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TREML1 is located in a gene cluster on chromosome 6 with the single Ig variable (IgV) domain activating receptors TREM1 (MIM 605085) and TREM2 (MIM 605086), but it has distinct structural and functional properties. Additionally we are shipping Triggering Receptor Expressed On Myeloid Cells-Like 1 Proteins (14) and Triggering Receptor Expressed On Myeloid Cells-Like 1 Kits (11) and many more products for this protein.
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Human Polyclonal TREML1 Primary Antibody for ELISA - ABIN1999415
Washington, Quigley, McVicar: Initial characterization of TREM-like transcript (TLT)-1: a putative inhibitory receptor within the TREM cluster. in Blood 2002
Show all 5 references for 1999415
Human Polyclonal TREML1 Primary Antibody for FACS, WB - ABIN4899272
Giomarelli, Washington, Chisholm, Quigley, McMahon, Mori, McVicar: Inhibition of thrombin-induced platelet aggregation using human single-chain Fv antibodies specific for TREM-like transcript-1. in Thrombosis and haemostasis 2007
Platelet-derived soluble TLT-1 is a potent endogenous regulator of sepsis-associated inflammation.
These results suggest that during inflammation, sTLT-1 may mediate hemostasis by enhancing actin polymerization, resulting in increased platelet aggregation and adherence to the endothelium.
initial characterization of TREM-like transcript (TLT)-1 results indicate it is likely that TLT-1 regulates the signaling of the TREM family receptors(TLT-1)
In contrast to previously characterized immunoreceptor tyrosine-based inhibition motif (ITIM) receptors, TLT1 enhances rather than inhibits calcium signaling in rat RBL-2H3 cells, a property dependent on the SHP-2 recruiting classical Tyr281 ITIM.
A soluble fragment of the TLT-1 extracellular domain is found in serum of humans and mice and that an isoform of similar mass is released from platelets following activation with thrombin (show F2 Antibodies).
Define a platelet specific function for TLT1 in regulation of aggregation.
Phenotypic heterogeneity in the Gray platelet syndrome extends to the expression of TREM family member, TLT-1.
TLT-1 plays a protective role during inflammation by dampening the inflammatory response and facilitating platelet aggregation at sites of vascular injury
TLT (show OTOP1 Antibodies)-1s, alternative transcripts of triggering receptor expressed on myeloid cell-like transcript-1 (TLT-1), Inhibits the triggering receptor expressed on myeloid cell-2 (TREM-2 (show TREM2 Antibodies))-mediated signaling pathway during osteoclastogenesis.
initial characterization of TREM-like transcript (TLT)-1; results indicate it is likely that TLT-1 regulates the signaling of the TREM family receptors
This gene encodes a member of the triggering receptor expressed on myeloid cells-like (TREM) family. The encoded protein is a type 1 single Ig domain orphan receptor localized to the alpha-granule membranes of platelets. The encoded protein is involved in platelet aggregation, inflammation, and cellular activation and has been linked to Gray platelet syndrome. Alternative splicing results in multiple transcript variants
triggering receptor expressed on myeloid cells-like 1
, trem-like transcript-1-like
, trem-like transcript 1 protein
, triggering receptor expressed on myeloid cells-like protein 1
, triggering receptor expressed on myeloid cells-like 1c
, triggering receptor expressed on myeloid cells-like 1d
, triggering receptor expressed on myeloid cells-like 1e