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TFR2 encodes a single-pass type II membrane protein, which is a member of the transferrin receptor-like family. Additionally we are shipping Transferrin Receptor 2 Kits (46) and Transferrin Receptor 2 Proteins (14) and many more products for this protein.
Showing 10 out of 64 products:
Human Polyclonal Transferrin Receptor 2 Primary Antibody for EIA, WB - ABIN955173
Ikuta, Yersin, Ikai, Aisen, Kohgo: Characterization of the interaction between diferric transferrin and transferrin receptor 2 by functional assays and atomic force microscopy. in Journal of molecular biology 2010
Show all 4 references for ABIN955173
Human Polyclonal Transferrin Receptor 2 Primary Antibody for WB - ABIN656382
Volke, Gale, Maegdefrau, Schley, Klanke, Bosserhoff, Maxwell, Eckardt, Warnecke: Evidence for a lack of a direct transcriptional suppression of the iron regulatory peptide hepcidin by hypoxia-inducible factors. in PLoS ONE 2009
Show all 2 references for ABIN656382
Cow (Bovine) Polyclonal Transferrin Receptor 2 Primary Antibody for IHC, WB - ABIN2782222
Biasiotto, Camaschella, Forni, Polotti, Zecchina, Arosio: New TFR2 mutations in young Italian patients with hemochromatosis. in Haematologica 2008
These studies further elucidate the role of TFR2 in the regulation of iron homeostasis and its role in regulation of ferroportin (show SLC40A1 Antibodies) and thus macrophage iron homeostasis
Tfr2 is a novel target gene for HNF4alpha (show HNF4A Antibodies), and hepatic HNF4alpha (show HNF4A Antibodies) plays a critical role in iron homeostasis.
There is an essential role for TFR2 in erythropoiesis that may provide new targets for the treatment of anaemia.
We suggest that Tfr2 is a component of a novel iron-sensing mechanism that adjusts erythrocyte production according to iron availability, likely by modulating the erythroblast Epo (show EPO Antibodies) sensitivity.
We propose that TFR2 is a limiting factor for erythropoiesis, particularly in conditions of iron restriction.
These results support in vivo studies which suggest that Hfe (show HFE Antibodies) and Tfr2 can independently regulate hepcidin (show HAMP Antibodies).
we used microarray and real-time reverse transcription polymerase chain reaction to assess brain transcriptome profiles of transferrin receptor 2 mutant mice a model of a rare type of hereditary hemochromatosis (show HFE Antibodies)
Double mutant mice lacking functional Hfe (show HFE Antibodies) or Tfr2 and Tmprss6 (show TMPRSS6 Antibodies) exhibited a severe iron deficiency microcytic anemia phenotype mimicking the phenotype of single mutant mice lacking functional Tmprss6 (show TMPRSS6 Antibodies) demonstrating that Hfe (show HFE Antibodies) and Tfr2 are not substrates for Tmprss6 (show TMPRSS6 Antibodies).
Disruption of both Hfe (show HFE Antibodies) and Tfr2 caused more severe hepatic iron overload with more advanced lipid peroxidation, inflammation, and portal fibrosis than was observed with the disruption of either gene alone.
Tfr2 is not essential for Hfe (show HFE Antibodies)-mediated induction of hepcidin (show HAMP Antibodies) expression, supporting the possibility that TFR2 may regulate iron metabolism in an HFE (show HFE Antibodies)-independent manner.
In line with a status of iron deficiency, gene expression studies suggested decreased expression of transferrin (show Tf Antibodies) and transferrin receptor 2 in non-alcoholic steatohepatitis livers
Our results indicate that membrane transferrin receptor-2, a sensor of circulating iron, is released from the cell membrane in iron deficiency.
results suggest that down-regulation of CD81 (show CD81 Antibodies) by GRAIL (show RNF128 Antibodies) targets TfR2 for degradation
Polymorphisms of the TRF2 (show TERF2 Antibodies) gene may be associated with age-related macular degeneration occurrence, either directly or by modulation of risk factors.
The variants of rs2075674 and rs7385804 in TFR2 gene were not associated with coronary heart disease risk in a Chinese Han population.
Present findings support the hypothesis of a main role of the TFR2 gene in HH pathogenesis in those regions, such as Central-Southern Italy, where the p.C282Y frequency is low.
Authors investigated the expression of TfR1 (show TFRC Antibodies) and TfR2 in human HCC (show FAM126A Antibodies) tissues by immunohistochemistry, the first report demonstrating TfR2 expression immunohistochemically in human HCC (show FAM126A Antibodies).
N-linked glycosylation is dispensable for the cell surface expression and holo-Tf binding, but it is required for efficient intersubunit disulfide bond formation and holo-Tf-induced stabilization of TfR2.
Studies indicate that several genes have been linked to iron homeostasis, including transferrin (show Tf Antibodies) (TF), iron regulatory protein 1 (ACO1 (show ACO1 Antibodies)) and transferrin receptor 2 (TFR2).
The hemochromatosis (show HFE Antibodies) proteins HFE (show HFE Antibodies), TfR2, and HJV (show HFE2 Antibodies) form a membrane-associated protein (show PDZK1IP1 Antibodies) complex for hepcidin (show HAMP Antibodies) regulation.
One novel SNPs was identified in TFR2 which tended to be associated (P < 0.013) with skeletal muscle iron content.
TfR2 is coexpressed with transferrin-a (show Tf Antibodies) in the liver of the zebrafish embryo. Knockdown of TfR2 fails to produce anemia or a morphologic defect.
This gene encodes a single-pass type II membrane protein, which is a member of the transferrin receptor-like family. This protein mediates cellular uptake of transferrin-bound iron, and may be involved in iron metabolism, hepatocyte function and erythrocyte differentiation. Mutations in this gene have been associated with hereditary hemochromatosis type III. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
transferrin receptor 2
, transferrin receptor protein 2-like
, transferrin receptor protein 2