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The protein encoded by TRIM23 is a member of the tripartite motif (TRIM) family. Additionally we are shipping Tripartite Motif Containing 23 Antibodies (64) and many more products for this protein.
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Our results indicate that TRIM23 enzymatic activity requires RING dimerization, consistent with the general model of TRIM (show TRAT1 Proteins) activation
TRIM23 regulates adipocyte differentiation via stabilization of the adipogenic activator PPARgamma2 (show PPARG Proteins).
conclude that TRIM23-mediated ubiquitin conjugation to NEMO (show IKBKG Proteins) is essential for TLR3 (show TLR3 Proteins)- and RIG-I (show DDX58 Proteins)/MDA5 (show IFIH1 Proteins)-mediated antiviral innate and inflammatory responses
Data are consistent with a potential function for ADP-ribosylation factor domain protein 1 (show ARF1 Proteins) as an E3 ubiquitin ligase (show MUL1 Proteins) in cells.
The authors present a novel role for TRIM23 that is specific to UL144-mediated activation of NF-kappaB (show NFKB1 Proteins) during the course of virus infection.
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein is also a member of the ADP ribosylation factor family of guanine nucleotide-binding family of proteins. Its carboxy terminus contains an ADP-ribosylation factor domain and a guanine nucleotide binding site, while the amino terminus contains a GTPase activating protein domain which acts on the guanine nucleotide binding site. The protein localizes to lysosomes and the Golgi apparatus. It plays a role in the formation of intracellular transport vesicles, their movement from one compartment to another, and phopholipase D activation. Three alternatively spliced transcript variants for this gene have been described.
GTP-binding protein ARD-1
, tripartite motif-containing 23
, ADP-ribosylation factor domain protein 1
, ADP-ribosylation factor domain protein 1, 64kDa
, ADP-ribosylation factor domain-containing protein 1
, ARF domain protein 1
, E3 ubiquitin-protein ligase TRIM23
, RING finger protein 46
, tripartite motif protein TRIM23
, tripartite motif-containing protein 23
, ADP-ribosylation factor domain protein 1, 64kD
, tripartite motif protein 23
, ADP-ribosylation factor domain protein 1 64kD
, nucleotide binding protein