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Transition Protein 1 (During Histone To Protamine Replacement) Proteins (TNP1)

Transition protein-1 is a spermatid-specific product of the haploid genome which replaces histone and is itself replaced in the mature sperm by the protamines (see PRM1, MIM 182880\; PRM2, MIM 182890) (Luerssen et al., 1990 [PubMed 2249851]).[supplied by OMIM, Mar 2008].. Additionally we are shipping TNP1 Antibodies (25) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TNP1 21958 P10856
TNP1 24839 P02317
TNP1 7141 P09430
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Top TNP1 Proteins at antibodies-online.com

Showing 7 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,031.33
Details
Yeast Sheep His tag   1 mg Log in to see 56 to 66 Days
$2,031.33
Details
Yeast Wild boar His tag   1 mg Log in to see 56 to 66 Days
$2,031.33
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,031.33
Details

TNP1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Rat (Rattus)

Human ,
,

More Proteins for Transition Protein 1 (During Histone To Protamine Replacement) (TNP1) Interaction Partners

Mouse (Murine) Transition Protein 1 (During Histone To Protamine Replacement) (TNP1) interaction partners

  1. The elevated levels of the remaining TP in Tnp-mutant mice appeared to be a consequence of the prolonged nucleus retention, rather than increased synthesis.

  2. Epididymal sperm from the Tnp1 null genotypes demonstrated a general decrease in normal morphology, motility, chromatin condensation, and degree of protamine 2 (show PRM2 Proteins) processing with decreasing levels of transition proteins in mutant sperm.

  3. JHDM2A (show KDM3A Proteins) directly binds to and controls the expression of transition nuclear protein 1 (show NUPR1 Proteins) (Tnp1) and protamine 1 (Prm1 (show PRM1 Proteins)) genes, the products of which are required for packaging and condensation of sperm chromatin

Human Transition Protein 1 (During Histone To Protamine Replacement) (TNP1) interaction partners

  1. Among Systemic lupus erythematosus patients, 63.6% and 45.5% of those with lupus nephritis were positive for anti-RRP8 (show RRP8 Proteins) and anti-TNP1 antibodies, compared with 12.5% and 9.4% of Systemic lupus erythematosus patients without nephritis, respectively.

  2. frequency of the haplotype GCG (show GCG Proteins) (H3) was increased in azoospermic men compared with fertile men. expression analysis of the TNP1 gene in obstructive azoospermic men showed that haplotypes of the TNP1 gene do not affect its expression level.

  3. a deletion of 15 nucleotides encompassing the recognition site for the cAMP response element transcription factor was found in the 5'-promoter region of the TNP1 gene in infertile men; this deletion reduces TNP1 expression and may cause infertility

  4. We found significantly lower levels of HILS1, TNP1, and TNP2 (show TNP2 Proteins) transcripts in spermatozoa from asthenozoospermic men compared to normozoospermic men.

  5. The TNP1 contributes not only to successful fertilization, but may has an important impact in development of preimplantation embryos.

  6. The presence of transition proteins (TP1 (show RPLP2 Proteins) and/or TP2 (show TERT Proteins)) in spermatids in semen indicates inhibition in the differentiation pathway from round spermatids to spermatozoa in infertile men.

Cow (Bovine) Transition Protein 1 (During Histone To Protamine Replacement) (TNP1) interaction partners

  1. We propose that SNPs on the TNP1 3'-UTR may help select semen quality trait in Chinese Holstein bulls in the dairy industry.

TNP1 Protein Profile

Protein Summary

Transition protein-1 is a spermatid-specific product of the haploid genome which replaces histone and is itself replaced in the mature sperm by the protamines (see PRM1, MIM 182880\; PRM2, MIM 182890) (Luerssen et al., 1990

Gene names and symbols associated with TNP1

  • transition protein 1 (during histone to protamine replacement) (TNP1)
  • transition protein 1 (during histone to protamine replacement) (LOC100349146)
  • spermatid nuclear transition protein 1-like (LOC100513764)
  • transition protein 1 (Tnp1)
  • Stp-1 protein
  • TNP1 protein
  • Tp-1 protein
  • TP1 protein

Protein level used designations for TNP1

transition protein 1 (during histone to protamine replacement) , Spermatid nuclear transition protein 1 , spermatid nuclear transition protein 1 , STP-1 , TP-1 , testis-specific basic protein

GENE ID SPECIES
696593 Macaca mulatta
100349146 Oryctolagus cuniculus
740418 Pan troglodytes
100630835 Equus caballus
100513764 Sus scrofa
21958 Mus musculus
24839 Rattus norvegicus
7141 Homo sapiens
100686780 Canis lupus familiaris
407743 Sus scrofa
281537 Bos taurus
101108026 Ovis aries
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