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Trophoblast Glycoprotein Proteins (TPBG)

TPBG encodes a leucine-rich transmembrane glycoprotein that may be involved in cell adhesion. Additionally we are shipping TPBG Antibodies (35) and TPBG Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TPBG 7162 Q13641
TPBG 21983 Q9Z0L0
TPBG 83684 Q5PQV5
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Top TPBG Proteins at antibodies-online.com

Showing 10 out of 11 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$809.60
Details
HOST_Escherichia coli (E. coli) Mouse His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$844.80
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Macaca fascicularis His tag   1 mg Log in to see 56 to 66 Days
$2,861.83
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,889.33
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

TPBG Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, , ,
Mouse (Murine) ,
, ,
Rat (Rattus)

More Proteins for Trophoblast Glycoprotein (TPBG) Interaction Partners

Human Trophoblast Glycoprotein (TPBG) interaction partners

  1. In conclusion, the present study provided evidence that TPBG is involved in PDAC metastasis, and that TPBG and its associated signaling pathways may be a suitable target for pancreatic ductal adenocarcinoma therapy.

  2. 5T4 expression is mechanistically associated with the directional movement of cells through epithelial mesenchymal transition, facilitation of CXCL12 (show CXCL12 Proteins)/CXCR4 (show CXCR4 Proteins) chemotaxis, blocking of canonical Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) while favouring non-canonical pathway signalling

  3. Tyrosine 325 plus the leucine-rich repeat 1 surface centered on a second exposed aromatic residue, phenylalanine 97, are essential for inhibition of Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling.

  4. The surface expression of 5T4 marks the use of the CXCR4 (show CXCR4 Proteins) rather than the CXCR7 receptor, with distinct consequences for CXCL12 (show CXCL12 Proteins) exposure.

  5. 5T4 is a potential new antigen for targeted therapies such as immunotherapy in MPM, as it is overexpressed on mesothelioma cells and recognised by 5T4-specific cytotoxic T-cells.

  6. Glycosylation and epitope mapping of the 5T4 glycoprotein oncofoetal antigen

  7. Results sugest that 5T4 is a transient marker of human embryonic stem cell differentiation & that 5T4 phenotype, colony seeding density and culture conditions influence the maintenance of pluripotent hES (show RRBP1 Proteins) cells and their differentiation to neural lineages.

  8. there is a repertoire of CD8 T cell recognition of 5T4 in normal human donors and some candidate HLA-A*0201 epitopes have been identified

  9. the mRNA expression of trophoblast glycoprotein is up-regulated in cells circulating within blood from women with preeclampsia.

  10. 5T4-based cancer vaccine: cytotoxic T lymphocyte epitopes identified in Trovax-vaccinated colorectal cancer patients

Mouse (Murine) Trophoblast Glycoprotein (TPBG) interaction partners

  1. The surface expression of 5T4 marks the use of the CXCR4 (show CXCR4 Proteins) rather than the CXCR7 receptor, with distinct consequences for CXCL12 (show CXCL12 Proteins) exposure.

  2. 5T4 overexpression in newborn olfactory bulb interneurons facilitates their dendritic arborization even under a sensory input-deprived condition.

  3. molecular interaction of 5T4 and CXCR4 (show CXCR4 Proteins) occurring at the cell surface which directly facilitates the biological response to CXCL12 (show CXCL12 Proteins)

  4. Spry4 (show SPRY4 Proteins) and Tpbg/5T4 were detected in Kit-immunoreactive cells only in Kit(K641E), but not in Kit(WT/WT) animals.

  5. Glycosylation and epitope mapping of the 5T4 glycoprotein oncofoetal antigen

  6. 5T4 glycoprotein expression is associated with early differentiative events of embryonic stem cells

  7. A limited expression profile of 5T4 may contribute to the migration of actively cycling, undifferentiated epithelial progenitor cells during embryogenesis

  8. Because 5T4 is known to interact with actin cytoskeleton, these observations suggest that 5T4 is involved in the formation or maintenance of strata-specific dendritic ramification or synaptic connection of subsets of local interneurons.

  9. E-cadherin (show CDH1 Proteins) protein stabilizes cortical actin cytoskeletal arrangement in embryonic stem cells, and this can prevent cell surface localization of the promigratory 5T4 antigen.

TPBG Protein Profile

Protein Summary

This gene encodes a leucine-rich transmembrane glycoprotein that may be involved in cell adhesion. The encoded protein is an oncofetal antigen that is specific to trophoblast cells. In adults this protein is highly expressed in many tumor cells and is associated with poor clinical outcome in numerous cancers. Alternate splicing in the 5' UTR results in multiple transcript variants that encode the same protein.

Gene names and symbols associated with TPBG

  • trophoblast glycoprotein (TPBG)
  • sc:d0347 (sc:d0347)
  • trophoblast glycoprotein (tpbg)
  • Trophoblast glycoprotein (tpbg)
  • trophoblast glycoprotein (Tpbg)
  • 5T4 protein
  • 5T4AG protein
  • AW495680 protein
  • M6P1 protein
  • sc:d0323 protein
  • sc:d0347 protein
  • tpbg protein

Protein level used designations for TPBG

trophoblast glycoprotein , 5T4 oncofetal trophoblast glycoprotein , sc:d0347 , Trophoblast glycoprotein , trophoblast glycoprotein-like , 5T4 oncofetal antigen , 5T4 oncotrophoblast glycoprotein

GENE ID SPECIES
462850 Pan troglodytes
481899 Canis lupus familiaris
540358 Bos taurus
772098 Gallus gallus
792712 Danio rerio
100144407 Danio rerio
100286624 Salmo salar
100379816 Xenopus (Silurana) tropicalis
100405225 Callithrix jacchus
100444954 Pongo abelii
7162 Homo sapiens
21983 Mus musculus
83684 Rattus norvegicus
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