decreased activity in the three mutants, higher Km values and lower reaction efficiencies (Vmax/Km).
The effects of inhibition of the TPO (show THPO Proteins)/c-MPL (show MPL Proteins) pathway on enhancing the chemotherapy sensitivity of AML (show RUNX1 Proteins) cells.
perioperative TPO (show THPO Proteins) dynamics are associated with postoperative LD. Postoperative TPO (show THPO Proteins) levels were found to be lowest in high-risk patients (HCC (show FAM126A Proteins) patients undergoing major resection) but showed an independent predictive value.
The detection of the novel c.670_672del and c.1186C>T alterations expand the mutation spectrum of TPO (show THPO Proteins) associated with thyroid dyshormonogenesis.
Hearing impairment in hypothyroid dwarf (show POU1F1 Proteins) mice caused by mutations of the thyroid peroxidase gene.
Findings demonstrate a novel aspect of murine and human thyroid autoimmunity, namely breaking B cell self-tolerance occurs first for Tg and subsequently for TPO (show THPO Proteins).
A novel hypothyroid dwarfism is due to the missense mutation Arg479Cys of the thyroid peroxidase gene in the mouse.
TPO gene was mapped
This gene encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene, but the full-length nature of some variants has not been determined.
, thyroid peroxidase-like
, thyroid microsomal antigen
, thyroid peroxidase (332 AA)