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TRPM6 is predominantly expressed in the kidney and colon, and encodes a protein containing an ion channel domain and a protein kinase domain. Additionally we are shipping TRPM6 Proteins (4) and TRPM6 Kits (3) and many more products for this protein.
Showing 10 out of 44 products:
Mouse (Murine) Polyclonal TRPM6 Primary Antibody for IHC, WB - ABIN351211
Chubanov, Waldegger, Mederos y Schnitzler, Vitzthum, Sassen, Seyberth, Konrad, Gudermann: Disruption of TRPM6/TRPM7 complex formation by a mutation in the TRPM6 gene causes hypomagnesemia with secondary hypocalcemia. in Proceedings of the National Academy of Sciences of the United States of America 2004
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Human Polyclonal TRPM6 Primary Antibody for IHC, WB - ABIN351213
Humphray, Oliver, Hunt, Plumb, Loveland, Howe, Andrews, Searle, Hunt, Scott, Jones, Ainscough, Almeida, Ambrose, Ashwell, Babbage, Babbage, Bagguley, Bailey, Banerjee, Barker, Barlow, Bates, Beasley et al.: DNA sequence and analysis of human chromosome 9. ... in Nature 2004
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Human Polyclonal TRPM6 Primary Antibody for IHC, WB - ABIN351210
Riazanova, Pavur, Petrov, Dorovkov, Riazanov: [Novel type of signaling molecules: protein kinases covalently linked to ion channels] in Molekuliarnaia biologiia 2001
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Human Polyclonal TRPM6 Primary Antibody for IHC, WB - ABIN351212
Schlingmann, Weber, Peters, Niemann Nejsum, Vitzthum, Klingel, Kratz, Haddad, Ristoff, Dinour, Syrrou, Nielsen, Sassen, Waldegger, Seyberth, Konrad: Hypomagnesemia with secondary hypocalcemia is caused by mutations in TRPM6, a new member of the TRPM gene family. in Nature genetics 2002
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Rat (Rattus) Polyclonal TRPM6 Primary Antibody for IHC - ABIN351209
Grimm, Kraft, Sauerbruch, Schultz, Harteneck: Molecular and functional characterization of the melastatin-related cation channel TRPM3. in The Journal of biological chemistry 2003
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Mouse (Murine) Polyclonal TRPM6 Primary Antibody for IHC, WB - ABIN351214
Kiessling, Füssel, Schmitz, Stevanovic, Meye, Weigle, Klenk, Wirth, Rieber: Identification of an HLA-A*0201-restricted T-cell epitope derived from the prostate cancer-associated protein trp-p8. in The Prostate 2003
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The Different Roles of The Channel-Kinases TRPM6 and TRPM7 (show TRPM7 Antibodies)
we showed that two serum magnesium associated loci, MUC1 (show MUC1 Antibodies) and TRPM6, had significant effect modification with progestin use and insulin (show INS Antibodies) levels, respectively, in European Americans.
N-Myc (show MYCN Antibodies) can promote neuroblastoma (show ARHGEF16 Antibodies) cell proliferation through up-regulation of the channel kinases TRPM6 and TRPM7 (show TRPM7 Antibodies)
TRPM6 mRNA and protein levels in atrial fibrillation group were elevated markedly in comparison with sinus rhythm group.
Knowledge of TRPM6 functioning is of vital importance to decipher its role in Mg handling and will, in particular, provide a molecular basis for achieving a better understanding of Mg mal (show MAL Antibodies)(re)absorption and hence systemic Mg balance.
Data indicate heteromer formation between channel kinases TRPM6 and TRPM7 (show TRPM7 Antibodies) influences the biological activity of the ion channels.
We conclude that the new TRPM6 missense mutations lead to dysregulated intestinal/renal Mg(2 (show MUC7 Antibodies)+) (re)absorption as a consequence of loss of TRPM6 channel function.
TRPM6 kinase activity is linked to channel activity through a kinase-independent mechanism involving the dimerization motif binding to a pocket within the kinase domain.
TRPM6 modulates the functionality of TRPM7 (show TRPM7 Antibodies), and the TRPM6 kinase plays a critical role in tuning the phenotype of the TRPM7 (show TRPM7 Antibodies).M6 channel complex.
PIP2 is required for TRPM6 channel function; hydrolysis of PIP2 by PLC (show HSPG2 Antibodies)-coupled hormones/agonists may constitute an important pathway for TRPM6 gating, and perhaps Mg2 (show MUC7 Antibodies)+ homeostasis.
in a model of inherited hypomagnesemia, TRPM6 and TRPM7 (show TRPM7 Antibodies), but not paracellin-1 (show CLDN16 Antibodies), are downregulated
TRPM6 deletion is embryonic lethal in mice; Heterozygous deletion of TRPM6 results in a mild hypomagnesemia
consistently reduced expression of TRPM6 mRNA may play a role in the pathogenesis of hypomagnesemia in C57BL/6 asthmatic mice.
MsrB1 (show SEPX1 Antibodies) recovers TRPM6 channel activity by reducing the oxidation of Met(1755) and could, thereby, function as a modulator of TRPM6 during oxidative stress.
Trpm6(-/-) mice almost never survived to weaning and show neural tube defects.
In C57BL/6J mice, dietary Mg(2 (show MCOLN1 Antibodies)+)-restriction results in increased Mg(2 (show MCOLN1 Antibodies)+) (re)absorption, which is correlated with increased TRPM6 expression.
REA (show PHB2 Antibodies) operates as a negative feedback modulator of TRPM6 in the regulation of active Mg(2 (show MCOLN1 Antibodies)+) (re)absorption and provides new insight into the molecular mechanism of renal transepithelial Mg(2 (show MCOLN1 Antibodies)+) transport.
Modulation of TRPM6 and Na(+)/Mg(2 (show MCOLN1 Antibodies)+) exchange in mammary epithelial cells in response to variations of magnesium availability.
This gene is predominantly expressed in the kidney and colon, and encodes a protein containing an ion channel domain and a protein kinase domain. It is crucial for magnesium homeostasis, and plays an essential role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. Mutations in this gene are associated with hypomagnesemia with secondary hypocalcemia. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
transient receptor potential cation channel, subfamily M, member 6
, channel kinase 2
, melastatin-related TRP cation channel 6
, transient receptor potential cation channel subfamily M member 6
, transient receptor potential cation channel 6/channel-kinase 2