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The protein encoded by TRPC6 forms a receptor-activated calcium channel in the cell membrane. Additionally we are shipping Transient Receptor Potential Cation Channel, Subfamily C, Member 6 Antibodies (130) and Transient Receptor Potential Cation Channel, Subfamily C, Member 6 Proteins (8) and many more products for this protein.
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potential implications of transient receptor potential (TRP) channels in the pathogenesis of intestinal fibrosis, since they are known to act as cellular stress sensors/transducers affecting intracellular Ca(2 (show CA2 ELISA Kits)+) homeostasis/dynamics, and are involved in a broad spectrum of cell pathophysiology including inflammation and tissue remodeling.
Studies provide evidence that the TRPC6-mediated signaling pathway in kidney cells is under control of reactive oxygen species under both physiological and pathological conditions. [review]
SARAF (show TMEM66 ELISA Kits) modulates TRPC1 (show TRPC1 ELISA Kits), but not TRPC6, channel function in a STIM1 (show STIM1 ELISA Kits)-independent manner
Functional interaction of upregulated CaSR (show CASR ELISA Kits) and upregulated TRPC6 in pulmonary artery smooth muscle cells from idiopathic pulmonary arterial hypertension patients may play an important role in the development and progression of sustained pulmonary vasoconstriction and pulmonary vascular remodeling.
Our comprehensive analysis of human disease-causing TRPC6 mutations reveals loss of TRPC6 function as an additional concept of hereditary focal segmental glomerulosclerosis and provides molecular insights into the mechanism responsible for the loss-of-function phenotype of TRPC6 G757D in humans
study demonstrated that the various mechanisms regulating MDR in HCC (show FAM126A ELISA Kits) cells are calcium dependent through the TRPC6/calcium/STAT3 (show STAT3 ELISA Kits) pathway. We propose that targeting TRPC6 in HCC (show FAM126A ELISA Kits) may be a novel antineoplastic strategy, especially combined with chemotherapy
n response to stretching (20%), ATP was released only from the foremost cells at the wound edge; it then diffused to the cells behind the wound edge and activated the P2Y (show P2RY1 ELISA Kits) receptors, which caused propagating Ca(2 (show CA2 ELISA Kits)+) waves via TRPC6
Data suggest that targeted manipulation of protein kinase C (show PKC ELISA Kits) isoforms PKCalpha (show PKCa ELISA Kits), PKCbeta, and PKCeta might be beneficial in certain proteinuric kidney diseases with altered transient receptor potential cation channel subfamily C member 6 protein (TRPC6) functions.
Insulin increases the expression of TRPC6 channels in podocytes by activation of the calcineurin-dependent pathway.
This study described the expression and functional relevance of TRPC6 in the pathophysiology of HK-2 (show HK2 ELISA Kits) cell following ischemia reperfusion.
Administration of soluble klotho (show KL ELISA Kits) significantly reduced obstruction-induced renal fibrosis in wild-type mice, but not in Trpc6 knockout mice, indicating that klotho (show KL ELISA Kits) and TRPC6 inhibition act in the same pathway to protect against obstruction-induced renal fibrosis.
In the present study, we have explored the hypothesis that TRPC3 (show TRPC3 ELISA Kits) and TRPC6 channels expressed in VSMCs may have a differential contribution to the regulation of vascular tone, which could be relevant for the changes in vascular reactivity associated with essential hypertension
This study demonstrated that Transient Receptor Potential Canonical 6 (TRPC6) and Orai2 (show ORAI2 ELISA Kits) form stromal interaction molecule 2 (STIM2 (show Stim2 ELISA Kits))-regulated neuronal-store-operated Ca(2 (show CA2 ELISA Kits)+) influx (nSOC) channel complex in hippocampal synapse and the resulting Ca(2 (show CA2 ELISA Kits)+) influx is critical for long-term maintenance of mushroom spines in hippocampal neurons.
ASIV may prevent HG-induced podocyte apoptosis via downregulation of TRPC6, which is possibly mediated via the calcineurin/NFAT (show NFATC1 ELISA Kits) signaling pathway.
the mTORC2 (show CRTC2 ELISA Kits)/Akt (show AKT1 ELISA Kits)/NFkappaB pathway-mediated activation of TRPC6 participates in adriamycin-induced podocyte apoptosis.
AngII-injured podocyte had a significant increase in apoptosis, while silencing TRPC6 could decrease the apoptosis induced by AngII.
TRPC3 (show TRPC3 ELISA Kits) and TRPC6 participate diversely in synaptic reorganization in the mossy fiber pathway in temporal lobe epilepsy.
the transient receptor potential canonical-6 (TRPC6) calcium-permeable channel in the alveolar macrophages also functions to shunt the transmembrane potential generated by proton pumping.
Selectively activating endothelial TRPC6 rescues transendothelial migration
MicroRNA-26a prevents endothelial cell apoptosis by directly targeting TRPC6 in the setting of atherosclerosis.
These findings suggest that lysoPC induces CaM (show KRIT1 ELISA Kits) phosphorylation at Tyr (show TYR ELISA Kits)(99) by a Src (show SRC ELISA Kits) family kinase and that phosphorylated CaM (show KRIT1 ELISA Kits) activates PI3K to produce PIP3, which promotes TRPC6 translocation to the cell membrane.
analysis of a TRPC6-TRPC5 (show TRPC5 ELISA Kits) channel cascade that restricts endothelial cell movement
Data found that the pig adrenal medulla expressed predominantly TRPC1 (show TRPC1 ELISA Kits), TRPC5 (show TRPC5 ELISA Kits), and TRPC6 transcripts. The expression level of these TRPCs was significantly elevated in the adrenal medulla from pigs with metabolic syndrome.
The protein encoded by this gene forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2).
, short transient receptor potential channel 6
, transient receptor protein 6
, calcium entry channel
, transient receptor potential cation channel, subfamily C, member 6
, transient receptor potential channel subfamily C member 6
, short transient receptor potential channel 6-like