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mouse homolog is a translocase of the inner mitchondrial membrane; essential for cell viability. Additionally we are shipping Translocase of Inner Mitochondrial Membrane 23 Homolog (Yeast) Antibodies (10) and many more products for this protein.
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Heterozygote Tim23 knockout mice exhibit a reduced lifespan and defective mitochondrial import.
Modulating the sorting of nuclear-encoded proteins into mitochondria, mediated by the TIM23 complex, proves therapeutic in both yeast and patient-derived cells exhibiting ATP synthase deficiency.
Three distinct Tim23 complexes, namely, B1, B2, and A, are involved in the maintenance of normal mitochondrial function.
GST pull-down experiments and tryptophan fluorescence indicated that there is no interaction between Tim23IMS and Tim50IMS
MCJ functions as J co-chaperone of the human TIM23 pre-protein translocase.
Study establishes an unexpected molecular link between the TIM23 transport machinery and assembly of respiratory-chain complexes that regulate mitochondrial protein (show COX6B2 ELISA Kits) synthesis in response to their assembly state.
The non-bound hydrophilic domain of the human Tim23 is in a molten globule configuration with marginal stability, existing as a dimer.
The protein encoded by this gene is part of a complex located in the inner mitochondrial membrane that mediates the transport of transit peptide-containing proteins across the membrane. Multiple transcript variants, one protein-coding and others not protein-coding, have been found for this gene.
mitochondrial import inner membrane translocase subunit Tim23
, translocase of inner mitochondrial membrane 23 homolog