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TOP1MT encodes a mitochondrial DNA topoisomerase that plays a role in the modification of DNA topology. Additionally we are shipping TOP1MT Antibodies (37) and many more products for this protein.
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Data indicate that the different coordination geometry achieved by the two transition metal ions has an important role in modulating their efficiency as topoisomerase I (show TOP1 Proteins) inhibitors.
DNA topoisomerase I stimulates BLM helicase activity on a nucleolar-relevant RNA:DNA hybrid.
This gene encodes a mitochondrial DNA topoisomerase that plays a role in the modification of DNA topology. The encoded protein is a type IB topoisomerase and catalyzes the transient breaking and rejoining of DNA to relieve tension and DNA supercoiling generated in the mitochondrial genome during replication and transcription. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
DNA topoisomerase I, mitochondrial
, mitochondrial topoisomerase I
, mitochondrial topoisomerase IB
, DNA topoisomerase 1, mitochondrial