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TAAR1 is a G protein-coupled receptor activated by trace amines. Additionally we are shipping TAAR1 Antibodies (46) and many more products for this protein.
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SNPs in human TAAR1 alter its function, resulting in expressed, but functional, sub-functional and non-functional receptors
an increase in TAAR1 receptor expression is concomitant with lymphocyte immune activation, suggesting a possible role for TAAR1 in the generation or regulation of an immune response
biogenic amines potently regulate blood cell functions via TAAR1 and TAAR2 (show TAAR2 Proteins) and open the perspective of their specific pharmacological modulation.
Methamphetamine-but not morphine-induced conditioned place preference was augmented in TAAR1 transgenic mice.
data suggest that TAAR1 and D2R (show DRD2 Proteins) have functional and physical interactions that could be critical for the modulation of the dopaminergic system by TAAR1 in vivo
Overview focuses on recent studies which reveal a role for TAAR1 in the functional regulation of monoamine transporters and the neuronal regulatory mechanisms that modulate dopaminergic activity. [review]
Data support that TAAR1 tonically activates inwardly rectifying K(+) channels, which reduces the basal firing frequency of dopamine neurons in the ventral tegmental area.
A systematic evaluation of a series of beta-phenethylamines as ligands to TAAR1 is reported.
SNP-induced changes in mouse TAAR1 function
Behavioral and physiological studies indicate that TAAR1 function increases sensitivity to aversive effects of Methamphetamine, and may thereby protect against Methamphetamine use.
This study demonstrated that TAAR1 Modulates Cortical Glutamate (show GRIN1 Proteins) NMDA Receptor Function in mouse.
This study report that TAAR1 potentiates the degeneration of dopaminergic neurons and attenuates the behavioral response to l-DOPA and presynaptic and postsynaptic glutamate (show GRIN1 Proteins) neurotransmission in the striatum.
These data demonstrate supersensitivity of postsynaptic D2 dopamine receptors in the striatum of TAAR1-KO mice and indicate that a close interaction of TAAR1 and D2 dopamine receptors.
The data of this study indicated that apomorphine activity at TAAR1 contributes to some behavioral manifestations, particularly climbing.
This study demonistrar=ted (show FAM155B Proteins) that Taar1-mediated modulation of presynaptic dopaminergic neurotransmission: role of D2 dopamine autoreceptors.
These observations confirm the modulatory role of TAAR1 on monoamine activity and suggest that in vivo the receptor is either constitutively active and/or tonically activated by ambient levels of endogenous agonists
Data show that TAARs were expressed only at trace amounts in most of the tissues, the exceptions being TAAR1 in stomach and testis and TAAR8a in intestine, spleen, and testis.
TAAR1 is a G protein-coupled receptor activated by trace amines. Trace amines are endogenous amine compounds that account for less than 1% of the biogenic amines in most brain regions (Bunzow et al., 2001
trace amine associated receptor 1
, trace amine associated receptor 1-like
, trace amine receptor 1
, trace amine-associated receptor 1