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Modulates the O-glycosylation and complex N- glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. Additionally we are shipping TMEM59 Antibodies (28) and many more products for this protein.
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The TMEM59 gene identified from our discovery approach was recently implicated in amyloid-beta protein precursor post-translational processing, supporting a role for epigenetic change in LOAD pathology.
TMEM59 affects amyloid precursor protein (show APP Proteins) shedding by reducing its acccess to cellular components.
MicroRNA-351 regulates TMEM 59 (DCF1) expression and mediates neural stem cell morphogenesis.
The expression of tmem59 is an important factor contributing to Alzheimer's disease.
Chromosome mapping of 3 proteins (CRSP9 (show MED7 Proteins), ETF1 (show ETF1 Proteins) and TMEM59) in swine
Modulates the O-glycosylation and complex N- glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. Inhibits APP transport to the cell surface and further shedding (By similarity).
transmembrane protein 59
, liver membrane-bound protein
, thymic dendritic cell-derived factor 1