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TFCP2 encodes a transcription factor that binds the alpha-globin promoter and activates transcription of the alpha-globin gene. Additionally we are shipping Transcription Factor CP2 Antibodies (56) and Transcription Factor CP2 Kits (7) and many more products for this protein.
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The results suggest potential roles of LSF (TFCP2 ) as a growth regulator through control of the transcription of p21CIP1 (show CDKN1A Proteins) in melanocytes and melanoma cells as well as a biomarker for nevus.
Complement proteins C7 and CFH (show CFH Proteins) control the stemness of liver cancer cells via LSF-1 pathway.
LSF is an important mediator in colorectal carcinoma tumorigenesis and progression, and LSF expression is an important index for and prognostic prediction.
Antiproliferative small-molecule inhibitors of transcription factor LSF reveal oncogene (show RAB1A Proteins) addiction to LSF in hepatocellular carcinoma
Secreted OPN (show SPP1 Proteins), induced by LSF, activates c-Met via a potential interaction between OPN (show SPP1 Proteins) and its cell surface receptor CD44 (show CD44 Proteins). A significant correlation was observed among LSF, OPN (show SPP1 Proteins), and activated c-Met levels in HCC (show FAM126A Proteins).
Inhibition of MMP-9 (show MMP9 Proteins) significantly abrogated LSF-induced angiogenesis as well as in vivo tumorigenesis, thus reinforcing the role of MMP-9 (show MMP9 Proteins) in facilitating LSF function.
Data suggest that LSF is a key mediator of the Notch1 (show NOTCH1 Proteins) signaling pathway, suggesting that it might be a novel therapeutic target for the treatment of hepatocellular carcinoma.
Study show that CRTR-1 (show TFCP2L1 Proteins) is generally an activator of transcription (show STAT1 Proteins) and that it modulates the activity of other family members, CP2 (show CP Proteins), NF2d9 (show UBP1 Proteins) and altNF2d9, in a cell specific manner.
SRY (show SRY Proteins) is a hybrid of DGCR8 (show DGCR8 Proteins) and SOX3 (show SOX3 Proteins), and is regulated by the transcription factor CP2.
The expression of osteopontin (OPN (show SPP1 Proteins)), a gene regulating every step in tumor progression and metastasis, was robustly up-regulated by LSF.
that yin yang 1 (show YY1 Proteins) strongly localizes in the spermatogonial stem cells and co-localizes heterogeneously with CP2c to permit spermatogenesis
present study shows that a transcription factor previously unrelated with epithelial-mesenchymal transition (EMT (show ITK Proteins)), TFCP2c/LSF/LBP-1c, was translocated to the nucleus and bound to the fibronectin (show FN1 Proteins) promoter upon EMT (show ITK Proteins) induction by Snail1 (show SNAI1 Proteins)
the binding of Pin1 (show PIN1 Proteins) at the Thr (show TRH Proteins)-329-Pro-330 motif in LSF permits isomerization by Pin1 (show PIN1 Proteins) of the peptide bonds at the nearby phosphorylated SP motifs (Ser (show SIGLEC1 Proteins)-291 and Ser (show SIGLEC1 Proteins)-309) to the trans configuration, thereby facilitating their dephosphorylation.
CP2 contributes to the pathogenesis of Alzheimer's disease by inducing transferrin (show Tf Proteins) expression via up-regulating its transcription.
CP2 is a major factor in the regulation of globin expression in human and mouse erythroid cells, and CP2 binding to the globin gene promoter is essential for the enhanced transcription of globin genes in erythroid differentiation.
CP2 plays important role during bone development by activating BMP4 (show BMP4 Proteins) transcription
A novel murine splice isoform of CP2, CP2b (show CYP27B1 Proteins), which is identical to CP2a except that it has an additional 36 amino acids encoded by an extra exon was identified and characterized.
findings demonstrate that the APLP2-intracellular C-terminal domains interact with CP2 transcription factor in the nucleus and induce the expression of glycogen synthase kinase 3beta
Results identify LSF as only the second known target (in addition to pRb (show PGR Proteins)) of cyclin C (show CCNC Proteins)/CDK2 (show CDK2 Proteins) activity during progression from quiescence to early G(1).
This gene encodes a transcription factor that binds the alpha-globin promoter and activates transcription of the alpha-globin gene. The encoded protein regulates erythroid gene expression, plays a role in the transcriptional switch of globin gene promoters, and it activates many other cellular and viral gene promoters. The gene product interacts with certain inflammatory response factors, and polymorphisms of this gene may be involved in the pathogenesis of Alzheimer's disease.
transcription factor CP2
, cCP2 transcription factor
, SAA3 enhancer factor
, alpha-globin transcription factor CP2