Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
TRPC1 encodes a melanosomal enzyme that belongs to the tyrosinase family and plays an important role in the melanin biosynthetic pathway. Additionally we are shipping Transient Receptor Potential Cation Channel, Subfamily C, Member 1 Antibodies (69) and Transient Receptor Potential Cation Channel, Subfamily C, Member 1 Kits (3) and many more products for this protein.
Showing 3 out of 6 products:
Endogenous as well as overexpressed xTRPV6 interacts with xTRPC1.
our results suggest that calcium influx through mechanosensitive TRPC1 channels on filopodia activates calpain to control growth cone turning during development.
This study suggested that BDNF (show BDNF Proteins)-induced synaptic potentiation involves coordinated presynaptic and postsynaptic responses and identifies TRPC1 as a molecular mediator for postsynaptic Ca2 (show CA2 Proteins)+ elevation required for BDNF (show BDNF Proteins)-induced synaptic plasticity.
XTRPC1, a Xenopus homolog of mammalian TRPC1, is required for proper growth cone turning responses of Xenopus spinal neurons to netrin-1 (show NTN1 Proteins), brain-derived neurotrophic factor (show BDNF Proteins) and myelin-associated glycoprotein (show MAG Proteins), but not to semaphorin 3A (show SEMA3A Proteins).
downregulation of Xenopus TRP-1 (show TYRP1 Proteins) (xTRPC1) expression with a specific morpholino oligonucleotide abolished the growth-cone turning and Ca2 (show CA2 Proteins)+ elevation induced by a netrin-1 (show NTN1 Proteins) gradient
These results provide the first in vivo evidence that TRPC1 is essential for angiogenesis in zebrafish.
Heteromeric TRPV4 (show TRPV4 Proteins)-TRPC1 channels mediate CaSR (show CASR Proteins)-induced vasorelaxation through NO production but not IKCa channel activation in rabbit mesenteric arteries.
a novel activation mechanism for TRPC1 SOCs in VSMCs, in which store depletion induces formation of TRPC1-Galphaq-PLCbeta1 complexes that lead to PKC stimulation and channel gating.
These observations suggest that mechanical stretch may induce an influx of Ca(2 (show CA2 Proteins)+) and up-regulation of IL-13 (show IL13 Proteins) and MMP-9 (show MMP9 Proteins) expression in 16HBE cells via activation of TRPC1
STIM1L (show STIM1 Proteins) and TRPC1/4 are working together in myotubes to ensure efficient store refilling and a proper differentiation program.
DNA sequencing showed that the patient has carried compound heterozygous mutations of the tyrosinase related protein (TYRP1 (show TYRP1 Proteins)) gene, namely c.1214C>A (p.T405N) and c.1333dupG, which were inherited from his mother and father, respectively.
SARAF (show TMEM66 Proteins) modulates TRPC1, but not TRPC6 (show TRPC6 Proteins), channel function in a STIM1 (show STIM1 Proteins)-independent manner
These findings suggest identification of an important experimental tool compound, which has much higher potency for inhibiting TRPC1/4/5 channels than previously reported agents, impressive specificity, and graded subtype selectivity within the TRPC1/4/5 channel family.
changes in cell cycle regulating genes in TRPC1-silenced cells indicate possible cell cycle arrest along with compensatory up-regulation of ERBB3 (show ERBB3 Proteins) growth factor receptor (show RYK Proteins)-amongst others-to maintain hepatocellular carcinoma cell proliferation.
OC. Our results provide the basis for further investigations of the drug-resistance-related functions of TRPC1 in ovarian cancer and other forms of cancer.
TRPC1 mRNA and protein levels were increased in FCDIa, FCDIIa, and FCDIIb patients.
HIF-1alpha (show HIF1A Proteins) knockdown attenuated hypoxia-induced BMP4 (show BMP4 Proteins) expression and knockdown of either HIF-1alpha (show HIF1A Proteins) or BMP4 (show BMP4 Proteins) abolished hypoxia-induced TRPC expression and basal [Ca(2 (show CA2 Proteins)+)]i.
