Transient Receptor Potential Cation Channel, Subfamily C, Member 3 Proteins (TRPC3)

The protein encoded by TRPC3 is a membrane protein that can form a non-selective channel permeable to calcium and other cations. Additionally we are shipping TRPC3 Antibodies (82) and TRPC3 Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TRPC3 7222 Q13507
TRPC3 22065  
Rat TRPC3 TRPC3 60395  
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Top TRPC3 Proteins at antibodies-online.com

Showing 7 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
Details
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
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HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 2 to 3 Days
$310.00
Details

TRPC3 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, , ,
Mouse (Murine) ,
,

More Proteins for Transient Receptor Potential Cation Channel, Subfamily C, Member 3 (TRPC3) Interaction Partners

Human Transient Receptor Potential Cation Channel, Subfamily C, Member 3 (TRPC3) interaction partners

  1. Data show clear inhibition of the photouncaging- induced Ca2+ signal by the TRPC3 channel inhibitor SKF 96365.

  2. The subsequent ER stress-induced apoptosis exhibit a strong requirement for constitutive Ca(2+) influx and that TRPC3 contributes to this process.

  3. Data show that mechanical stretching of transient receptor potential cation channel, subfamily C, member 3 (TRPC3) overexpressing fibroblasts induced the activation of nuclear factor-kappa B (NFkappaB).

  4. TRPC3 and TRPC6 (show TRPC6 Proteins) participate diversely in synaptic reorganization in the mossy fiber pathway in temporal lobe epilepsy.

  5. the first in vivo evidence for a proatherogenic role of endothelial TRPC3.

  6. Imin channels are regulated by STIM2 (show Stim2 Proteins), TRPC3-containing INS (show INS Proteins) channels are induced by STIM1 (show STIM1 Proteins), and TRPC1 (show TRPC1 Proteins)-composed Imax channels are activated by both STIM1 (show STIM1 Proteins) and STIM2 (show Stim2 Proteins).

  7. CaSR (show CASR Proteins) activation mediates Ca2 (show CA2 Proteins)+ influx and cell proliferation via TRPC3 and TRPC6 (show TRPC6 Proteins) in human mesangial cells

  8. although gene deletion of TRPC3 or TRPC6 (show TRPC6 Proteins) alone did not protect against hypertrophy or dysfunction from pressure overload, combined deletion was protective, supporting the value of dual inhibition

  9. there is an absolute requirement for TRPC3-mediated diacylglycerol-dependent Ca(2 (show CA2 Proteins)+) entry to initiate and sustain the spiking response.

  10. Removal of a large hydrophobic residue (I667A or I667E) generated TRPC3 channels with approximately 60% constitutive activity, suggesting I667 as part of the dynamic structure occluding the permeation path.

Mouse (Murine) Transient Receptor Potential Cation Channel, Subfamily C, Member 3 (TRPC3) interaction partners

  1. In the present study, we have explored the hypothesis that TRPC3 and TRPC6 (show TRPC6 Proteins) channels expressed in VSMCs may have a differential contribution to the regulation of vascular tone, which could be relevant for the changes in vascular reactivity associated with essential hypertension

  2. data suggested Acetylcholine could induce Airway Smooth Muscle Cell proliferation, and TRPC3 may be involved in ACh (show FGFR3 Proteins)-induced ASMC proliferation that occurs with airway remodeling.

  3. The results of this study demonstrated that TRPC3 channels unequivocally contribute to pilocarpine-induced SE and could be a novel molecular target for new anticonvulsive drugs.

  4. Inhibiting TRPC3 with continuous subcutaneous administration of Pyr3 decreased enhanced pause (Penh) of OVA-sensitized mouse. Meanwhile, both Pyr3 and lentiviral shRNA treatment of ASMCs in OVA-sensitized mouse significantly decreased their proliferation and migration

  5. TRPC3 channels are required for the response to glucose of mediobasal hypothalamic glucose-excited neurons and the central effect of glucose on insulin (show INS Proteins) secretion and food intake.

  6. These findings suggest that Trpc3 is a mediator of pathologic cardiac hypertrophy not only through mediating part of the Ca(2 (show CA2 Proteins)+) influx, but also through control of CaV1.2 (show CACNA1C Proteins) expressions.

  7. Data show that mechanical stretching of transient receptor potential cation channel, subfamily C, member 3 (TRPC3) overexpressing fibroblasts induced the activation of nuclear factor-kappa B (NFkappaB).

  8. TRPC3 and TRPC6 (show TRPC6 Proteins) participate diversely in synaptic reorganization in the mossy fiber pathway in temporal lobe epilepsy.

  9. May activate TRPC3 channels to cause extracellular Ca(2 (show CA2 Proteins)+) influx.

  10. These findings provide the first mechanistic insights into the TRPC3- dependent mechanisms, by which activated calcium signaling is coupled to lipid metabolismand the regulation of Purkinje cell development in the Mwk cerebellum.

Pig (Porcine) Transient Receptor Potential Cation Channel, Subfamily C, Member 3 (TRPC3) interaction partners

  1. Demonstrate that Ca(2+) entry via endothelial TRPC3 contributes to nitric oxide release and have revealed that hypoxia-reoxygenation is associated with inhibition of TRPC3 activity.

  2. Study determined the sequence of pig TRPC1 and TRPC3-7 channels and found pig TRPC cDNAs resemble their human homologs more than the others .

  3. heteromeric cation channels comprised of the TRPP2 mutant and the TRPC3 or TRPC7 (show TRPM2 Proteins) protein induce enhanced receptor-activated Ca(2 (show CA2 Proteins)+) influx that may lead to dysregulated cell growth in ADPKD

TRPC3 Protein Profile

Protein Summary

The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with TRPC3

  • transient receptor potential cation channel, subfamily C, member 3 (TRPC3)
  • transient receptor potential cation channel, subfamily C, member 3 (Trpc3)
  • Mwk protein
  • Trcp3 protein
  • Trp3 protein
  • Trpc3 protein
  • TrpC3c protein
  • Trrp3 protein

Protein level used designations for TRPC3

transient receptor potential cation channel, subfamily C, member 3 , short transient receptor potential channel 3-like , short transient receptor potential channel 3 , hTrp-3 , transient receptor protein 3 , TRP-3 , mTrp3 , receptor-activated cation channel TRP3 , trp-related protein 3 , ion channel protein , transient receptor potential cation channel subfamily C member 3 , oocyte transient receptor potential channel

GENE ID SPECIES
100072204 Equus caballus
428766 Gallus gallus
471294 Pan troglodytes
100135636 Cavia porcellus
100454158 Pongo abelii
100483524 Ailuropoda melanoleuca
7222 Homo sapiens
22065 Mus musculus
60395 Rattus norvegicus
483844 Canis lupus familiaris
397210 Sus scrofa
286866 Bos taurus
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