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TRIB2 encodes one of three members of the Tribbles family. Additionally we are shipping Tribbles Homolog 2 (Drosophila) Proteins (12) and many more products for this protein.
Showing 10 out of 68 products:
Human Monoclonal TRIB2 Primary Antibody for IHC (p), RNAi - ABIN565396
Wang, Zhang, Weng, Qiao, Ma, Xiao, Yu, Pan, Sun et al.: Impaired phosphorylation and ubiquitination by p70 S6 kinase (p70S6K) and Smad ubiquitination regulatory factor 1 (Smurf1) promote tribbles homolog 2 (TRIB2) stability and carcinogenic property in ... in The Journal of biological chemistry 2013
Show all 3 Pubmed References
Human Polyclonal TRIB2 Primary Antibody for ICC, IF - ABIN4362344
Sung, Francis, Arnold, Holland, Ernst, Angyal, Kiss-Toth: Enhanced macrophage tribbles-1 expression in murine experimental atherosclerosis. in Biology 2014
tissues expressing the highest levels of Xtrb2 were most markedly affected by morpholino knockdown, with perturbation of neural crest and eye development
O-GlcNAcylation of TRIB2 might be critical for diabetes-associated liver cancer.
Tumors from resistant patients expressed the lowest levels of TRIB2. Downregulation of TRIB2 contributes to platin-resistance.
our data show that excess p30 (show CENPV Antibodies) cooperated with TRIB2 only in the presence of p42 (show EPB42 Antibodies) to accelerate acute myeloid leukaemia (AML (show RUNX1 Antibodies)), and the direct interaction and degradation of C/EBPa (show CEBPA Antibodies) p42 (show EPB42 Antibodies) is required for TRIB2-mediated AML (show RUNX1 Antibodies).
miR (show MLXIP Antibodies)-206 and miR (show MLXIP Antibodies)-140, as tumor suppressors, induced lung adenocarcinoma cell death and inhibited cell proliferation by modifying oncogenic TRIB2 promoter activity through p-Smad3 (show SMAD3 Antibodies).
Studied effect of TRIB2 SNP on the expression of genes involved in adaptive thermogenesis using messenger RNAs prepared from adipose tissues of Japanese adults. Of the five thermogenic genes, DIO2 (show DIO2 Antibodies), CIDEA (show CIDEA Antibodies), PPARGC1A (show PPARGC1A Antibodies), and PRDM16 (show PRDM16 Antibodies) showed significantly higher transcript levels in SAT of individuals with the AA genotype relative to those with the AT + TT genotype.
Data show that TRIB2-mediated degradation of CDC25C (show CDC25C Antibodies) is associated with lysine-48-linked CDC25C (show CDC25C Antibodies) polyubiquitination driven by the TRIB2 kinase-like domain.
High TRIB2 reinforces the oncogenic transcriptional program controlled by the TAL1 (show TAL1 Antibodies) complex in T-cell acute lymphoblastic leukemia.
Studies suggest that pseudo-kinase family of tribbles (show TRIB1 Antibodies) (TRIB) proteins TRIB1 (show TRIB1 Antibodies), TRIB2 and TRIB3 (show TRIB3 Antibodies) play roles in pathogenesis of rheumatoid arthritis (RA) and osteoarthritis.
Studies suggest that pseudo-kinase family of tribbles (show TRIB1 Antibodies) (TRIB) proteins TRIB1 (show TRIB1 Antibodies), TRIB2 and TRIB3 (show TRIB3 Antibodies) were involved in the pathogenesis of inflammation.
Studies suggest that tribbles homolog 2 (Drosophila) protein (TRIB2) as a meaningful biomarker to both diagnose and stage melanoma.
The absence of a change in hypocretin (show OX Antibodies) cell populations suggested that factors other than anti-TRIB2 antibody play a part in the loss of hypocretin (show OX Antibodies) neurons in narcolepsy. The increased anti-TRIB2 antibody after the destruction of hypocretin (show OX Antibodies) neurons suggest that anti-TRIB2 antibody in narcolepsy patients is the consequence rather than the inciting cause of hypocretin (show OX Antibodies) cell destruction.
These data indicate that Trib2 has a complex role in the pathogenesis of Notch (show NOTCH1 Antibodies)-driven T-ALL, which may vary between different T-ALL subtypes.
TRIB1 (show TRIB1 Antibodies) and TRIB3 (show TRIB3 Antibodies) are more strongly expressed than TRIB2 in cumulus cells (CC) surrounding oocytes from preovulatory follicles than in CC of immature ones.
we identify the contribution of dysregulated C/EBPalpha (show CEBPA Antibodies) and E2F1 (show E2F1 Antibodies) to elevated Trib2 expression and leukemic cell survival
Trib2 transduced hematopoietic stem cells developed acute myeloid leukemia (show BCL11A Antibodies).
Elevated Tribbles homolog 2-specific antibody levels in narcolepsy patients.
Data identify Tribbles homolog 2 as an oncogene (show RAB1A Antibodies) that induces acute myelogenous leukemia through a mechanism involving inactivation of C/EBPalpha (show CEBPA Antibodies).
describe suppression of adipocyte differentiation by TRBs Trib1 (show TRIB1 Antibodies), Trib2, Trib3 (show TRIB3 Antibodies)
Mice reconstituted with HSC (show FUT1 Antibodies) cotransduced with HoxA9 (show HOXA9 Antibodies) and Trib2 had accelerated onset of AML (show RUNX1 Antibodies) compared to either gene alone
Linkage of Meis1 (show MEIS1 Antibodies) leukemogenic activity to multiple downstream effectors including Trib2 and Ccl3 (show CCL3 Antibodies).
This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene.
tribbles homolog 2 (Drosophila)
, tribbles homolog 2-like
, tribbles homolog 2
, serine/threonine protein kinase
, tribbles-like protein 2