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Transforming acidic coiled-coil proteins are a conserved family of centrosome- and microtubule-interacting proteins that are implicated in cancer. Additionally we are shipping and many more products for this protein.
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These results suggest that TACC2 plays an important role in the cell proliferation of breast carcinoma and therefore immunohistochemical TACC2 status is a candidate of worse prognostic factor in breast cancer cases.
Differential expression of the transcripts TACC2 connects ubiquitin-proteasome system with infection-inflammation in preterm births and preterm premature rupture of membranes.
Data suggest that TACC2 is highly expressed in prostate cancer cells and contributes to cell cycle progression and cell proliferation in androgen-nonresponsive prostate cancer cells; overexpression of TACC2 leads to recurrence of prostate cancer.
Results revealed 3 genes highly predictive of event-free survival (EFS (show EFS Antibodies)), beyond age and MLL (show MLL Antibodies) status: FLT3 (show FLT3 Antibodies), IRX2 (show IRX2 Antibodies), and TACC2.
TACC2 may mediate an oncogenic effect on breast cancer cells.
Defects in TACC2 expression may affect gene regulation, thus contributing to the pathogenesis of some tumors.
GCN5L2 (show KAT2A Antibodies) is a TACC2-binding protein.
Centrosomal TACC2 is required for mitotic spindle maintenance.
Simian virus 40 large T antigen interacting with TACC2 is involved in stabilizing microtubules in mitosis.
Results suggest that TACC2 is not required for mouse development and normal cell proliferation and is not a tumor suppressor protein (show TP53 Antibodies).
Transforming acidic coiled-coil proteins are a conserved family of centrosome- and microtubule-interacting proteins that are implicated in cancer. This gene encodes a protein that concentrates at centrosomes throughout the cell cycle. This gene lies within a chromosomal region associated with tumorigenesis. Expression of this gene is induced by erythropoietin and is thought to affect the progression of breast tumors. Several transcript variants encoding different isoforms have been found for this gene.
, transforming acidic coiled-coil-containing protein 2
, transforming acidic coiled coil 2
, transforming, acidic coiled-coil containing protein 2
, transforming acidic coiled-coil-containing protein 2-like