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TFPI encodes a protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. Additionally we are shipping TFPI Antibodies (184) and TFPI Kits (81) and many more products for this protein.
Showing 10 out of 41 products:
Human TFPI Protein expressed in Human Cells - ABIN2003062
Broze, Warren, Novotny, Higuchi, Girard, Miletich: The lipoprotein-associated coagulation inhibitor that inhibits the factor VII-tissue factor complex also inhibits factor Xa: insight into its possible mechanism of action. in Blood 1988
Show all 5 Pubmed References
Human TFPI Protein expressed in Escherichia coli (E. coli) - ABIN1080946
Gamperl, Plattfaut, Freund, Quecke, Theophil, Gieseler: Extracellular vesicles from malignant effusions induce tumor cell migration: inhibitory effect of LMWH tinzaparin. in Cell biology international 2016
Results suggest that endothelial cell-anchored TFPI controls lung tumor metastasis, and does so largely through the inhibition of local TF-induced thrombin (show F2 Proteins) generation and the regulation of the lung microenvironment in mice.
Data argue against an important role for endogenous TFPI in the antibacterial, inflammatory and procoagulant response during pneumococcal pneumonia.
TFPI has an anti-proliferative role in TNF-alpha (show TNF Proteins) stimulated-VSMCs at least partly by interfering with the MCP-3 (show CCL7 Proteins)/CCR2 (show CCR2 Proteins) pathway and then via suppression of the ERK1/2 and PI3K/AKT (show AKT1 Proteins) signaling pathways
Results demonstrate that TFPI physiologically modulates thrombin (show F2 Proteins)-dependent platelet activation in a manner that is required for successful embryonic development
Tissue factor (show F3 Proteins) plays a hitherto unreported role in the generation of macrophage migratory inhibitory factor by vascular smooth muscle cells in atherosclerosis-prone ApoE (show APOE Proteins)(-/-) mice.
The increased plasmin (show PLG Proteins) generation during the early stages of sepsis could cleave/inactivate TFPI and thus lead to thrombotic complications.
structural features within residues of the 39-loop contribute to the resistance of FIXa (show ETFB Proteins) to inhibition by plasma inhibitors ZPI (show SERPINA10 Proteins) and TFPI.
PAK1 (show PAK1 Proteins) negatively regulates the expression of TFPI and additionally contributes to increased TF activity.
Murine models of combined TFPI and factor VIII deficiency were used to examine the impact of TFPI deficiency on bleeding and clotting in hemophilia
Data demonstrate an inhibitory role for TFPI in angiogenesis that is, in part, mediated through peptides within its carboxyl terminus.
The aim of this study was to evaluate the concentration of TF and its inhibitor TFPI in blood plasma, the impact of traditional and non-traditional cardiovascular risk factors on their concentration and the impact of both markers of haemostasis on the severity of subclinical atherosclerosis.
The results show that cholesterol crystals induce TFPI and cytokine expression in M2-polarized macrophages through activation of the endoplasmic reticulum stress pathway and that TFPI has a protective effect against TNF-alpha (show TNF Proteins) and IL-6 (show IL6 Proteins) mediated inflammation.
Among high-risk women, the tissue factor pathway inhibitor activity of patients with gestational vascular complications is higher than that in other patients. Hence, these markers could augment a screening strategy.
TFPI single nucleotide polymorphism is associated with venous thromboembolism.
a concentration of tissue factor pathway inhibitor was significantly lower in patients with essential thrombocythemia with JAK2 (show JAK2 Proteins) V617F mutation as compared with patients without the mutation
This review presents a comprehensive understanding of TFPI structure, biochemistry, and cellular expression which is necessary to understand how it modulates bleeding in hemophilia and the physiological impact of therapeutic agents targeting TFPI.
the main finding of the current study is the remarkable elevation in the plasma levels of both total and free TFPI in septic patients at baseline. The levels of both forms of the inhibitor remained elevated throughout the first 24 h with further elevation after enoxaparin administration.
TFPI-1 was a valuable predictor of deep venous thrombosis and tumor metastasis in non-small cell lung cancer patients.
Circulating FVII (show F7 Proteins), FVIIa and TFPI were significantly elevated in women with severe preeclampsia in the absence of comparable changes in plasma TF levels.
HIF-1alpha (show HIF1A Proteins) is involved in the transcriptional regulation of the TFPI gene, and suggests that a hypoxic microenvironment inside a breast tumor may induce a procoagulant state in breast cancer patients.
Upregulated TF expression and increased plasma TF level during reperfusion period, reduced plasma TFPI-1 level during reperfusion period.
This gene encodes a protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. The product of this gene inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. The encoded protein is glycosylated and predominantly found in the vascular endothelium and plasma in both free forms and complexed with plasma lipoproteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been confirmed.
extrinsic pathway inhibitor
, lipoprotein-associated coagulation inhibitor
, uncharacterized protein LOC100155068
, tissue factor pathway inhibitor