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TFCP2 encodes a transcription factor that binds the alpha-globin promoter and activates transcription of the alpha-globin gene. Additionally we are shipping Transcription Factor CP2 Proteins (7) and Transcription Factor CP2 Kits (4) and many more products for this protein.
Showing 10 out of 53 products:
Dog (Canine) Monoclonal TFCP2 Primary Antibody for IF, WB - ABIN968193
Shirra, Zhu, Huang, Pallas, Hansen: One exon of the human LSF gene includes conserved regions involved in novel DNA-binding and dimerization motifs. in Molecular and cellular biology 1994
Show all 2 references for ABIN968193
Chicken Polyclonal TFCP2 Primary Antibody for WB - ABIN2777203
Randall, Strasburger, Prozonic, Morris, Winkie, Parker, Cheng, Fennell, Lanham, Vakil, Huang, Cathcart, Huang, Poduslo: Cluster analysis of risk factor genetic polymorphisms in Alzheimer's disease. in Neurochemical research 2009
Human Polyclonal TFCP2 Primary Antibody for WB - ABIN1109444
Huang, Miller: Cloning of factors related to HIV-inducible LBP proteins that regulate steroidogenic factor-1-independent human placental transcription of the cholesterol side-chain cleavage enzyme, P450scc. in The Journal of biological chemistry 2000
The results suggest potential roles of LSF (TFCP2 ) as a growth regulator through control of the transcription of p21CIP1 (show CDKN1A Antibodies) in melanocytes and melanoma cells as well as a biomarker for nevus.
Complement proteins C7 and CFH (show CFH Antibodies) control the stemness of liver cancer cells via LSF-1 pathway.
LSF is an important mediator in colorectal carcinoma tumorigenesis and progression, and LSF expression is an important index for and prognostic prediction.
Antiproliferative small-molecule inhibitors of transcription factor LSF reveal oncogene (show RAB1A Antibodies) addiction to LSF in hepatocellular carcinoma
Secreted OPN (show SPP1 Antibodies), induced by LSF, activates c-Met via a potential interaction between OPN (show SPP1 Antibodies) and its cell surface receptor CD44 (show CD44 Antibodies). A significant correlation was observed among LSF, OPN (show SPP1 Antibodies), and activated c-Met levels in HCC (show FAM126A Antibodies).
Inhibition of MMP-9 (show MMP9 Antibodies) significantly abrogated LSF-induced angiogenesis as well as in vivo tumorigenesis, thus reinforcing the role of MMP-9 (show MMP9 Antibodies) in facilitating LSF function.
Data suggest that LSF is a key mediator of the Notch1 (show NOTCH1 Antibodies) signaling pathway, suggesting that it might be a novel therapeutic target for the treatment of hepatocellular carcinoma.
Study show that CRTR-1 (show TFCP2L1 Antibodies) is generally an activator of transcription (show STAT1 Antibodies) and that it modulates the activity of other family members, CP2 (show CP Antibodies), NF2d9 (show UBP1 Antibodies) and altNF2d9, in a cell specific manner.
SRY (show SRY Antibodies) is a hybrid of DGCR8 (show DGCR8 Antibodies) and SOX3 (show SOX3 Antibodies), and is regulated by the transcription factor CP2.
The expression of osteopontin (OPN (show SPP1 Antibodies)), a gene regulating every step in tumor progression and metastasis, was robustly up-regulated by LSF.
present study shows that a transcription factor previously unrelated with epithelial-mesenchymal transition (EMT (show ITK Antibodies)), TFCP2c/LSF/LBP-1c, was translocated to the nucleus and bound to the fibronectin (show FN1 Antibodies) promoter upon EMT (show ITK Antibodies) induction by Snail1 (show SNAI1 Antibodies)
the binding of Pin1 (show PIN1 Antibodies) at the Thr (show TRH Antibodies)-329-Pro-330 motif in LSF permits isomerization by Pin1 (show PIN1 Antibodies) of the peptide bonds at the nearby phosphorylated SP motifs (Ser (show SIGLEC1 Antibodies)-291 and Ser (show SIGLEC1 Antibodies)-309) to the trans configuration, thereby facilitating their dephosphorylation.
CP2 contributes to the pathogenesis of Alzheimer's disease by inducing transferrin (show Tf Antibodies) expression via up-regulating its transcription.
CP2 is a major factor in the regulation of globin expression in human and mouse erythroid cells, and CP2 binding to the globin gene promoter is essential for the enhanced transcription of globin genes in erythroid differentiation.
CP2 plays important role during bone development by activating BMP4 (show BMP4 Antibodies) transcription
A novel murine splice isoform of CP2, CP2b (show CYP27B1 Antibodies), which is identical to CP2a except that it has an additional 36 amino acids encoded by an extra exon was identified and characterized.
findings demonstrate that the APLP2-intracellular C-terminal domains interact with CP2 transcription factor in the nucleus and induce the expression of glycogen synthase kinase 3beta
Results identify LSF as only the second known target (in addition to pRb (show PGR Antibodies)) of cyclin C (show CCNC Antibodies)/CDK2 (show CDK2 Antibodies) activity during progression from quiescence to early G(1).
These data suggest that CP2b (show CYP27B1 Antibodies) potentiate erythroid cell-specific alpha-globin (show HBA-A1 Antibodies) expression by recruiting CP2c into the nucleus.
This gene encodes a transcription factor that binds the alpha-globin promoter and activates transcription of the alpha-globin gene. The encoded protein regulates erythroid gene expression, plays a role in the transcriptional switch of globin gene promoters, and it activates many other cellular and viral gene promoters. The gene product interacts with certain inflammatory response factors, and polymorphisms of this gene may be involved in the pathogenesis of Alzheimer's disease.
transcription factor CP2
, cCP2 transcription factor
, SAA3 enhancer factor
, alpha-globin transcription factor CP2