Tripartite Motif Containing 8 Proteins (TRIM8)

The protein encoded by TRIM8 is a member of the tripartite motif (TRIM) family. Additionally we are shipping TRIM8 Antibodies (45) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TRIM8 81603 Q9BZR9
TRIM8 93679 Q99PJ2
Rat TRIM8 TRIM8 688785  
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Top TRIM8 Proteins at

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
HOST_Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days

TRIM8 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

More Proteins for Tripartite Motif Containing 8 (TRIM8) Interaction Partners

Human Tripartite Motif Containing 8 (TRIM8) interaction partners

  1. we provided evidence that TRIM8 and its regulators miR-17-5p and miR (show MLXIP Proteins)-106b-5 participate to a feedback loop controlling cell proliferation through the reciprocal modulation of p53 (show TP53 Proteins), miR (show MLXIP Proteins)-34a and N-MYC (show MYCN Proteins).

  2. A pathogenic effect of a heterozygous truncating mutation in the tripartite motif containing 8 (TRIM8) gene on the postnatal development of the human brain.

  3. Our study provides evidences that TRIM8 may participate in the carcinogenesis and progression of glioma and that the transcriptional repression of TRIM8 might have potential value for predicting poor prognosis in glioma patients.

  4. These findings provide the first mechanistic link between TRIM8 and the drug resistance of clear cell Renal Cell Carcinoma (show MOK Proteins)

  5. Nucleo-cytoplasmic trafficking of TRIM8, a novel oncogene (show RAB1A Proteins), is involved in positive regulation of TNF (show TNF Proteins) induced NF-kappaB (show NFKB1 Proteins) pathway.

  6. TRIM8 is a p53 (show TP53 Proteins) direct target gene that induces p53 (show TP53 Proteins) stabilization and promotes the degradation of MDM2 (show MDM2 Proteins) protein.

  7. Tripartite motif 8 (TRIM8) modulates TNFalpha (show TNF Proteins)- and IL-1beta (show IL1B Proteins)-triggered NF-kappaB (show NFKB1 Proteins) activation by targeting TAK1 (show MAP3K7 Proteins) for K63-linked polyubiquitination.

  8. TRIM8 modulates translocation of phosphorylated STAT3 into the nucleus through interaction with Hsp90beta and consequently regulates transcription of Nanog in embryonic stem cells.

  9. These findings indicate that TRIM8 enhances the STAT3 (show STAT3 Proteins)-dependent signal pathway by inhibiting the function of PIAS3 (show PIAS3 Proteins).

  10. interacts with SOCS-1 (show SOCS1 Proteins)

Mouse (Murine) Tripartite Motif Containing 8 (TRIM8) interaction partners

  1. these studies reveal an additional regulatory function of TRIM8 in innate immune responses: TRIM8 catalyzes polyubiquitination of TRIF (show RNF138 Proteins), resulting in disruption of TRIF (show RNF138 Proteins)-TBK1 (show TBK1 Proteins) interaction

  2. TRIM8 plays a deleterious role in pressure overload-induced cardiac hypertrophy by accelerating the activation of TAK1 (show NR2C2 Proteins)-dependent signaling pathways.

  3. potent regulator that exacerbates steatohepatitis and metabolic disorders dependent on its binding and ubiquitinating capacity on transforming growth factor-beta-activated kinase 1 (show MAP3K7 Proteins)

  4. TRIM8 has pro-inflammatory effect on Pseudomonas aeruginosa -induced keratitis

  5. Gerp transcribes interferon-gamma (show IFNG Proteins) in epithelial and lymphoid cells and is expressed almost ubiquitously in tissues.

TRIM8 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to nuclear bodies. Its structure is similar to some tumor suppressor proteins and its gene maps to a locus thought to contain tumor suppressor genes.

Gene names and symbols associated with TRIM8

  • tripartite motif containing 8 (TRIM8)
  • tripartite motif containing 8 (trim8)
  • tripartite motif-containing 8 (Trim8)
  • tripartite motif-containing 8 (trim8)
  • AA408830 protein
  • BB006755 protein
  • GERP protein
  • Rnf27 protein
  • si:ch211-208d15.5 protein
  • wu:fc90g07 protein

Protein level used designations for TRIM8

glioblastoma expressed ring finger protein , glioblastoma-expressed RING finger protein , probable E3 ubiquitin-protein ligase TRIM8 , ring finger protein 27 , tripartite motif protein TRIM8 , tripartite motif-containing 8 , tripartite motif-containing protein 8 , tripartite motif protein 8

81603 Homo sapiens
423864 Gallus gallus
486863 Canis lupus familiaris
782444 Bos taurus
100127258 Xenopus laevis
93679 Mus musculus
688785 Rattus norvegicus
559967 Danio rerio
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