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Transmembrane Channel-Like 6 Proteins (TMC6)

Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. Additionally we are shipping Transmembrane Channel-Like 6 Antibodies (46) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TMC6 11322 Q7Z403
TMC6 217353 Q7TN60
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Top Transmembrane Channel-Like 6 Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 59 to 64 Days
$8,623.45
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 59 to 64 Days
$6,052.17
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details

TMC6 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine) ,
,

More Proteins for Transmembrane Channel-Like 6 (TMC6) Interaction Partners

Human Transmembrane Channel-Like 6 (TMC6) interaction partners

  1. Findings suggest that SNP in EVER 1 may be involved in the development of premalignant skin lesions that harbour beta-HPV, perhaps giving rise to SCC (show CYP11A1 Proteins) tumours that have lost beta-HPV gene expression during progression

  2. TMC6/EVER1 and TMC8/EVER2 (show TMC8 Proteins) are known to be involved in the development of EV.

  3. TMC6 variants are associated with diminished age-of-onset of P. aeruginosa airway infection in children with cystic fibrosis (show S100A8 Proteins).

  4. EV is also a rare autosomal recessive genodermatosis involving susceptibility to human papillomavirus (HPV) infections and squamous cell carcinoma, caused in most cases by homozygous mutations in EVER1 or EVER2 (show TMC8 Proteins).

  5. Expression of both EVER1 and EVER2 (show TMC8 Proteins) in B cells is activated immediately after Epstein-Barr virus (EBV) infection, whereas at later stages, it is strongly repressed by latent membrane protein 1-activated NF-kappaB (show NFKB1 Proteins) signaling.

  6. Data support the involvement of the TMC6/8 region in cervix cancer susceptibility.

  7. Mutations in EVER1 are associated with epidermodysplasia verruciformis.

  8. four mutations in recurrent respiratory papillomatosis patients might indicate that EVER 1 alleles are not associated with susceptibility to RRP (show RRBP1 Proteins)

  9. The growing number of mutations in epidermodysplasia verruciformis (EV) pedigrees supports the hypothesis that EVER1 and EVER2 (show TMC8 Proteins) are the molecular basis of EV.

  10. HPV16 E5 protein binds to EVER and ZnT-1 and blocks their negative regulation

Transmembrane Channel-Like 6 (TMC6) Protein Profile

Protein Summary

Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 10 transmembrane domains and 2 leucine zipper motifs.

Gene names and symbols associated with TMC6

  • transmembrane channel-like 6 (TMC6)
  • transmembrane channel-like 6b (tmc6b)
  • transmembrane channel-like 6 (tmc6)
  • transmembrane channel-like 6 (LOC100218212)
  • transmembrane channel-like gene family 6 (Tmc6)
  • D11Ertd204e protein
  • EV1 protein
  • ever1 protein
  • EVIN1 protein
  • LAK-4P protein
  • MGC83549 protein
  • zgc:92610 protein

Protein level used designations for TMC6

transmembrane channel-like 6 , epidermodysplasia verruciformis 1 , transmembrane channel-like protein 6 , transmembrane channel-like protein 6-like , epidermodysplasia verruciformis protein 1 , expressed in activated T/LAK lymphocytes , protein LAK-4

GENE ID SPECIES
422089 Gallus gallus
436978 Danio rerio
483341 Canis lupus familiaris
505575 Bos taurus
444078 Xenopus laevis
100058089 Equus caballus
100218212 Taeniopygia guttata
100380197 Xenopus (Silurana) tropicalis
100443349 Pongo abelii
100546520 Meleagris gallopavo
100597507 Nomascus leucogenys
11322 Homo sapiens
217353 Mus musculus
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