Thyroperoxidase Protein (AA 32-834) (His tag)
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- Target See all Thyroperoxidase (TPO) Proteins
- Thyroperoxidase (TPO) (Thyroid Peroxidase (TPO))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 32-834
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Origin
- Mouse
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This Thyroperoxidase protein is labelled with His tag.
- Purpose
- Mouse Thyroid Peroxidase Protein
- Sequence
- Gly32-Arg834
- Characteristics
- Recombinant Mouse Thyroid Peroxidase Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Gly32-Arg834.
- Purity
- > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
- Sterility
- 0.22 μm filtered
- Endotoxin Level
- Less than 1EU per μg by the LAL method.
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Thyroid Peroxidase (TPO) (AA 19-846) protein (His tag)
TPO Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Thyroid Peroxidase (TPO) (AA 672-779) protein (GST tag)TPO Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Thyroid Peroxidase (TPO) (AA 1-933) protein (GST tag)TPO Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.
- Buffer
- Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.
- Storage
- -20 °C,-80 °C
- Storage Comment
- -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
- Expiry Date
- 12 months
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- Target
- Thyroperoxidase (TPO) (Thyroid Peroxidase (TPO))
- Alternative Name
- Thyroid Peroxidase (TPO Products)
- Synonyms
- MSA Protein, TDH2A Protein, TPX Protein, TPO Protein, msa Protein, tpx Protein, xtpo Protein, LOC100218312 Protein, thyroid peroxidase Protein, TPO Protein, Tpo Protein, tpo Protein, LOC100547103 Protein
- Background
- Thyroid peroxidase, also called thyroperoxidase (TPO) or iodide peroxidase that encodes a 933 amino-acid residue (aa) molecule with a single membrane-spanning region. Thyroid peroxidase plays a key role in thyroid hormone synthesis by catalyzing both the iodination of tyrosine residues to form monoiodotyrosine (MIT) and diiodotyrosine (DIT) residues and the coupling of iodotyrosine residues in Tg, resulting in the formation of T3 and T4. It is a frequent epitope of autoantibodies in autoimmune thyroid disease, for example, the expression of thyroid peroxidase is lost in papillary thyroid carcinoma.
- Molecular Weight
- 90.6 kDa. Due to glycosylation, the protein migrates to 100-115 kDa based on Tris-Bis PAGE result.
- UniProt
- P35419
- Pathways
- Thyroid Hormone Synthesis
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