Single nucleotide polymorphisms in TYRP1 (show TYRP1 Proteins) gene is associated with multiple primary melanoma.
These results indicate the contribution of heteromultimeric channels from TRPC1, TRPC4 (show TRPC4 Proteins), and TRPC5 (show TRPC5 Proteins) subunits to the regulation of mechanisms underlying spatial working memory and flexible relearning by facilitating proper synaptic transmission in hippocampal neurons.
Ca(2 (show CA2 Proteins)+) entry serves critical cellular functions in virtually every cell type, and appropriate regulation of Ca(2 (show CA2 Proteins)+) in neurons is essential for proper function.
Down-regulation of TRPC1 in weight-bearing soleus muscles resulted in reduced muscle mass and reduced myofibre cross-sectional area.
these data indicate for the first time a functional interaction between Orai1 (show TMEM132A Proteins), TRPC1, and CaV1.2 (show CACNA1C Proteins) channels in Vascular Smooth Muscle Cells, confirming that upon agonist stimulation, vessel contraction involves Ca(2 (show CA2 Proteins)+) entry due to co-activation of Orai1 (show TMEM132A Proteins)- and TRPC1-dependent store-operated Ca(2 (show CA2 Proteins)+) channels and L-type Ca(2 (show CA2 Proteins)+) channels.
mechanosensitive TRPC1 channels in murine PSCs exposed to elevated ambient pressure
The results of this study showed that Loss of TRPC1 facilitated the gliotic response induced by increased intraocular pressure (IOP), suggesting that the channel might contribute to the glial mechanosusceptibility.
transient receptor potential channel 1 suppression of basal sphingosine kinase 1 (show SPHK1 Proteins) activity enables endothelial cell-barrier destabilization by edemagenic agonists
Together the data suggests that Ca(2 (show CA2 Proteins)+) entry via the TRPC1 channels is essential for the activation of CaCC (show CLCA1 Proteins)
TRPC1(-/-) mice exhibited decreased survival, severe lung injury, and systemic bacterial dissemination upon infection.
TRPC1 controls the activity of further Ca(2 (show CA2 Proteins)) influx channels and thus regulates the maintenance of intracellular Ca(2 (show CA2 Proteins)) gradients which are critical for cell migration.
the link between HG-induced changes in TRPC1 expression, enhanced Ca(2 (show CA2 Proteins)+) entry, and endothelial dysfunction require further study
Demonstrate a novel role of the NO-cGMP-PKG (show PRKG1 Proteins) pathway in the inhibition of 11,12-EET-induced smooth muscle hyperpolarization and relaxation via PKG (show PRKG1 Proteins)-mediated phosphorylation of TRPC1.
Data found that the pig adrenal medulla expressed predominantly TRPC1, TRPC5 (show TRPC5 Proteins), and TRPC6 (show TRPC6 Proteins) transcripts. The expression level of these TRPCs was significantly elevated in the adrenal medulla from pigs with metabolic syndrome.
This gene encodes a melanosomal enzyme that belongs to the tyrosinase family and plays an important role in the melanin biosynthetic pathway. Defects in this gene are the cause of rufous oculocutaneous albinism and oculocutaneous albinism type III.
transient receptor potential protein
, short transient receptor potential channel 1
, transient receptor potential cation channel, subfamily C, member 1
, transient receptor potential cation channel subfamily C member 1
, short transient receptor potential channel 1-like
, calcium influx channel TRPC1A
, putative calcium influx channel TRPC1A
, transient receptor potential canonical 1
, transient receptor protein 1
, trp-related protein 1
, transient receptor potential channel 1
, store-operated calcium channel
, transient receptor potential channel subfamily C member 1
, 5,6-dihydroxyindole-2-carboxylic acid oxidase
, DHICA oxidase
, catalase B
, glycoprotein 75
, melanoma antigen gp75